Results 51 to 60 of about 2,142 (181)

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source

Identification by HPLC of Undeclared Active Ingredients in Aphrodisiac Teas and Coffees Sold in Kinshasa and Kisangani (DRC)

Orapuh Journal
Introduction This study aims to identify the presence of undeclared active ingredients in aphrodisiac products sold as teas and coffees in Kinshasa and Kisangani (DRC). Sexual dysfunction is widespread, and many individuals in the Democratic Republic
Tresor ADONIO, S. Kalonda, R. D. Marini, K. J.  Mbinze   +3 more
doaj   +1 more source

Affinity‐Based Protein Profiling Revealed that HIGD1A is a Direct Target Protein of Aristolochic Acids

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Using an affinity‐based probe, this study reveals that aristolochic acid directly binds to HIGD1A with high affinity in the kidney. This binding disrupts the HIGD1A‐TFAM interaction, which in turn triggers TFAM degradation, cytosolic mitochondrial DNA release, and the activation of inflammatory pathways. Abstract Exposure to aristolochic acids (AA) via
Yin Gong, Shanshan Zhang, Anying Wei, Xiang Ji, Xiaodan Chong, Jinfeng Cen, Xuan Zhao, Zimeng Luo, Zhipeng Pei, Guanchao Mao, Xinkang Zhang, Mingxue Sun, Zhiguo Sun, Zifei Yin, Zhengrong Zou, Wen‐Qi Meng   +15 more
wiley   +1 more source

Arid1a Deficiency Drives Aristolochic Acid‐Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair

Advanced Science, Volume 13, Issue 3, 14 January 2026.
ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang, Shi‐Hao Bai, Shu‐Jin Song, Xiao‐Li Zhang, Xue‐Ying Shang, Zhao‐Ning Lu, Xiao‐Fang Cui, Xin‐Le Zhu, Ze‐Guang Han   +8 more
wiley   +1 more source

Approach to the Interaction Studies of Aristolochia maxima and the Caterpillars of Butterflies Battus polydamas polydamas and Parides panares erythrus

Acta Biológica Colombiana, 2007
Most butterflies of the tribe Troidini (Lepidoptera: Papilionidae) sequester aristolochic acids (AA) for their protection. These acids are derived from their host plants -family Aristolochiaceae- upon which they feed on during their larval stages.
Ricardo A. Claro, Hebelin Correa, Carmenza Duque, Natalia Ruiz   +3 more
doaj  

Identification of a Reduction Product of Aristolochic Acid: Implications for the Metabolic Activation of Carcinogenic Aristolochic Acid [PDF]

Journal of Natural Products, 2010
Aristolochic acids are nephrotoxic and carcinogenic natural products that have been implicated both in endemic nephropathy in the Balkan region and in ailments caused by ingestion of herbal remedies. Aristolochic acids are metabolized to active intermediates that bind to DNA.
Horacio A, Priestap, Carlos, de los Santos, J Martin E, Quirke   +2 more
openaire   +2 more sources

Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice [PDF]

, 2023
Yaping Dong, Shuzhen Chen, Huisi He, Zhuoran Sun, Li-xuan Jiang, Yanqiu Gu, Ying Zhang, Fei Feng, Chun Chen, Zhecai Fan, Xiaofei Chen, Wen Wen, Hongyang Wang   +12 more
openalex   +1 more source

MicroRNA‐382 Is Involved in Acute Kidney Injury via Regulating STAT1 Signaling

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Acute kidney injury (AKI), characterized by inflammation and oxidative stress, is a life‐threatening clinical presentation. We previously demonstrated the role of miR‐382 in the progression of chronic kidney disease (CKD). However, the role of miR‐382 in AKI is unknown.
Xiaoyan Wang, Guo Cheng, Ting Ren, Zhouping Zou, Xinni Zhang, Shuan Zhao, Siyu Bao, Yingxiang Li, Ping Jia, Yi Fang, Xiaoqiang Ding, Poorani Gurumallesh   +11 more
wiley   +1 more source

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source