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Arrestins as rheostats of GPCR signalling
Nature Reviews Molecular Cell Biology, 2018G protein-coupled receptors (GPCRs) have a central role in a myriad of physiological functions and their dysregulation underlies some of the most prevalent human diseases. They control cell behaviour and cell fate by recruiting and activating intracellular molecules such as heterotrimeric G proteins and arrestins, both of which take active roles in ...
J Silvio, Gutkind, Evi, Kostenis
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Arrestin Regulation of Small GTPases
2013The regulation of small GTPases by arrestins is a relatively new way by which arrestin can exert influence over cell signalling cascades, hence, molecular interactions and specific binding partners are still being discovered. A pathway showcasing the regulation of GTPase activity by β-arrestin was first elucidated in 2001.
Ryan T, Cameron, George S, Baillie
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Characterization of arrestin expression and function
2002Publisher Summary Arrestins mediate the desensitization and trafficking of numerous G protein coupled receptors (GPCRs). Agonist-dependent phosphorylation of GPCRs by GPCR kinases (GRKs) promotes high-affinity binding of arrestins that in turn sterically inhibit G protein interaction with the agonist-activated GPCR. There are currently four mammalian
Stuart J, Mundell +2 more
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β-Arrestins as Important Regulators of Glucose and Energy Homeostasis
Annual Review of Physiology, 2022Sai Prasad Pydi +2 more
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Key Metabolic Functions of β-Arrestins: Studies with Novel Mouse Models
Trends in Endocrinology and Metabolism, 2021Sai Prasad Pydi +2 more
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How Arrestins and GRKs Regulate the Function of Long Chain Fatty Acid Receptors
International Journal of Molecular Sciences, 2022Andrew Tobin +2 more
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