Aromatase inhibitors in men: effects and therapeutic options [PDF]
Reproductive Biology and Endocrinology, 2011 Aromatase inhibitors effectively delay epiphysial maturation in boys and improve testosterone levels in adult men Therefore, aromatase inhibitors may be used to increase adult height in boys with gonadotropin-independent precocious puberty, idiopathic ...
de Jong Frank H, de Ronde Willem
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Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials [PDF]
, 2015 BACKGROUND: The optimal ways of using aromatase inhibitors or tamoxifen as endocrine treatment for early breast cancer remains uncertain.METHODS: We undertook meta-analyses of individual data on 31 920 postmenopausal women with oestrogen-receptor ...
core +6 more sources
A radiation recall phenomenon induced by aromatase inhibitors
Current Problems in Cancer: Case Reports, 2021 Radiation recall phenomena induced by aromatase inhibitors have been poorly reported to the literature.We hereby report the case of an 85-year-old woman who presented a cutaneous recall reaction to letrozole (Femara©), one month after the end of ...
Sabrine Slimani +5 more
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The Role of Phorbol Diesters in Mediating Human Placental Aromatase Cytochrome P450 Activity
Applied Biosciences, 2022 Due to the aromatase enzyme’s involvement in estrogen biosynthesis, aromatase inhibitors have emerged as the preferred treatment for postmenopausal women with ER+ breast cancer.
Chiemela S. Odoemelam +6 more
doaj +1 more source
Preparation of a novel antiserum to aromatase with high affinity and specificity: Its clinicopathological significance on breast cancer tissue. [PDF]
PLoS ONE, 2017 Aromatase inhibitors have been widely used for the endocrine treatment of estrogen-dependent breast cancer in postmenopausal patients. However, clinicopathological studies of aromatase have been limited due to unsatisfactory specificity and/or restricted
Naoki Kanomata +6 more
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Virtual Screening for Identification of Dual Inhibitors against CDK4/6 and Aromatase Enzyme
Molecules, 2023 CDK4/6 and aromatase are prominent targets for breast cancer drug discovery and are involved in abnormal cell proliferation and growth. Although aromatase inhibitors have proven to be effective (for example exemestane, anastrozole, letrozole), resistance
Tenzin Adon +6 more
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The Aromatase–Estrogen System in the Testes of Non-Mammalian Vertebrates
Animals, 2021 Estrogens are important physiological regulators of testicular activity in vertebrates. Estrogen levels depend on the activity of P450 aromatase, the enzyme responsible for the irreversible conversion of testosterone into 17β-estradiol.
Luigi Rosati +4 more
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The effect of third-generation aromatase inhibitors on aromatase avtivity in visceral adipose tissue
Regulatory Mechanisms in Biosystems, 2018 Pathogenesis and clinical manifestations of metabolic syndrome (and other conditions characterized by the growth of fat mass and decreased adiponectin content) is associated with an imbalance of sex hormones, which develops under the influence of ...
D. V. Lytkin +2 more
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Treatment of endometriosis by aromatase inhibitors: efficacy and side effects [PDF]
, 2010 The recent demonstration that aromatase is expressed at higher levels in endometriosis implants than in normal endometrium has led to pilot studies using inhibitor aromatasis in patients with endometriosis.
A.C. Racine +6 more
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Current medical treatment of estrogen receptor-positive breast cancer [PDF]
, 2015 Approximately 80% of breast cancers (BC) are estrogen receptor (ER)-positive and thus endocrine therapy (ET) should be considered complementary to surgery in the majority of patients.
Basso, S. M. M. +2 more
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