Results 141 to 150 of about 19,818 (290)

Penerapan model pembelajaran argument driven inquiry untuk meningkatkan keterampilan berpikir kritis peserta didik pada materi usaha dan energi [PDF]

, 2019
Keterampilan berpikir kritis merupakan salah satu keterampilan yang menjadi tuntutan kurikulum 2013 revisi 2017 yang harus dilatihkan kepada peserta didik.
Nurisyani, Azzalya
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Peningkatan penguasaan konsep siswa melalui pembelajaran argument driven inquiry pada pembelajaran IPA Terpadu di SMP kelas VII

Penguasaan konsep IPA yang masih rendah di sekolah-sekolah merupakan pekerjaan bersama dari praktisi pendidikan IPA. Pembelajaran IPA seharusnya dilakukan berdasarkan hakikat IPA itu sendiri yakni proses penyelidikan terhadap alam sekitar secara ...
Yuli Andriani
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PENERAPAN MODEL PEMBELAJARAN ARGUMENT DRIVEN INQUIRY UNTUK MENINGKATKAN KUALITAS ARGUMENTASI PESERTA DIDIK PADA TOPIK PEMBELAJARAN KOMPONEN EKOSISTEM DAN INTERAKSINYA [PDF]

Kurangnya kualitas argumentasi peserta didik dalam kegiatan pembelajaran sehingga perlu ditingkatkan. Peningkatan kualitas argumentasi dapat dilakukan dengan strategi pembelajaran yang tepat yaitu dengan menggunakan model pembelajaran Argument Driven ...
Muhammad Ridzky Herdiana Pratama,
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THE IMPACT OF ARGUMENT-DRIVEN INQUIRY ON STUDENTS’ CONCEPT MASTERY AND SUSTAINABILITY AWARENESS IN LEARNING GLOBAL WARMING [PDF]

, 2018
The process of learning science in some schools is still in the form of direct transfer from teacher to student. The learning process will be meaningful if the students involved and explore more in building a concept.
Erning Rahmadini Salsabila, -
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Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

MODEL ARGUMENT DRIVEN INQUIRY (ADI) DENGAN MEMANFAATKAN GAMIFIKASI UNTUK MENINGKATKAN PENALARAN ILMIAH SISWA

Penelitian ini bertujuan untuk menerapkan penerapan model Argument Driven Inquiry dengan gamifikasi berbasis website wordwall dalam meningkatkan penalaran ilmiah siswa pada materi fluida statis.
Mulvia, Rahmadhani, Saadah, Fitrotus, Muhajir, Siti Nurdianti   +2 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source