Results 131 to 140 of about 438,768 (166)
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu +12 more
wiley +1 more source
On the importance of including both sexes in animal studies – insights from home‐cage monitoring
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater +12 more
wiley +1 more source
Description of the fourth case of an adult man with aromatase deficiency, in particulare the effect of different treatment strategies on bone ...
Gloria Tubert +4 more
core
ABSTRACT Purpose The optimal chemotherapy strategy after progression on cyclin‐dependent kinase 4/6 inhibitors (CDK4/6i) in hormone receptor‐positive/human epidermal growth factor receptor 2‐negative (HR+/HER2−) metastatic breast cancer remains a matter of controversy.
Lara Laini +11 more
wiley +1 more source
Associations of adiposity and total body water with vasomotor symptoms varied according to menopausal stage. Divergent relationships observed across body composition measures suggest that distinct physiological mechanisms may underlie vasomotor symptoms during the menopausal transition and postmenopause.
Katarzyna Górecka, Monika Krzyżanowska
wiley +1 more source
Computational drug discovery integrates molecular docking, molecular dynamics simulations, and translational clinical targeting to identify next‐generation therapeutics that overcome endocrine resistance in ER‐positive breast cancer. Combined with multi‐omics, artificial intelligence, and biomarker‐guided precision oncology, these approaches accelerate
Emmanuel Ifeanyi Obeagu, Yaregal Asres
wiley +1 more source
Abstract Objective To compare the efficacy of the levonorgestrel‐releasing intrauterine system combined with metformin versus oral progestin combined with metformin in fertility‐preserving treatment for patients with atypical endometrial hyperplasia and early endometrial cancer, and to analyze related factors affecting efficacy.
Pengpeng Gu +5 more
wiley +1 more source
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto +8 more
wiley +1 more source
Sexual behavior in a man with aromatase deficiency: role of estrogen on male sexuality
The evaluation of sexual behavior in a man with aromatase deficiency explains the role of estrogen on male sexuality.
Cecilia Garau +7 more
core
ABSTRACT The prostate gland is the only internal organ that continues to enlarge throughout adulthood, and it is an important parameter in the evaluation of benign prostatic enlargement and other prostate disorders. However, data on prostate volume and its associated factors are limited in Ethiopia.
Alemker Molla Yitayew +3 more
wiley +1 more source

