Results 251 to 260 of about 17,943 (269)

Arrestins in Metabolic Regulation

2013
This review summarizes the regulatory roles of β-arrestins in whole-body energy balance, body weight control, and carbohydrate and lipid homeostasis. Much research has pointed in the direction of the functions of β-arrestins in mediating desensitization and endocytosis of G protein-coupled receptors as well as in activating the receptor/β-arrestin/ERK ...
Jian, Zhao, Gang, Pei
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Arrestins and Protein Ubiquitination

2013
The adaptor proteins, β-arrestins 1 and 2, were originally identified as inhibitors of G protein signaling at the seven-transmembrane receptors (7TMRs, also called G protein-coupled receptors or GPCRs). Subsequent studies have established β-arrestins as critical multifunctional 7TMR adaptors that mediate receptor trafficking and activate G protein ...
Reddy Peera, Kommaddi, Sudha K, Shenoy
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Sulfhydryl Reactivity Demonstrates Different Conformational States for Arrestin, Arrestin Activated by a Synthetic Phosphopeptide, and Constitutively Active Arrestin

Biochemistry, 1999
The sulfhydryl groups of the three cysteines in bovine arrestin react with DTNB very slowly (over a period of several hours). In the presence of the synthetic phosphopeptide comprising the fully phosphorylated carboxyl-terminal 19 amino acids of bovine rhodopsin, the reactivity of one of the sulfhydryls was enhanced while that of another was greatly ...
J H, McDowell, W C, Smith, R L, Miller, M P, Popp, A, Arendt, G, Abdulaeva, P A, Hargrave   +6 more
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Arrestin Regulation of Small GTPases

2013
The regulation of small GTPases by arrestins is a relatively new way by which arrestin can exert influence over cell signalling cascades, hence, molecular interactions and specific binding partners are still being discovered. A pathway showcasing the regulation of GTPase activity by β-arrestin was first elucidated in 2001.
Ryan T, Cameron, George S, Baillie
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Quantifying Biased β-Arrestin Signaling

2013
It is now established that agonists do not uniformly activate pleiotropic signaling mechanisms initiated by receptors but rather can bias signals according to the unique receptor conformations they stabilize. One of the important emerging signaling systems where this can occur is through β-arrestin.
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Arrestins

2022
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Splice Variants of Arrestins

Experimental Eye Research, 1996
K, Palczewski, W C, Smith
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Arrestins

2013
Cornelia Walther, Stephen S.G. Ferguson
openaire   +1 more source

Arrestin Pathways as Drug Targets

2013
Our growing appreciation of the pluridimensionality of G protein-coupled receptor (GPCR) efficacy, coupled with the phenomenon of orthosteric ligand "bias," offers the prospect of drugs that selectively modulate different aspects of GPCR function for therapeutic benefit.
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Arrestins

2006
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