Results 21 to 30 of about 178,362 (241)

Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.

Cancer Cell, 2020
TP53 is the most frequently mutated gene in cancer, yet these mutations remain therapeutically non-actionable. Major challenges in drugging p53 mutations include heterogeneous mechanisms of inactivation and the absence of broadly applicable allosteric ...
Shuo Chen, Jiale Wu, Ying Liang, Yiwen Tang, Huaxin Song, Li-li Wu, Yangfei Xing, Ni Yan, Yuntong Li, Zhengyuan Wang, Shuhua Xiao, Xin Lu, Saisai Chen, Min Lu   +13 more
semanticscholar   +1 more source

Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma [PDF]

, 2014
Background: Arsenic trioxide has been demonstrated as an effective anti-cancer drug against leukemia and solid tumors both in vitro and in vivo. However, recent phase II trials demonstrated that single agent arsenic trioxide was poorly effective against ...
Chen, Xi, Jiang, Hongchi, Li, Yuejin, Liang, Yingjian, Liu, Jiaren, Liu, Lianxin, Lu, Zhaoyang, Meng, Xianzhi, Pan, Shangha, Qi, Shuyi, Song, Xuan, Sun, Boshi, Wang, Jiabei, Xie, Changming, Yin, Dalong, Zheng, Tongsen   +15 more
core   +2 more sources

Realgar transforming solution as a novel arsenic agent with a lower risk of cardiotoxicity

Journal of Pharmacological Sciences, 2019
QTc prolongation has been observed during arsenic trioxide and realgar's clinical use, and become a huge obstacle for the application. Our lab has obtained the soluble arsenic from realgar named realgar transforming solution or RTS.
Yang Hai, Peng Song, Xin Wang, Longhe Zhao, Qinjian Xie, Jianyin Li, Yang Li, Hongyu Li   +7 more
doaj   +1 more source

Salvianolic Acid B Prevents Arsenic Trioxide-Induced Cardiotoxicity In Vivo and Enhances Its Anticancer Activity In Vitro [PDF]

, 2013
Clinical attempts to reduce the cardiotoxicity of arsenic trioxide (ATO) without compromising its anticancer activities remain to be an unresolved issue.
Chen, Rongchang, Dong, Xi, Luo, Yun, Qin, Meng, Sun, Guibo, Sun, Hong, Sun, Xiaobo, Wang, Min, Wu, Ping, Yao, Fan, Zhang, Qiang   +10 more
core   +3 more sources

Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
BACKGROUND AND PURPOSE Tannic acid (TA), a group of polyphenolic compounds, has multiple anticancer, antimutagenic, antioxidant and anti-inflammatory activities.
Weiyue Jin, Yurun Xue, Yucong Xue, Xue Han, Qiongtao Song, Jianping Zhang, Ziliang Li, Jie Cheng, Shengjiang Guan, Shijiang Sun, L. Chu   +10 more
semanticscholar   +1 more source

Inorganic arsenic trioxide induces gap junction loss in association with the downregulation of connexin43 and E-cadherin in rat hepatic “stem-like” cells

Kaohsiung Journal of Medical Sciences, 2014
Chronic exposure to inorganic arsenic trioxide causes tumors of the skin, urinary bladder, lung, and liver. Several cancer initiators and promoters have been shown to alter cell–cell signaling by interference with gap junction intercellular communication
Pi-Jung Hsiao, Jo-Chi Jao, Jin-Lian Tsai, Wen-Tsan Chang, Kuo-Shyang Jeng, Kung-Kai Kuo   +5 more
doaj   +1 more source

Genomic landscapes and clonality of de novo AML [PDF]

, 2013
No abstract ...
Brewin, John, Chevassut, Timothy, Horne, Gillian   +2 more
core   +1 more source

The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel

BMC Medical Genomics, 2010
Background Drinking water contaminated with inorganic arsenic is associated with increased risk for different types of cancer. Paradoxically, arsenic trioxide can also be used to induce remission in patients with acute promyelocytic leukemia (APL) with a
Liu Qian, Zhang Hao, Smeester Lisa, Zou Fei, Kesic Matt, Jaspers Ilona, Pi Jingbo, Fry Rebecca C   +7 more
doaj   +1 more source

Arsenic Trioxide Inhibits Cell Growth and Induces Apoptosis through Inactivation of Notch Signaling Pathway in Breast Cancer [PDF]

, 2012
Arsenic trioxide has been reported to inhibit cell growth and induce apoptotic cell death in many human cancer cells including breast cancer. However, the precise molecular mechanisms underlying the anti-tumor activity of arsenic trioxide are still ...
Ahmad, Aamir, Bao, Bin, Chen, Zhiwen, Li, Youjian, Mei, Chuanzhong, Miele, Lucio, Sarkar, Fazlul H, Wang, Zhiwei, Xia, Jun, Yang, Qingling   +9 more
core   +2 more sources

Successful treatment of acute promyelocytic leukemia in a patient undergoing hemodialysis with arsenic trioxide

Clinical Case Reports, 2021
A man undergoing hemodialysis was diagnosed with acute promyelocytic leukemia (APL). He received arsenic trioxide as a single agent and achieved complete molecular remission without severe adverse events.
Akiko Hashimoto, Yasuhiro Tanaka, Isaku Shinzato   +2 more
doaj   +1 more source