Results 51 to 60 of about 115,664,573 (187)

Hepatic urea, creatinine and uric acid metabolism in dairy cows with divergent milk urea concentrations

Scientific Reports, 2022
Milk urea concentration is an indicator for dietary nitrogen (N)-supply and urinary N-excretion. Dairy cows with high (HMU) compared to low milk urea (LMU) concentration have greater plasma urea, creatinine and uric acid concentrations, but if the liver ...
Marie C. Prahl, Carolin B. M. Müller, Dirk Albrecht, Franziska Koch, Klaus Wimmers, Björn Kuhla   +5 more
doaj   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Arginine Signaling and Cancer Metabolism

Cancers, 2021
Simple Summary In this review, we describe arginine’s role as a signaling metabolite, epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent progress in the application of arginine deprivation as a cancer therapy. Abstract
Chia-Lin Chen, Sheng-Chieh Hsu, D. Ann, Yen Yun, H. Kung   +4 more
semanticscholar   +1 more source

The Effect of Atopic Dermatitis and Diet on the Skin Transcriptome in Staffordshire Bull Terriers

Frontiers in Veterinary Science, 2020
Canine atopic dermatitis (CAD) has a hereditary basis that is modified by interactions with the environment, including diet. Differentially expressed genes in non-lesional skin, determined by RNA sequencing before and after a dietary intervention, were ...
Johanna Anturaniemi, Sara Zaldívar-López, Huub F. J. Savelkoul, Kari Elo, Anna Hielm-Björkman   +4 more
doaj   +1 more source

Beyond Protein Synthesis: The Multifunctional Role of Functional Amino Acids in Modulating Meat Quality in Ruminants

Animal Research and One Health, EarlyView.
Multifunctional roles of functional amino acids in regulating meat quality in ruminants: Functional amino acids (FAAs) regulate ruminant meat quality through multiple interconnected mechanisms, including antioxidant protection, metabolic regulation, signal transduction, structural support, and gene expression modulation.
Zixin Liu, Tian Xia, Xiaokang Lv, Man Ren, Chuanshe Zhou, Zhiliang Tan   +5 more
wiley   +1 more source

Species Dynamics and Gene Expression in Algal Polycultures Under Mixotrophic Cultivation in Outdoor Pilot‐Scale Nordic Conditions

Biotechnology and Bioengineering, EarlyView.
These results demonstrate that mixotrophic conditions drive both microbial community shifts and metabolic reprogramming, underscoring the importance of cultivation strategy and polyculture selection for targeted applications such as nutrient recovery and bioproduct generation.
Quyen Nham, Hanna Farnelid, Catherine Legrand, Elin Lindehoff   +3 more
wiley   +1 more source

Analysis of Non-Relapsed and Relapsed Adult Type Granulosa Cell Tumors Suggests Stable Transcriptomes during Tumor Progression

Current Issues in Molecular Biology, 2022
Adult-type granulosa cell tumor (AGCT) is a rare ovarian malignancy characterized by slow growth and hormonal activity. The prognosis of AGCT is generally favorable, but one-third of patients with low-stage disease experience a late relapse, and over ...
Noora Andersson, Ulla-Maija Haltia, Anniina Färkkilä, Swee Chong Wong, Katja Eloranta, David B. Wilson, Leila Unkila-Kallio, Marjut Pihlajoki, Antti Kyrönlahti, Markku Heikinheimo   +9 more
doaj   +1 more source

Primers used for qPCR.

, 2014
CPS1, carbamoyl phosphate synthetase 1; OTC, ornithine carbamoyltransferase; ASS1, argininosuccinate synthetase; ASL, argininosuccinate lyase; ARG1, arginase; NAGS, N-acetylglutamate synthase; GLUL, glutamate–ammonia ligase; GLUD1, glutamate ...
Giora van Straten (580550), Frank C. P. Holstege (117137), Robert P. Favier (144780), Marian J. A. Groot Koerkamp (117136), Frank G. van Steenbeek (194928), Hille Fieten (144796), Ingrid H. van Gils (580551), Guy C. M. Grinwis (165277), Bart Spee (66184), Jan Rothuizen (66188), Anne Kummeling (381713)   +10 more
core   +1 more source

Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and Viability

Frontiers in Oncology, 2019
Interfering with tumor metabolism by specifically restricting the availability of extracellular nutrients is a rapidly emerging field of cancer research. A variety of tumor entities depend on the uptake of the amino acid arginine since they have lost the
Anke Werner, Anke Werner, Daniel Pieh, Hakim Echchannaoui, Johanna Rupp, Krishnaraj Rajalingam, Matthias Theobald, Matthias Theobald, Matthias Theobald, Matthias Theobald, Ellen I. Closs, Markus Munder, Markus Munder   +12 more
doaj   +1 more source

L-Canavanine potentiates the cytotoxicity of doxorubicin and cisplatin in arginine deprived human cancer cells [PDF]

PeerJ, 2016
The non-protein amino acid L-canavanine (L-CAV), an antimetabolite of L-arginine (L-ARG), can alter the 3D conformation of proteins when incorporated into a protein instead of L-ARG. L-CAV inhibits the proliferation of some tumour cells.
Agustina DR Nurcahyanti, Michael Wink
doaj   +2 more sources