Results 241 to 250 of about 17,943 (269)
Apomorphine differentially engages the cAMP and β-arrestin signaling pathways relative to dopamine at human dopamine receptors. [PDF]
J Neural Transm (Vienna)Yegla B +4 more
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Constitutive activity among orphan G protein-coupled receptors: Molecular mechanisms and pharmacological perspectives. [PDF]
Mol PharmacolMurphy RE, Smith HR, Allen JA.
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Designing allosteric modulators to change GPCR G protein subtype selectivity. [PDF]
NatureMoore MN +13 more
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Permanently biased toward arrestins
Science Signaling, 2021The seven-transmembrane receptors D6R and C5aR2 are natural examples of β-arrestin–biased receptors.
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2013
Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis.
Brittany N, Bohinc, Diane, Gesty-Palmer
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Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis.
Brittany N, Bohinc, Diane, Gesty-Palmer
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Phosphorylation-dependent conformational changes of arrestin in the rhodopsin–arrestin complex
Physical Chemistry Chemical Physics, 2020Conformations of GPCR-bound arrestin depend on the phosphorylation patterns of the GPCR C-loop.
Dali Wang +3 more
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Science Signaling, 2023
Preassociation of β-arrestins with the plasma membrane facilitates their interactions with GPCRs.
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Preassociation of β-arrestins with the plasma membrane facilitates their interactions with GPCRs.
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Science, 2004
The G protein-coupled receptors (GPCRs) transduce signals elicited by many different factors, including hormones, neurotransmitters, and cytokines. Negative and positive regulation of signaling for a majority of GPCRs is controlled by receptor association with the cytoplasmic protein arrestin.
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The G protein-coupled receptors (GPCRs) transduce signals elicited by many different factors, including hormones, neurotransmitters, and cytokines. Negative and positive regulation of signaling for a majority of GPCRs is controlled by receptor association with the cytoplasmic protein arrestin.
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Diversity in arrestin function
Cellular and Molecular Life Sciences, 2009The termination of heptahelical receptor signaling is a multilevel process coordinated, in large part, by members of the arrestin family of proteins. Arrestin binding to agonist-occupied receptors promotes desensitization by interrupting receptor-G protein coupling, while simultaneously recruiting machinery for receptor endocytosis, vesicular ...
Ryan T, Kendall, Louis M, Luttrell
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