Results 121 to 130 of about 19,818 (290)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

PENGARUH MODEL ARGUMENT DRIVEN INQUIRY TERHADAP KEMAMPUAN BERPIKIR TINGKAT TINGGI BERDASARKAN PERBEDAAN GAYA BELAJAR SISWA SMP PADA MATERI SISTEM EKSKRESI

, 2022
This study aims to determine the effect of the Argument Driven Inquiry learning model on higher-order thinking skills based on the learning style of VIII grade junior high school students on the excretory system material.
Juhanda, Aa, Nuranti, Gina, Hidayanti, Nurfitri   +2 more
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Implementation of Argument Driven Inquiry Instructional Model to Improve Cognitive Learning Outcomes

Indonesian Journal of Science and Education
Cognitive learning outcomes are important basic skills that students must master. Science learning must be designed so that it can optimally provide students with the cognitive dimension. The importance of cognitive learning outcomes is in contrast to conditions in the field.
Aza Mazita, null Siswanto Siswanto, null Suwito Singgih, null Nuryunita Dewantari, null Djoko Sri Bimo   +4 more
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

From Engagement to Argument Quality: How PBL Develops Critical Reading in EFL/ESP

Journal of English for Academic and Specific Purposes
Critical reading is increasingly essential in EFL/ESP higher education, yet many students still struggle to evaluate claims, evidence, and reasoning in disciplinary texts.
Luthfi Retriansyah, Munawwir Yusuf, Subagya Subagya   +2 more
doaj   +1 more source

Pengaruh Model Pembelajaran Argument-Driven Inquiry Terhadap Keterampilan Argumentasi Siswa

, 2018
This study aims to determine the significance of the influence of the use of Argument-Driven Inquiry (ADI) learning models, students' academic abilities, and the interaction between learning models and academic abilities towards student argumentation ...
Hasnunidah, Neni, Sikumbang, Darlen, Ningtyas, Ninda   +2 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source