Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation. [PDF]
, 2007 For over a decade, phosducin's interaction with the betagamma subunits of the G protein, transducin, has been thought to contribute to light adaptation by dynamically controlling the amount of transducin heterotrimer available for activation by ...
Arshavsky, Vadim Y +6 more
core
Phosphorylation-induced conformation of beta(2)-adrenoceptor related to arrestin recruitment revealed by NMR [PDF]
, 2018 The C-terminal region of G-protein-coupled receptors (GPCRs), stimulated by agonist binding, is phosphorylated by GPCR kinases, and the phosphorylated GPCRs bind to arrestin, leading to the cellular responses.
Imai, Shunsuke +8 more
core +2 more sources
Structural Determinants of Arrestin Functions [PDF]
, 2013 Arrestins are a small protein family with only four members in mammals. Arrestins demonstrate an amazing versatility, interacting with hundreds of different G protein-coupled receptor (GPCR) subtypes, numerous nonreceptor signaling proteins, and components of the internalization machinery, as well as cytoskeletal elements, including regular ...
Vsevolod V, Gurevich +1 more
openaire +2 more sources
Experimental Physiology, EarlyView.Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted +11 more
wiley +1 more source
A Fungal Arrestin Protein Contributes to Cell Cycle Progression and Pathogenesis
mBio, 2019 Arrestins, a structurally specialized and functionally diverse group of proteins, are central regulators of adaptive cellular responses in eukaryotes.
Calla L. Telzrow +4 more
doaj +1 more source
Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors
Medicinal Research Reviews, Volume 46, Issue 2, Page 445-474, March 2026.ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara +3 more
wiley +1 more source
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
Nature Communications, 2017 Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent ...
Chun-Hua Liu +26 more
doaj +1 more source
Functional Role of Arrestin-1 Residues Interacting with Unphosphorylated Rhodopsin Elements [PDF]
, 2023 Sergey A. Vishnivetskiy +4 more
openalex +1 more source
PAR1 Agonists Stimulate APC-Like Endothelial Cytoprotection and Confer Resistance to Thromboinflammatory Injury [PDF]
, 2018 Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C (APC) is protective in several animal models of disease, and APC has been used clinically in severe sepsis and wound healing.
Aisiku, Omozuanvbo +10 more
core +1 more source