Results 11 to 20 of about 62,998 (285)

Efficacy and Safety of Artemisinin-Piperaquine for the Treatment of Uncomplicated Malaria: A Systematic Review

Frontiers in Pharmacology, 2020
ObjectiveThe World Health Organization recommends artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated malaria to improve the therapeutic efficacy and limit the choice of drug-resistant parasites.
Qi Wang, Yuanyuan Zou, Ziyi Pan, Hongying Zhang, Changsheng Deng, Yueming Yuan, Yueming Yuan, Jiawen Guo, Jiawen Guo, Yexiao Tang, Nadia Julie, Wanting Wu, Guoming Li, Mingqiang Li, Ruixiang Tan, Xinan Huang, Wenfeng Guo, Changqing Li, Qin Xu, Jianping Song   +19 more
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Erythrocyte membrane with CLIPPKF as biomimetic nanodecoy traps merozoites and attaches to infected red blood cells to prevent Plasmodium infection

Journal of Nanobiotechnology, 2023
Background Malaria remains a serious threat to global public health. With poor efficacies of vaccines and the emergence of drug resistance, novel strategies to control malaria are urgently needed.
Zhouqing He, Chuyi Yu, Ziyi Pan, Xiaobo Li, Xiangxiang Zhang, Qijing Huang, Xingcheng Liao, Jiaoting Hu, Feng Zeng, Li Ru, Wanlin Yu, Qin Xu, Jianping Song, Jianming Liang   +13 more
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Proceedings of Chemistry, Pharmacology, Pharmacokinetics and Synthesis of Biflavonoids

Molecules, 2021
Biflavonoids, composed of two monoflavonoid residues, occur naturally in angiosperms, bryophytes, ferns, and gymnosperms. More than 592 biflavonoids have been structurally elucidated, and they can be classified into two groups of C-C and C-linear ...
Xinqian He, Fan Yang, Xin’an Huang
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Safety and Efficacy of Adjunctive Therapy With Artesunate in the Treatment of Severe Malaria: A Systematic Review and Meta-Analysis

Frontiers in Pharmacology, 2020
Objective: The purpose of this meta-analysis of longitudinal studies is to determine the safety and efficacy of artesunate combined with other forms of adjunctive therapies for severe malaria.Methods: Following the PRISMA guidelines, we searched multiple
Yuanyuan Zou, Fei Tuo, Zhiqi Zhang, Jiawen Guo, Yueming Yuan, Yueming Yuan, Hongying Zhang, Zhiyong Xu, Ziyi Pan, Yexiao Tang, Changsheng Deng, Nadia Julie, Wanting Wu, Wenfeng Guo, Changqing Li, Xinan Huang, Qin Xu, Jianping Song, Qi Wang   +18 more
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Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani [PDF]

, 2020
A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm.
Amado, Patrícia, Cabral, Lília, Cojean, Sandrine, Cristiano, Maria De Lurdes, Loiseau, Philippe M., Pomel, Sébastien   +5 more
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Surveillance of the Efficacy of Artemisinin–Piperaquine in the Treatment of Uncomplicated Plasmodium falciparum Malaria Among Children Under 5 Years of Age in Est-Mono District, Togo, in 2017

Frontiers in Pharmacology, 2020
BackgroundMalaria is a major public health concern in Togo. The Est-Mono district of Togo has a population of 150,000. Accordingly, the Guangzhou University of Chinese Medicine, China and the Ministry of Health and Social Security, Togo launched a ...
Qi Wang, Zhenyan Zhang, Weisheng Yu, Chenguang Lu, Guoming Li, Ziyi Pan, Hongying Zhang, Wanting Wu, Tinah Atcha Oubou, Yueming Yuan, Yueming Yuan, Jiawen Guo, Jiawen Guo, Yuan Liang, Xinan Huang, Wenfeng Guo, Changqing Li, `Nadia Julie, Qin Xu, Logte Sanwogou, Jianping Song, Changsheng Deng   +21 more
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Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

Research, 2023
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after ...
Chong Qiu, Fei Xia, Junzhe Zhang, Qiaoli Shi, Yuqing Meng, Chen Wang, Huanhuan Pang, Liwei Gu, Chengchao Xu, Qiuyan Guo, Jigang Wang   +10 more
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Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia–reperfusion

Journal of Neuroinflammation, 2021
Background Celastrol (cel) was one of the earliest isolated and identified chemical constituents of Tripterygium wilfordii Hook. f. Based on a cel probe (cel-p) that maintained the bioactivity of the parent compound, the targets of cel in cerebral ...
Dan-Dan Liu, Piao Luo, Liwei Gu, Qian Zhang, Peng Gao, Yongping Zhu, Xiao Chen, Qiuyan Guo, Junzhe Zhang, Nan Ma, Jigang Wang   +10 more
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Combined chemical transformation and biological transformation of artemisinin: A facile approach to diverse artemisinin derivatives

Frontiers in Chemistry, 2023
Introduction: Artemisinin (1) is a milestone compound in malaria treatment, and it exhibits a broad scope of bioactivities. Herein, sequential chemo-reduction and biotransformation of artemisinin were undertaken to obtain a series of artemisinin ...
Xinna Gao, Xinna Gao, Yue Bai, Peng Sun, Huimin Gao, Lan Yang, Dong Zhang, Yifan Zhao, Yue Ma   +8 more
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Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver Injury via PKM2 Regulated Oxidative Stress

Metabolites, 2022
Tripterygium glycoside tablet (TGT), as a common clinical drug, can easily cause liver damage due to the narrow therapeutic window. Glycyrrhizic acid (GA) has a hepatoprotective effect, but the characteristics and mechanism of GA’s impact on TGT-induced ...
Qixin Wang, Yuwen Huang, Yu Li, Luyun Zhang, Huan Tang, Junzhe Zhang, Guangqing Cheng, Minghong Zhao, Tianming Lu, Qian Zhang, Piao Luo, Yinhua Zhu, Fei Xia, Ying Zhang, Dandan Liu, Chen Wang, Haiyan Li, Chong Qiu, Jigang Wang, Qiuyan Guo   +19 more
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