Results 141 to 150 of about 438,768 (166)

Boosting Male Fertility: The Impact of Gonadotropin Therapy on Hypogonadotropic Hypogonadism—A Systematic Review and Meta‐Analysis

Andrology, Volume 14, Issue 7, Page 1971-1987, October 2026.
ABSTRACT Background Male hypogonadotropic hypogonadism typically presents with azoospermia and is one of the few causes of infertility amenable to a medical intervention. Gonadotropin therapy offers a chance to restore spermatogenesis and fertility in these individuals.
Manou Huijben, Anne Prinsen, Laetitia de Kort, Jetske van Breda   +3 more
wiley   +1 more source

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines

Andrology, Volume 14, Issue 7, Page 1906-1928, October 2026.
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede, George Kanakis, Ewa Rajpert‐De Meyts, Davor Jezek, Ferran Algaba, Gert Dohle, Jolanta Slowikowska‐Hilczer, Sabine Kliesch, Hermann M. Behre, Csilla Krausz, Dimitrios G. Goulis, Niels Jørgensen   +11 more
wiley   +1 more source

Divergent effects of hyperandrogenemia on the female reproductive neuroendocrine axis under different physiological conditions

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract The hypothalamic–pituitary–gonadal (HPG) axis coordinates reproductive function and incorporates gonadal sex steroid feedback to regulate gonadotropin secretion in a homeostatic manner. In females, ovarian estrogens and progestins act as the primary negative feedback signals to suppress luteinizing hormone (LH) release, whereas in males ...
Lillian Rose, Alexander S. Kauffman
wiley   +1 more source

Long‐term endurance running training and testosterone daily variation in ageing men; a comparative cross‐sectional study

Experimental Physiology, Volume 111, Issue 10, Page 4620-4635, 1 October 2026.
Abstract The aim of this study was to assess the relationship between long‐term endurance running training and daily variation in testosterone, which is known to diminish during ageing, in a comparative, cross‐sectional study. We recruited 45 male participants into four groups [young athletes (YA), young sedentary (YS), master athletes (MA) and elderly
Barbora Bartko, Ľudmila Oreská, Gabriel Buzgó, Genc Berisha, Valentína Zemaníková, Monika Okuliarová, Michal Zeman, Milan Sedliak   +7 more
wiley   +1 more source

(S)‐Pyrrolo[1,2‐a]pyrazine‐3‐carboxamide Analogs as Dual Akt/JNK Modulators With Antiproliferative Effects in MDA‐MB‐468 Cells

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Among 30 synthesized pyrrolo[1,2‐a]pyrazine analogs, compounds B1 and B3 showed strong and selective cytotoxicity toward TNBC cells, inducing apoptosis through Akt suppression and JNK activation. Triple‐negative breast cancer (TNBC) remains a major clinical challenge due to the absence of effective targeted therapies.
Narges Hosseininasab, Sou Hyun Kim, Ye‐Mi Kwon, Jungjin Park, Chanhyun Jung, Kwanghee Lee, Beom‐Jun Wi, Su‐Jin Yoo, Soonsil Hyun, Young‐Suk Jung, Jae‐Hwan Kwak   +10 more
wiley   +1 more source

P367: Novel CYP19A1 variant in a male with overgrowth, unilateral foot drop, and nephrolithiasis: Expansion of clinical features in aromatase deficiency

Genetics in Medicine Open
Adnan Alsadah
doaj   +1 more source

Aromatase deficiency in men: a clinical perspective

Nature Reviews Endocrinology, 2009
Human aromatase deficiency is a very rare syndrome characterized by congenital estrogen deprivation that is caused by loss-of-function mutations in CYP19A1, which encodes aromatase.
Vincenzo Rochira, Cesare Carani
exaly   +2 more sources

Tall Stature without Growth Hormone: Four Male Patients with Aromatase Deficiency

Journal of Clinical Endocrinology and Metabolism, 2010
CONTEXT: From preliminary observations, GH-IGF-I seems to be compromised in men with aromatase deficiency. The GH deficiency (GHD) coexists paradoxically with tall stature, raising the question whether or not a true GHD is part of this rare syndrome ...
Vincenzo Rochira, Ezio Ghigo, Gianluca Aimaretti   +2 more
exaly   +2 more sources

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Aromatase deficiency in an Ontario Old Order Mennonite family

Journal of Pediatric Endocrinology and Metabolism, 2021
Maha Saleh, Kevin Coughlin, Samantha Colaiacovo   +2 more
exaly  

Aromatase deficiency: A case series of 46, XX Chinese children and a systematic review of the literature

Clinical Endocrinology, 2020
Lele Li, Chun Gong, Lijun Fan
exaly