Results 121 to 130 of about 9,699 (146)

[Aromatase deficiency].

Nihon rinsho. Japanese journal of clinical medicine, 2004
Aromatase, a key enzyme in estrogen synthesis, is tissue-specifically regulated in various tissues and plays an important role through endocrine and intracrine estrogen production in various physiological functions. Therefore, aromatase deficiency caused crucial impairments of physiological functions in the gonadal tissues as well as extra-gonadal ...
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RETRACTED: Neurological effects of aromatase deficiency in the mouse

The Journal of Steroid Biochemistry and Molecular Biology, 2003
In the brain, the conversion from androgen into estrogen is an important process for the differentiation of the brain function in male rodents. The aromatase is expressed in some nucleus of the brain. To assess the functional significance of the aromatase gene in development and activation of sex-specific behavior, we analyzed behavioral phenotypes of ...
Takahiro Matsumoto, Shin-ichiro Honda, Nobuhiro Harada   +2 more
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Aromatase-deficient (ArKO) mice accumulate excess adipose tissue

The Journal of Steroid Biochemistry and Molecular Biology, 2001
Aromatase is the enzyme which catalyses the conversion of C19 steroids into C18 estrogens. We have generated a mouse model wherein the Cyp19 gene, which encodes aromatase, has been disrupted, and hence, the aromatase knockout (ArKO) mouse cannot synthesise endogenous estrogens.
M E, Jones, A W, Thorburn, K L, Britt, K N, Hewitt, M L, Misso, N G, Wreford, J, Proietto, O K, Oz, B J, Leury, K M, Robertson, S, Yao, E R, Simpson   +11 more
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Neurological effects of aromatase deficiency in the mouse.

The Journal of steroid biochemistry and molecular biology, 2004
In the brain, the conversion from androgen into estrogen is an important process for the differentiation of the brain function in male rodents. The aromatase is expressed in some nucleus of the brain. To assess the functional significance of the aromatase gene in development and activation of sex-specific behavior, we analyzed behavioral phenotypes of ...
Takahiro, Matsumoto, Shin-ichiro, Honda, Nobuhiro, Harada   +2 more
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[Estrogen resistance and aromatase deficiency in humans].

Journal de la Societe de biologie, 2003
The primordial role of estrogens in female reproductive function is well known. The recent production of transgenic mice deficient in estrogen receptors (ERKO) or in aromatase (ArKO) and the discovery in man of inactivating mutations of the corresponding genes (ER) have contributed to the understanding of the role of estrogens in metabolic processes in
Cesare, Carani, Matteo, Fabbi, Lucia, Zirilli, Ilaria, Sgarbi   +3 more
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Sexuality in a man with aromatase deficiency

1998
The evaluation of sexual behavior in a man with aromatase deficiency explains the role of estrogen on male sexuality.
CARANI, Cesare, Antonio Balestrieri, Antonio R. M. Granata, Monica Bevini, ROCHIRA, Vincenzo   +4 more
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Human Models of aromatase deficiency

2006
The phenotypes of aromatase deficiency suggest the physiological role of estrogens on the skeleton, on pituitary function, on the reproductive system and on glucose ...
CARANI, Cesare, ZIRILLI, Lucia, ROCHIRA, Vincenzo   +2 more
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Aromatase Deficiency and Estrogen Resistance: From Molecular Genetics to Clinic

Seminars in Reproductive Medicine, 2000
Our knowledge of the physiologic roles of estrogen in women and men has been advanced by recent descriptions of mutations disrupting estrogen biosynthesis and action. Aromatase deficiency results from autosomal recessive inheritance of mutations in the CYP19 gene. It gives rise to ambiguous genitalia in 46,XX individuals.
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Estrogen resistance and aromatase deficiency

1999
The chapter deals with the aspects of estrogen resistance and aromatase deficiency. In particular the role of serum estrogens in the control of gonadotropin feedback is reviewed.
SIMONI, Manuela, ROCHIRA, Vincenzo, Marco Faustini Fustini, CARANI, Cesare   +3 more
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Aromatase Deficiency

2023
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