Results 131 to 140 of about 394,345 (286)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Penerapan Model ADI (Argument Driven Inquiry) Berbantuan Multimodal Pada Pembelajaran Menulis Argumentasi

Edusentris, 2021
Penelitian ini dilatarbelakangi oleh maraknya pendapat yang terjadi di masyarakat dan membuat banyaknya pendapat yang menggiring masyarakat untuk berargumen pada berita tersebut. berita yang beredar di masyarakat pun tidak sedikit yang berujung di pengadilan karena terjerat UU ITE sebab diksi yang digunakan dianggap menyinggung seseorang ataupun ...
openaire   +1 more source

Implementation of Argument Driven Inquiry Instructional Model to Improve Cognitive Learning Outcomes

Indonesian Journal of Science and Education
Cognitive learning outcomes are important basic skills that students must master. Science learning must be designed so that it can optimally provide students with the cognitive dimension. The importance of cognitive learning outcomes is in contrast to conditions in the field.
Aza Mazita, null Siswanto Siswanto, null Suwito Singgih, null Nuryunita Dewantari, null Djoko Sri Bimo   +4 more
openaire   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Homiletical Aesthetics: A Paradigmatic Proposal for a Holistic Experience of Preaching

, 2017
The article is a proposal for a paradigmatic change in homiletical pedagogy. In North America today, most homiletical training at the seminary or divinity school is either text-driven or know-how-driven (or, at times, topic-driven). Thus, the homiletical
Yang, Sunggu
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PENGEMBANGAN PHYSICS MAGAZINE BERBASIS ARGUMENT-DRIVEN INQUIRY UNTUK MENINGKATKAN KETERAMPILAN ARGUMENTASI SISWA

Jurnal Inovasi Pendidikan dan Teknologi Informasi (JIPTI)
Keterampilan argumentasi siswa di Indonesia tergolong rendah karena kurangnya forum diskusi yang dapat mendorong siswa untuk mengemukakan pendapatnya, sehingga diperlukan media yang dapat meningkatkan keterampilan argumentasi siswa. Tujuan dari penelitian ini adalah menghasilkan bahan ajar berupa Physics Magazine berbasis Argument-Driven Inquiry untuk ...
Rika Sumita Wimanda Sari, Nur Ahmad, null Rusdianto   +2 more
openaire   +1 more source