Results 71 to 80 of about 136,763,171 (336)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Emergence of argumentation in elementary science classrooms
Canadian Journal for New Scholars in Education, 2020 Scientific argumentation can emerge naturally and spontaneously where students with diverse backgrounds and knowledge interact in classrooms. As research on argumentation as an emergent phenomenon has been limited in school science education, this paper
Qingna Jin, Mijung Kim
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Relationship Between Critical Thinking and Scientific Argumentation in Science Learning
Jurnal Pendidikan IPA IndonesiaThis study aims to examine the relationship between critical thinking and scientific argumentation in the context of science learning. This research method is a systematic literature review of articles published between 2012 and 2022 and indexed in ...
An Nuril Maulida Fauziah +6 more
doaj +1 more source
When children argue: the discursive construction of evidence use in inquiry science lessons
Investigações em Ensino de Ciências, 2017 The aim of this study is to analyze the discursive construction of practices of evidence use during argumentation in science lessons in a 3rd grade classroom. We selected an event considered a telling case to analyze face-to-face interactions. We adopted
Luiz Gustavo Franco Silveira +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Summary Report of The First International Competition on Computational Models of Argumentation [PDF]
, 2016 Computational models of argumentation are an active research discipline within Artificial Intelligence that has grown since the beginning of the 1990s (Dung 1995).
Vallati, Mauro +5 more
core +2 more sources
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Transparent Rational Decisions by Argumentation [PDF]
, 2013 There is a well-documented indication that several applications would benefit from the transparency afforded by argumentation to support decision-making where standard decision theory is not useful, e.g. in healthcare.
Craven, Robert +5 more
core