Results 121 to 130 of about 17,943 (269)
Design and discovery of a high affinity, selective and β-arrestin biased 5-HT7 receptor agonist
, 2021 Edem K. Onyameh +7 more
openalex +2 more sources
Functional Role of Arrestin-1 Residues Interacting with Unphosphorylated Rhodopsin Elements [PDF]
, 2023 Sergey A. Vishnivetskiy +4 more
openalex +1 more source
Arrestins in Host–Pathogen Interactions
, 2013 In the context of host-pathogen interaction, host cell receptors and signaling pathways are essential for both invading pathogens, which exploit them for their own profit, and the defending organism, which activates early mechanism of defense, known as innate immunity, to block the aggression.
Marullo, Stefano, Coureuil, Mathieu
openaire +4 more sources
Novel mechanisms of G-protein-coupled receptors functions: AT1 angiotensin receptor acts as a signaling hub and focal point of receptor cross-talk [PDF]
, 2018 AT1 angiotensin receptor (AT1R), a prototypical G protein-coupled receptor (GPCR), is the main receptor, which mediates the effects of the renin-angiotensin system (RAS).
Balla, András +3 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska +2 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.We investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Ammaji Rajala +3 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji +7 more
wiley +1 more source
Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptors [PDF]
, 2012 Fluorescence correlation spectroscopy (FCS) and photon counting histogram (PCH) analysis are powerful ways to study mobility and stoichiometry of G protein coupled receptor complexes, within microdomains of single living cells.
Briddon, Stephen J. +2 more
core
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Extracellular vesicles (EVs) mediate intercellular and interorgan communication during both physiological and pathological conditions. EVs include exosomes, ectosomes, and apoptotic bodies and contain bioactive molecules. EVs are delivered to proximal cells or can travel in bodily fluids and reach distant organs, where they trigger a response from the ...
Michela Saviana +4 more
wiley +1 more source