Results 161 to 170 of about 19,818 (290)

Engaged Immersive Learning: An Environment-Driven Framework for Higher Education Integrating Multi-Stakeholder Collaboration, Generative AI, and Practice-Based Assessment [PDF]

Journal of Systemics, Cybernetics and Informatics
This paper proposes Engaged Immersive Learning (EIL), a new framework designed to address the passivity, lack of context, and one-way communication that often characterize lecture centered higher education.
Atsushi Yoshikawa
doaj  

Penerapan model pembelajaran argument driven inquiry (ADI) untuk meningkatkan prestasi belajar kognitif siswa SMA materi energi kelas XI [PDF]

Penelitian ini merupakan penerapan model pembelajaran Argument Driven Inquiry untuk meningkatkan Prestasi Belajar kognitif belajar siswa SMA materi Energi kelas XI.
Basri, Fauzan Aninnajib
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Multidisciplinarity is vital to pandemic management and preparedness. [PDF]

Discov Public Health
Pickersgill M.
europepmc   +1 more source

The Influence of the Argument-Driven Inquiry Learning Model in Physics Learning with the STEAM Approach on the Scientific Argumentation Ability

Argument-driven Inquiry (ADI) is a laboratory-based learning model in which students can be involved in argumentation activities to increase understanding and practice argumentation skills.
Epriliyani, Ekaningtyas Wahyu, Deta, Utama Alan   +1 more
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

What AI Cannot Teach: An Epistemological Reconceptualisation of the Nurse Educator Role Based on an Analysis of Carper's Ways of Knowing. [PDF]

Nurs Inq
Sezer E.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Cure as medicine's constitutive aim: a defence of the refined curative thesis. [PDF]

Med Health Care Philos
Ncube L.
europepmc   +1 more source