Results 131 to 140 of about 597,754 (265)

2,3,5,6-Tetrafluoro-[N-(3-aminopropyl)-ε-caprolactam]-4-pyridine

Molbank
The title compound was synthesized at a near-quantitative yield using the nucleophilic aromatic substitution of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) with perfluoropyridine (PFP). The purity and structure were determined by NMR (1H, 13C, 19F), GC-EIMS,
Chadron M. Friesen, Nathan J. Weeks, Scott T. Iacono   +2 more
doaj   +1 more source

Predicting Regioselectivity in Nucleophilic Aromatic Substitution

, 2016
We have investigated practical and computationally efficient methods for the quantitative prediction of regioisomer distribution in kinetically controlled nucleophilic aromatic substitution reactions.
Simone Tomasi (139458), Björn Herschend (2095801), Mats Svensson (1822822), Magnus Liljenberg (2095804), Tore Brinck (1417816), Tobias Rein (1353243)   +5 more
core   +1 more source

Nitro Reduction‐Based RNA Control and Ultrafast Release

Angewandte Chemie, EarlyView.
A chemical RNA caging–uncaging strategy based on nitro reduction is described. Nitroaryl groups introduced via acylation temporarily block the functions of diverse RNAs in vitro and in living cells. Treatment with a diboronic acid–bipyridine mixture rapidly reduces the nitro groups, releasing RNAs and restoring their activity.
Yiran Zhao, Senfeng Zhang, Junsong Guo, Tuan‐Khoa Kha, Song Chen, Chunyi Hu, Ru‐Yi Zhu   +6 more
wiley   +2 more sources

Ruthenium‐Catalyzed Nitrile‐Acrylate Reductive Coupling by 2‐Propanol: Synthesis of Enantioenriched β‐Amino Esters

Angewandte Chemie, EarlyView.
The first nitrile reductive couplings beyond stoichiometric metals or metalloids are described. Using a ruthenium catalyst derived from RuHCl(CO)(PPh3)3 and Cy‐BIPHEP, 2‐propanol‐mediated reductive coupling of phenyl acrylate with aromatic or aliphatic nitriles delivers α,β‐unsaturated β‐amino esters.
Sebastian Höthker, Colin E. Hayter, Weijia Shen, Michael J. Krische   +3 more
wiley   +2 more sources

A new platform for the synthesis of diketopyrrolopyrrole derivatives via nucleophilic aromatic substitution reactions

Beilstein Journal of Organic Chemistry
Diketopyrrolopyrroles (DPPs) are a versatile group of dyes and pigments with valuable optoelectronic properties. In this work we report the synthesis of highly fluorescent DPP derivatives through straightforward nucleophilic aromatic substitution ...
Vitor A. S. Almodovar, Augusto C. Tomé
doaj   +1 more source

High-Yield Synthesis of N⁴-(3-Chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)quinazoline-4,6-diamine via N-(3-Chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)-6-nitroquinazolin-4-amine

Molbank
The target compound, N4-(3-chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)quinazoline-4,6-diamine, was synthesized in two steps from N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine by a nucleophilic aromatic substitution, yielding N-(3 ...
Susila Thapa, Jeanne L. Bolliger
doaj   +1 more source

Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

, 2013
A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is ...
Anders Foller Larsen, Ritzén, Andreas, Trine P. Petersen, Larsen, Anders Foller, Trond Ulven, Petersen, Trine P, Andreas Ritzén, Ulven, Trond   +7 more
core   +1 more source

A Blue Emissive Heavy Atom‐Free Multiresonant Thermally Activated Delayed Fluorescent Emitter Shows Ultra‐Fast Reverse Intersystem Crossing

Angewandte Chemie, EarlyView.
The extended π‐system and low‐lying n‐π∗ transition endow DDOBDiKTa with a synergistic combination of strong spin‐orbit coupling, small reorganization energy and small ΔEST, enabling this blue boron‐nitrogen‐carbonyl hybrid emitter to achieve a fast kRISC of 6.34 × 106 s−1 together with OLEDs showing small efficiency roll‐off, with EQEmax/EQE10000 of ...
Wenrui Wang, Hassan Hafeez, Sen Wu, Aidan P. McKay, David B. Cordes, Ifor D. W. Samuel, Eli Zysman‐Colman   +6 more
wiley   +2 more sources

Direct synthesis of covalent triazine-based frameworks (CTFs) through aromatic nucleophilic substitution reactions. [PDF]

RSC Adv, 2019
Chen T, Li WQ, Hu WB, Hu WJ, Liu YA, Yang H, Wen K.   +6 more
europepmc   +1 more source

Ruthenium-mediated nucleophilic aromatic substitution of hydrogen in benzene

The direct functionalization of unactivated hydrocarbons remains a significant challenge in modern chemistry. In this study, we demonstrate that a simple ruthenium complex featuring a chelating tBuPN ligand can mediate the nucleophilic aromatic ...
Sub Structural Biochemistry, Broere, Daniël L J, Organic Chemistry and Catalysis, Park, Bohyun, Baik, Mu-Hyun, Gabbert, Philip, Hwang, Donghun, Sub Organic Chemistry and Catalysis, Lutz, Martin, Structural Biochemistry, Melnikov, Stanislav   +10 more
core   +2 more sources