Results 101 to 110 of about 115,664,573 (187)

Inadvertent gene silencing of argininosuccinate synthase (bcass1) in Botrytis cinerea by the pLOB1 vector system

, 2010
For several years, researchers working on the plant pathogen Botrytis cinerea and a number of other related fungi have routinely used the pLOB1 vector system, based on hygromycin resistance, under the control of the Aspergillus nidulans oliC promoter and
Patel, R.M., Bailey, A.M., Kan, J.A.L., van, Foster, G.D., van Kan, JA, ANDY M. BAILEY, GARY D. FOSTER, Bailey, AM, RISHA M. PATEL, Foster, GD, JAN A. L. VAN KAN, Patel, RM   +11 more
core   +1 more source

Exogenous arginine differentially regulates inflammatory cytokine and inducible nitric oxide synthase expression in macrophages

ImmunoHorizons
Immune dysfunction and late mortality from multiorgan failure are hallmarks of severe sepsis. Arginine, a semi-essential amino acid important for protein synthesis, immune response, and circulatory regulation, is deficient in sepsis.
Kelsey M Stayer, Saliha S. Pathan, Aalekhya Biswas, Huiqiao Li, Yi Zhu, F. Lam, Juan Marini, S. Thevananther   +7 more
semanticscholar   +1 more source

Partial deletion of argininosuccinate synthase protects from pyrazole plus lipopolysaccharide-induced liver injury by decreasing nitrosative stress

, 2012
Argininosuccinate synthase (ASS) is the rate-limiting enzyme in the urea cycle. Along with nitric oxide synthase (NOS)-2, ASS endows cells with the l-citrulline/nitric oxide (NO·) salvage pathway to continually supply l-arginine from l-citrulline for ...
Ward, Stephen C., Natalia Nieto, Leung, Tung Ming, Lu, Yongke, Tung Ming Leung, Stephen C. Ward, Nieto, Natalia, Yongke Lu   +7 more
core   +1 more source

ZFPL1 Promotes Colorectal Cancer Progression by Stabilizing ASS1 to Drive the Urea Cycle and M2 Macrophage‐Mediated Metastatic Colonization

Advanced Science
Colorectal cancer (CRC) progression is driven by diverse molecular mechanisms, underscoring the urgent need for novel therapeutic strategies, especially for liver metastases. Through an integrated analysis of multiple single‐cell RNA sequencing databases,
Xiangjun Qian, Chenxi Xie, Beilin Zhang, Hengsong Cao, Zhengqing Lu, Li Liu, Shipeng Dai, Xiaoqian Wang, Xiaokai Zhang, Feng Han, Yanyan Liu, Haibo Yu, Weiwei Tang, Jinxue Zhou, Xiaopei Hao   +14 more
doaj   +1 more source

Early cirrhosis in a patient with type I citrullinaemia (CTLN1)

, 2004
A 17-month-old girl with type I classical citrullinaemia (CTLN1) presenting with early cirrhosis and unusual ultrastructural features of the liver is reported.
E. Aşan, Tokatli, AYŞEGÜL, P. Atilla, M. Çağlar, Atilla, PERGİN, Caglar, M, Asan, E, Ş. Güçer, Gucer, S, A. Tokatl   +9 more
core   +1 more source

Proposed model showing the urea cycle, nitrate transport and assimilation, and the glutamine-glutamate cycle.

, 2014
Enzymes that are involved in these pathways are labeled with colors that indicate the fold change (log2) in their transcript levels in urea-grown cells relative to nitrate-grown cells (color code is provided in the figure).
Jing-Yi Cen (648108), Kai-Xuan Huang (648105), Yue-Lei Dong (648109), Hua-Long Wang (648106), Song-Hui Lu (648107), Hong-Po Dong (648104)   +5 more
core   +1 more source

Urea cycle.

, 2016
In the urea cycle the “toxin” ammonium (NH4+) is converted to non-toxic urea by five consecutive enzymatic reactions in the liver. In hepatocytes, the rate-limiting, ATP-dependent enzyme carbamoyl phosphate synthetase 1 (CPS1), which is allosterically ...
Matthias Gautschi (2608306), Tamar Stricker (2608312), Adrian Keogh (174242), Johannes Häberle (719209), Renata C. Gallagher (2608315), Alexander Laemmle (174189), Jean-Marc Nuoffer (334268), Matthias R. Baumgartner (2608309)   +7 more
core   +1 more source

Multi-Level Regulation Of Argininosuccinate Synthase: Significance For Endothelial Nitric Oxide Production

, 2008
The citrulline-nitric oxide (NO) cycle, comprised of the enzymes argininosuccinate synthase (AS), argininosuccinate lyase (AL) and endothelial nitric oxide synthase (eNOS), is responsible for the regulated production of endothelial NO.
Corbin, Karen Davidowitz
core  

The two major pathways metabolizing ammonia: the urea cycle (periportal), and glutamine synthesis (pericentral).

, 2014
In the urea cycle: ammonia and bicarbonate form carbamoylphosphate via carbamoyl phosphate synthetase1 (CPS1). This reaction requires N-acetylglutamate (acquired via a reaction catalysed by N-acetylglutamate synthase (NAGS)), Mg2+ and MgATP ...
Giora van Straten (580550), Frank C. P. Holstege (117137), Robert P. Favier (144780), Marian J. A. Groot Koerkamp (117136), Frank G. van Steenbeek (194928), Hille Fieten (144796), Ingrid H. van Gils (580551), Guy C. M. Grinwis (165277), Bart Spee (66184), Jan Rothuizen (66188), Anne Kummeling (381713)   +10 more
core   +1 more source

Transcript levels of genes encoding either urea cycle enzymes or enzymes in linked pathways determined at 400 ppm and 100 ppm CO₂ and standardized to PP2A.

, 2019
Data are the mean of five biological replicates ± SD. Significance was tested according to the two-tailed Student's t-test (* p2 ratios to allow this test.
Miriam Laxa (6236678), Marco Mühlenbruch (6236672), Christoph Peterhänsel (6236675), Christian Blume (6236666), Julia Ost (6236669)   +4 more
core   +1 more source