Results 111 to 120 of about 597,754 (265)
Angewandte Chemie, EarlyView.The use of 1,1,3,3‐tetramethyldisiloxane (TMDSO) and potassium tert‐butoxide enables direct alkylation of weakly acidic carbon–hydrogen bonds with alkyl halides. Experimental and computational studies support the formation of a substrate‐associated hydride‐like base, providing a single‐step alternative to the classical deprotonation and electrophile ...
Piers St. Onge +4 more
wiley +2 more sources
Beilstein Journal of Organic Chemistry, 2013 A computational approach using density functional theory to compute the energies of the possible σ-complex reaction intermediates, the “σ-complex approach”, has been shown to be very useful in predicting regioselectivity, in electrophilic as well as ...
Magnus Liljenberg +3 more
doaj +1 more source
Angewandte Chemie, EarlyView.A photocontrolled RAFT strategy enables the alternating copolymerization of 1,3‐disubstituted bicyclo[1.1.0]butanes with electron‐deficient comonomers, affording well‐defined copolymers bearing strained cyclobutane backbones. A high degree of alternation, tunable molecular weights, and excellent end‐group fidelity are achieved through a CTA‐mediated ...
Xia Hu +4 more
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Unusual nucleophilic versus electrophilic aromatic substitution on nitroanilines
, 2000 The reaction of the regioisomeric nitroanilines with KI and HNOs/bentonite system using microwave energy in solvent-free conditions is reported. In accordance with the obtained results, an unusual competence between nucleophilic aromatic substitution ...
Aguilar-Pacheco, R +5 more
core
Angewandte Chemie, EarlyView.1,2‐Aryl migration involving in situ‐generated alkyl iodine(III) species proceeds through a previously unrecognized 1,2‐C/I(III) dyotropic rearrangement. Migratory aryl fluorination, acetoxylation, and alkoxylation of 2‐alkyl‐2‐aryl‐3‐iodopropanoates provide α‐heterofunctionalized products, accompanied by aryl migration from the α‐ to the β‐position ...
Chen‐Xu Liu +3 more
wiley +2 more sources
Correction: Rational design of a "dual lock-and-key" supramolecular photosensitizer based on aromatic nucleophilic substitution for specific and enhanced photodynamic therapy. [PDF]
Chem Sci, 2020 Teng KX, Niu LY, Kang YF, Yang QZ.
europepmc +1 more source
Aromatic Cation Activation: Nucleophilic Substitution of Alcohols and Carboxylic Acids
, 2016 A new method for the nucleophilic substitution of alcohols and carboxylic acids using aromatic tropylium cation activation has been developed. This article reports the use of chloro tropylium chloride for the rapid generation of alkyl halides and acyl ...
Alp Bekensir (1831051) +1 more
core +1 more source
Angewandte Chemie, EarlyView.Electrocatalytic polarity inversion of azlactones unlocks their coupling with electron‐rich reaction partners. Triarylamine‐mediated oxidation of the azlactone enolate generates an electrophilic radical intermediate that undergoes selective C4 functionalization with diverse SOMOphiles.
Paula Rodríguez +6 more
wiley +2 more sources
Functionalized N-Aryl-Substituted Cyclens by Nucleophilic Aromatic Substitution
, 2005 The reaction of trifold protected cyclen with fluorinated dinitroarenes yields aryl-substituted or aryl-bridged cyclen derivatives in good yield.
Subat, M. +3 more
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Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie, EarlyView.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
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