Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators [PDF]
, 2016 This Letter was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Scottish Universities Life Sciences Alliance (SULSA) in 2011Peer ...
Abdelrahman, Mostafa Hamed +4 more
core +1 more source
SnapShot: β-Arrestin Functions
Cell, 2020 The arrestins are ubiquitously expressed adaptor proteins that orchestrate transmembrane signaling cascades triggered by the 7-transmembrane G protein-coupled receptors. While originally discovered as proteins that block receptor-G protein coupling, arrestins are now appreciated for their expanding repertoire of dynamic protein interactions and ...
Seungkirl, Ahn +3 more
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X‐Arrestin: a new retinal arrestin mapping to the X chromosome [PDF]
FEBS Letters, 1993 We have been using a differential cDNA cloning approach to isolate human retina‐specific and retina‐enriched genes [1]. A 1,314 bp cDNA was isolated by this approach, representing a highly retina‐specific message encoding a 388 amino acid protein showing 58%, 50%, and 49% homology to bovine β‐arrestin, and bovine and human retinal arrestin (S‐antigen),
Murakami, Akira +4 more
openaire +2 more sources
The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles
Frontiers in Pharmacology, 2021 Apelin and Elabela are endogenous peptide ligands for Apelin receptor (APJ), a widely expressed G protein-coupled receptor. They constitute a spatiotemporal dual ligand system to control APJ signal transduction and function.
Yunlu Jiang +11 more
doaj +1 more source
Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors [PDF]
, 2015 Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence.
A Busquets-Garcia +112 more
core +6 more sources
Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways [PDF]
Developmental Cell, 2009 Arrestins were identified as mediators of G protein-coupled receptor (GPCR) desensitization and endocytosis. However, it is now clear that they scaffold many intracellular signaling networks to modulate the strength and duration of signaling by diverse types of receptors--including those relevant to the Hedgehog, Wnt, Notch, and TGFbeta pathways--and ...
Kovacs, Jeffrey J. +4 more
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Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. [PDF]
, 2001 Using both confocal immunofluorescence microscopy and biochemical approaches, we have examined the role of beta-arrestins in the activation and targeting of extracellular signal-regulated kinase 2 (ERK2) following stimulation of angiotensin II type 1a ...
Choy, EW +6 more
core +2 more sources
The effects of species ortholog and SNP variation on receptors for free fatty acids [PDF]
, 2013 Although it is widely assumed that species orthologs of hormone responsive G protein-coupled receptors will be activated by the same endogenously produced ligand(s), variation in potency, particularly in cases where more than one receptor responds to the
1000 Genomes Project Consortium +72 more
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Phosphorylation of C3a receptor at multiple sites mediates desensitization, β-arrestin-2 recruitment and inhibition of NF-κB activity in mast cells. [PDF]
PLoS ONE, 2012 Phosphorylation of G protein coupled receptors (GPCRs) by G protein coupled receptor kinases (GRKs) and the subsequent recruitment of β-arrestins are important for their desensitization.
Kshitij Gupta +3 more
doaj +1 more source