Results 31 to 40 of about 115,664,573 (187)

Evaluation of the Neurodevelopmental Status for Urea Cycle Disorders: Based on Clinical Experience

Journal of Pediatric Research, 2023
Aim:Urea cycle disorders (UCD) still have poor neurological outcomes despite early diagnosis and treatment. We aimed to present the neurological outcomes of UCD patients and to determine the main simple and accessible factors affecting these outcomes ...
Ayşe Ergül Bozacı, Emine Göksoy, Aysel Tekmenuray Ünal, Hatice Mutlu Albayrak, İbrahim Taş, Berat Kanar, Mehmet Nuri Özbek, Melis Köse   +7 more
doaj   +1 more source

Dietary N-carbamylglutamate supplementation improves ammonia tolerance of juvenile yellow catfish Pelteobagrus fulvidraco

Frontiers in Physiology, 2023
Introduction: Ammonia has been of concern for its high toxicity to animals. N-carbamylglutamate (NCG) can reduce blood ammonia levels in mammals, but studies on ammonia tolerance in fish are insufficient.Methods: Juvenile yellow catfish were fed two ...
Dexiang Feng, Zhiguo Yang, Ming Li
doaj   +1 more source

Inhibition of argininosuccinate synthase (ASS) affected ammonia excretion in yellow catfish Pelteobagrus fulvidraco during acute ammonia poisoning

Aquaculture Reports, 2022
Ammonia is toxic to most fish. Different fish have different treatment methods for ammonia toxicity, mainly including urea cycle and glutamine synthesis pathway, depending on their physiological status.
Pengwei Song, Ming Li, Muzi Zhang, Haibo Jiang, Jian Shao, Rixin Wang, Yunxia Qian, Dexiang Feng   +7 more
doaj   +1 more source

An Exopolysaccharide from Lactiplantibacillus plantarum ZGS521 Alleviates Colitis via Gut Microbiota Modulation and Enhanced Arginine Biosynthesis.

Journal of Agricultural and Food Chemistry
This work explored the protective effects and mechanisms of exopolysaccharide C-LPE3 from Lactiplantibacillus plantarum ZGS521 against DSS-induced ulcerative colitis (UC).
Wei Xia, Xin-Yue Li, Wei Liu, Kui Wang, Tao Zhou   +4 more
semanticscholar   +2 more sources

Identification of Novel Mutations in Chinese Infants With Citrullinemia

Frontiers in Genetics, 2022
Citrullinemia is a rare autosomal recessive disorder characterized by elevated concentrations of citrulline in the blood resulting from malfunction of the urea cycle. It is categorized into two types, types I and II, which are caused by argininosuccinate
Zhi Cheng, Zhi Cheng, Xiwen He, Fa Zou, Zhen-E Xu, Zhen-E Xu, Chun Li, Chun Li, Hao Liu, Jingkun Miao   +9 more
doaj   +1 more source

Evodiamine Inhibits Colorectal Cancer by Downregulating ASS1 via Wnt/β-Catenin/c-MYC Pathway to Block Arginine Synthesis

Pharmaceuticals
Background: Argininosuccinate synthase 1 (ASS1), a key enzyme in arginine biosynthesis, is highly expressed in colorectal cancer (CRC) and promotes cancer progression, making it a potential therapeutic target.
Huimin Wang, Hao Deng, Jiaming He, Jing Ma, Yunying Li, Haoyue Lv, Jianhua Ran, Dilong Chen, Jing Li   +8 more
doaj   +2 more sources

Expression pattern and biochemical properties of zebrafish N-acetylglutamate synthase. [PDF]

PLoS ONE, 2014
The urea cycle converts ammonia, a waste product of protein catabolism, into urea. Because fish dispose ammonia directly into water, the role of the urea cycle in fish remains unknown.
Ljubica Caldovic, Nantaporn Haskins, Amy Mumo, Himani Majumdar, Mary Pinter, Mendel Tuchman, Alison Krufka   +6 more
doaj   +1 more source

Effects of Thermal Conditioning on Changes in Hepatic and Muscular Tissue Associated With Reduced Heat Production and Body Temperature in Young Chickens

Frontiers in Veterinary Science, 2021
Effects of increased summer temperatures on poultry production are becoming more pronounced due to global warming, so it is important to consider approaches that might reduce heat stress in chickens.
Yoshimitsu Ouchi, Vishwajit S. Chowdhury, John F. Cockrem, Takashi Bungo   +3 more
doaj   +1 more source

LINF_230007900

, 2022
argininosuccinate synthase | Citrulline-aspartate ligaseLeishmania infantum (strain JPCM5)THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Requena, J (via Mendeley Data), Requena, Jose M.   +1 more
core   +1 more source

Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression

Frontiers in Immunology, 2017
In the tumor microenvironment, arginine is metabolized by arginase-expressing myeloid cells. This arginine depletion profoundly inhibits T cell functions and is crucially involved in tumor-induced immunosuppression.
Anke Werner, Anke Werner, Miriam Koschke, Nadine Leuchtner, Claudia Luckner-Minden, Alice Habermeier, Johanna Rupp, Christin Heinrich, Roland Conradi, Ellen I. Closs, Markus Munder, Markus Munder   +11 more
doaj   +1 more source