Results 81 to 90 of about 115,664,573 (187)

The effects of quercetin on the gene expression of arginine metabolism key enzymes in human embryonic kidney 293 cells [PDF]

, 2021
Background: Arginine metabolism is an important factor involved in tumorigenesis, progression, and survival of tumor cells. Besides, other metabolites produced in the arginine metabolism process, such as polyamines, nitric oxide, argininosuccinate, and ...
Farivar, S., Sangtarash, M.H., Amini, R., Jamehdor, S., Pajouhanfar, S., Teimoori, A.   +5 more
core  

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

The Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min, Órlaith C. Henry, Luke A. J. O'Neill   +2 more
wiley   +1 more source

Phase 1 trial of ADI‐PEG 20 and liposomal doxorubicin in patients with metastatic solid tumors

Cancer Medicine, 2022
Background Arginine depletion interferes with pyrimidine metabolism and DNA damage repair pathways. Preclinical data demonstrated that depletion of arginine by PEGylated arginine deiminase (ADI‐PEG 20) enhanced liposomal doxorubicin (PLD) cytotoxicity in
Shuyang Yao, Filip Janku, Kimberly Koenig, Apostolia Maria Tsimberidou, Sarina Anne Piha‐Paul, Nai Shi, John Stewart, Amanda Johnston, John Bomalaski, Funda Meric‐Bernstam, Siqing Fu   +10 more
doaj   +1 more source

Plant NAOGAT (ArgJ) Structure Reveals Mechanism of Ornithine Biosynthesis, Preference for Acetylornithine and Susceptibility to Mangotoxin

Plant, Cell &Environment, Volume 49, Issue 12, Page 10283-10300, December 2026.
ABSTRACT Arginine metabolism in plants is targeted by phytopathogens such as Pseudomonas syringae strains, which produce toxins that affect enzymes of plant arginine metabolism, causing devastating infections in crops. In this work, the structural and functional properties of plant N‐acetylornithine glutamate acetyltransferase (NAOGAT), the key ...
Maciej Nielipinski, Agnieszka J. Pietrzyk‐Brzezinska, Aleksandra Twarda‐Clapa, Bartosz Sekula   +3 more
wiley   +1 more source

Finding My Path: Listening, Learning, and Leading in Rare Disease: The 2025 Hower Award

Annals of the Child Neurology Society, EarlyView.
Andrea Gropman
wiley   +1 more source

Overview on ornithine synthesis and degradation.

, 2019
ADC1/2, arginine decarboxylase 1 and 2; ArgAH, arginine amidohydrolase; ASL, argininosuccinate lyase; ASSY, argininosuccinate synthetase; CARA, carbamoyl phosphate synthetase A; CARB, carbamoyl phosphate synthetase B; NAGS, N-acetyl-L-glutamate synthase;
Miriam Laxa (6236678), Marco Mühlenbruch (6236672), Christoph Peterhänsel (6236675), Christian Blume (6236666), Julia Ost (6236669)   +4 more
core   +1 more source

Endothelial arginine resynthesis contributes to the maintenance of vasomotor function in male diabetic mice. [PDF]

PLoS ONE, 2014
Argininosuccinate synthetase (ASS) is essential for recycling L-citrulline, the by-product of NO synthase (NOS), to the NOS substrate L-arginine. Here, we assessed whether disturbed arginine resynthesis modulates endothelium-dependent vasodilatation in ...
Ramesh Chennupati, Merlijn J P M T Meens, Vincent Marion, Ben J Janssen, Wouter H Lamers, Jo G R De Mey, S Eleonore Köhler   +6 more
doaj   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Molecular docking studies of natural compounds of naringin on enzymes involved in the urea cycle pathway in hyperammonemia [PDF]

, 2020
Purpose: To investigate the anti-hyperammonemic activity of naringin by molecular docking via in silico studies.Methods: Urea cycle proteins were docked to the natural compound naringin as well as a standard drug, sodium benzoate.
Arumugam, Ramakrishnan, Mani, Renuka, Venkatesan, Amalan, Natesan, Vijayakumar, Sengamalai, Senthilmurugan, Kim, Sung-Jin   +5 more
core   +1 more source

Genetic Engineering Efforts to Generate Chlamydomonas Strains for Large‐Scale Biomolecule Production

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
This represents the main aspects relevant to potential industrialization of Chlamydomonas. ABSTRACT Chlamydomonas reinhardtii is an established model microalga. Its easy manipulation, metabolic flexibility and tractable genomes allowed researchers to investigate fundamental processes such as photosynthesis using genetic studies for decades ...
Sofia Inturri, Nicolas Rouhier, Claire Remacle   +2 more
wiley   +1 more source