Results 71 to 80 of about 115,664,573 (187)

Inhibition or promotion, the potential role of arginine metabolism in immunotherapy for colorectal cancer

All Life, 2023
Colorectal cancer (CRC) is the third most common cancer in the world, with increasing morbidity and mortality. The current diagnosis and treatment plan rely on early detection and comprehensive treatment based on surgery.
Chengyang Chen, Xia Jiang, Zengren Zhao
doaj   +1 more source

Hepatic Adenomas in Men: Diagnostic Considerations and Management in the Modern Era

Journal of Surgical Oncology, EarlyView.
ABSTRACT Hepatic adenomas (HAs) are rare benign liver tumors traditionally associated with young women, yet contemporary epidemiologic trends reveal increasing recognition among men. Historically, universal resection in males has been recommended because of a nearly tenfold increased risk of malignant transformation as reported by Farges et al.
Teresa Belledent, Julie Nwosu, Kiers Brevik, Raegen M. Abbey, Timothy Pawlik, Dae Sun Hwang, Terry L. Hayes, Ikenna Nwosu, Mohammed O. Suraju, Hassan Aziz   +9 more
wiley   +1 more source

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Modulation of intestinal urea cycle by dietary spermine in suckling rat

, 2005
peer reviewedArgininosuccinate synthetase, an ubiquitous enzyme in mammals, catalyses the formation of argininosuccinate, the precursor of arginine. Arginine is recognised as an essential amino acid in foetuses and neonates, but also as a conditionally ...
Powroznik, Brigitte, Rusu, Dorina, Mazzucchelli, Gabriel, Dandrifosse, Guy, Nollevaux, Géraldine, Gharbi, Myriam, Deville, Christelle, Peulen, Olivier   +7 more
core   +1 more source

Impaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome

Cellular Physiology and Biochemistry, 2017
Background: Though oxidative stress is associated with Polycystic Ovary Syndrome (PCOS), the status of nitric oxide is still unclear. Nitric Oxide (NO) plays pivotal roles in many physiological functions which are compromised in PCOS.
Meera B. Krishna, Annu Joseph, Philip Litto Thomas, Belinda Dsilva, Sathy M. Pillai, Malini Laloraya   +5 more
doaj   +1 more source

Argininosuccinate lyase deficiency causes blood-brain barrier disruption via nitric oxide–mediated dysregulation of claudin expression

JCI Insight, 2023
Nitric oxide (NO) is a critical signaling molecule that has been implicated in the pathogenesis of neurocognitive diseases. Both excessive and insufficient NO production have been linked to pathology.
Jordan Kho, Urszula Polak, Ming-Ming Jiang, John D. Odom, Jill V. Hunter, Saima M. Ali, Lindsay C. Burrage, Sandesh C.S. Nagamani, Robia G. Pautler, Hannah P. Thompson, Akihiko Urayama, Zixue Jin, Brendan Lee   +12 more
doaj   +1 more source

PSMD2 contributes to the progression of esophageal squamous cell carcinoma by repressing autophagy

Cell & Bioscience, 2023
Background The ubiquitin–proteasome and autophagy-lysosomal systems collaborate in regulating the levels of intracellular proteins. Dysregulation of protein homeostasis is a central feature of malignancy.
Yachen Liu, Meng Wu, Shuxiang Xu, Xiangjie Niu, Weiling Liu, Chuanwang Miao, Ai Lin, Yang Xu, Lili Yu   +8 more
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Table_1_Heterologous Expression of Argininosuccinate Synthase From Oenococcus oeni Enhances the Acid Resistance of Lactobacillus plantarum.DOC

, 2019
Oenococcus oeni can survive well in wine (an acid-stress environment) and dominate malolactic fermentation (MLF). To demonstrate a possible role of argininosuccinate synthase gene (argG) in the acid tolerance response of O.
Hua Li (46469), Hongyu Zhao (4728), Shuai Peng (142133), Hua Wang (13530), Lin Yuan (46306), Longxiang Liu (4374475)   +5 more
core   +1 more source

Effects of N‐Acetylcysteine on Oxidative Status and Intestinal Health in Piglets (Sus scrofa domesticus L.): A PRISMA‐Based Systematic Review

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Oxidative stress is a critical challenge in intensive swine production, particularly during weaning, compromising intestinal integrity and animal performance. N‐acetylcysteine (NAC) has emerged as a multifunctional nutritional strategy to mitigate these effects due to its role as a glutathione precursor and signaling modulator. This systematic
Jessica Lucilene Cantarini Buchini, Karoline Silva de Camargo, Lucas Rocha Valfré, Núbia Michelle Vieira da Silva, Rodrigo Garófallo Garcia, Vivian Aparecida Rios e Castilho Heiss, Claudia Marie Komiyama, Fabiana Ribeiro Caldara   +7 more
wiley   +1 more source