Results 141 to 150 of about 9,354 (195)

Modelling G protein-biased agonism using GLP-1 receptor C-terminal mutations. [PDF]

Mol Metab
Tran HD, Zuo Y, Wong C, Pollard A, Bloom S, Jones B.   +5 more
europepmc   +1 more source

Steric control of signaling bias in the immunometabolic receptor GPR84. [PDF]

Nat Commun
Wang P, Zhang X, Guseinov AA, Jenkins L, von Hallerstein C, Colburn JD, Ives R, Luscombe VB, Marsango S, Oktavia L, Raja A, Greaves DR, Biggin PC, Milligan G, Zhang C, Tikhonova IG, Russell AJ.   +16 more
europepmc   +1 more source

Immunomodulatory crosstalk between GPCR and hippo signaling in cancer: implications for tumor immunity and therapeutic targeting. [PDF]

Front Immunol
Ren X, Xie T, Liu L, Jin X, Zhang M.
europepmc   +1 more source

FLIPs: Genetically encoded molecular biosensors for functional imaging of cell signaling by linear dichroism microscopy. [PDF]

Sci Adv
Miclea P, Nagy-Marková V, Van den Eynde R, Vandenberg W, Sakhi A, Bondar A, Myšková J, Dedecker P, Lazar J.   +8 more
europepmc   +1 more source

Core conformation of arrestin coupling to parathyroid hormone type 1 receptor. [PDF]

Nat Commun
Zhai X, Guo J, Shen Q, Chen LN, Wang G, Shen DD, Zhang C, Xu X, Mao C, Zhang Y, Liu Z.   +10 more
europepmc   +1 more source

Ligand-regulated ACKR3 nanoclustering shapes CXCR4 signaling at the plasma membrane

Santander-Acerete N, García-Cuesta EM, Gardeta SR, Villares R, Artinger M, Gerken OJ, Bueno RA, Leurs R, Vischer HF, Cayuela A, Mateos N, Palacios BS, Rodríguez-Frade JM, Legler DF, Mellado M.   +14 more
europepmc   +1 more source

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Arrestins in Bone

2013
Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis.
Brittany N, Bohinc, Diane, Gesty-Palmer
openaire   +2 more sources

Diversity in arrestin function

Cellular and Molecular Life Sciences, 2009
The termination of heptahelical receptor signaling is a multilevel process coordinated, in large part, by members of the arrestin family of proteins. Arrestin binding to agonist-occupied receptors promotes desensitization by interrupting receptor-G protein coupling, while simultaneously recruiting machinery for receptor endocytosis, vesicular ...
Ryan T, Kendall, Louis M, Luttrell
openaire   +2 more sources

Arrestins lie in wait

Science Signaling, 2023
Preassociation of β-arrestins with the plasma membrane facilitates their interactions with GPCRs.
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Phosphorylation-dependent conformational changes of arrestin in the rhodopsin–arrestin complex

Physical Chemistry Chemical Physics, 2020
Conformations of GPCR-bound arrestin depend on the phosphorylation patterns of the GPCR C-loop.
Dali Wang, Xiangdong Liu, Jianqiang Liu, Chen Song   +3 more
openaire   +2 more sources