HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans
eLife, 2021 Eukaryotic cells use guided search to coordinately control dispersed genetic elements. Argonaute proteins and their small RNA cofactors engage nascent RNAs and chromatin-associated proteins to direct transcriptional silencing.
Heesun Kim +6 more
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microRNA-mediated regulation of microRNA machinery controls cell fate decisions
eLife, 2021 microRNAs associate with Argonaute proteins, forming the microRNA-induced silencing complex (miRISC), to repress target gene expression post-transcriptionally.
Qiuying Liu +4 more
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Lost and Found: Piwi and Argonaute Pathways in Flatworms
Frontiers in Cellular and Infection Microbiology, 2021 Platyhelminthes comprise one of the major phyla of invertebrate animals, inhabiting a wide range of ecosystems, and one of the most successful in adapting to parasitic life.
Santiago Fontenla +2 more
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Imaging translational control by Argonaute with single-molecule resolution in live cells
Nature Communications, 2022 Guided by miRNA, Argonaute proteins silence mRNA in multiple ways that are not well understood. Here, the authors develop live-cell biosensors to image the impact tethered regulatory factors, such as Argonaute, have on single-mRNA translation dynamics.
Charlotte A. Cialek +5 more
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Functional Characterization of Entamoeba histolytica Argonaute Proteins Reveals a Repetitive DR-Rich Motif Region That Controls Nuclear Localization [PDF]
MSphere, 2019 Dipak Manna +2 more
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A Prokaryotic Twist on Argonaute Function
Life, 2015 Argonaute proteins can be found in all three domains of life. In eukaryotic organisms, Argonaute is, as the functional core of the RNA-silencing machinery, critically involved in the regulation of gene expression.
Sarah Willkomm +3 more
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DNA recognition by an RNA-guided bacterial Argonaute. [PDF]
PLoS ONE, 2017 Argonaute (Ago) proteins are widespread in prokaryotes and eukaryotes and share a four-domain architecture capable of RNA- or DNA-guided nucleic acid recognition. Previous studies identified a prokaryotic Argonaute protein from the eubacterium Marinitoga
Kevin W Doxzen, Jennifer A Doudna
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In Silico Identification, Phylogenetic and Bioinformatic Analysis of Argonaute Genes in Plants
International Journal of Genomics, 2014 Argonaute protein family is the key players in pathways of gene silencing and small regulatory RNAs in different organisms. Argonaute proteins can bind small noncoding RNAs and control protein synthesis, affect messenger RNA stability, and even ...
Khaled Mirzaei +3 more
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The Varied Roles of Nuclear Argonaute-Small RNA Complexes and Avenues for Therapy
Molecular Therapy: Nucleic Acids, 2014 Argonautes are highly conserved proteins found in almost all eukaryotes and some bacteria and archaea. In humans, there are eight argonaute proteins evenly distributed across two clades, the Ago clade (AGO1-4) and the Piwi clade (PIWIL1-4).
Jason P Ross, Zena Kassir
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Argonaute protein-based nucleic acid detection technology
Frontiers in Microbiology, 2023 It is vital to diagnose pathogens quickly and effectively in the research and treatment of disease. Argonaute (Ago) proteins are recently discovered nucleases with nucleic acid shearing activity that exhibit specific recognition properties beyond CRISPR ...
Zhiyun Wu +3 more
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