Results 11 to 20 of about 74,638 (327)

Artemisinin resistance in Plasmodium falciparum malaria. [PDF]

New England Journal of Medicine, 2009
BACKGROUND Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
A. Dondorp, F. Nosten, P. Yi, D. Das, A. P. Phyo, J. Tarning, K. Lwin., F. Ariey, Warunee Hanpithakpong, Sue J Lee, P. Ringwald, K. Silamut, M. Imwong, K. Chotivanich, Pharath Lim, T. Herdman, S. An, S. Yeung, P. Singhasivanon, N. Day, N. Lindegårdh, D. Socheat, N. White   +22 more
semanticscholar   +3 more sources

Discovery and repurposing of artemisinin

Frontiers of Medicine, 2022
Malaria is an ancient infectious disease that threatens millions of lives globally even today. The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in a paradigm shift and been recognized as the "best hope for the treatment of malaria" by World Health Organization.
Shi, Qiaoli, Xia, Fei, Wang, Qixin, Liao, Fulong, Guo, Qiuyan, Xu, Chengchao, Wang, Jigang   +6 more
openaire   +3 more sources

From Plant to Yeast—Advances in Biosynthesis of Artemisinin

Molecules, 2022
Malaria is a life-threatening disease. Artemisinin-based combination therapy (ACT) is the preferred choice for malaria treatment recommended by the World Health Organization.
Le Zhao, Yunhao Zhu, Haoyu Jia, Yongguang Han, Xiaoke Zheng, Min Wang, Weisheng Feng   +6 more
doaj   +2 more sources

Evidence of artemisinin-resistant malaria in western Cambodia. [PDF]

New England Journal of Medicine, 2008
To the Editor: Although artemisinins are potent and rapidly acting antimalarial drugs, their widespread use for treating patients with Plasmodium falciparum malaria raises the question of emerging drug resistance.1,2 Artemisinin monotherapy should not be
H. Noedl, Youry Se, K. Schaecher, Bryan L. Smith, D. Socheat, M. Fukuda   +5 more
semanticscholar   +2 more sources

Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea.

New England Journal of Medicine, 2023
BACKGROUND Although the clinical efficacy of antimalarial artemisinin-based combination therapies in Africa remains high, the recent emergence of partial resistance to artemisinin in Plasmodium falciparum on the continent is troubling, given the lack of ...
S. Mihreteab, Lucien Platon, Araia Berhane, Barbara H. Stokes, M. Warsame, Pascal Campagne, Alexis Criscuolo, Laurence Ma, Nathalie Petiot, Cécile Doderer-Lang, Eric Legrand, Kurt E. Ward, Assefash Zehaie Kassahun, P. Ringwald, D. Fidock, Didier Ménard   +15 more
semanticscholar   +1 more source

Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia

Nature Microbiology, 2023
Diagnosis and treatment of Plasmodium falciparum infections are required for effective malaria control and are pre-requisites for malaria elimination efforts; hence we need to monitor emergence, evolution and spread of drug- and diagnostics-resistant ...
A. Fola, S. Feleke, H. Mohammed, B. G. Brhane, C. Hennelly, A. Assefa, Rebecca M Crudal, E. Reichert, J. Juliano, J. Cunningham, H. Mamo, Hiwot Solomon, G. Tasew, B. Petros, J. Parr, J. Bailey   +15 more
semanticscholar   +1 more source

Evidence of Artemisinin-Resistant Malaria in Africa.

New England Journal of Medicine, 2021
BACKGROUND In the six Southeast Asian countries that make up the Greater Mekong Subregion, Plasmodium falciparum has developed resistance to derivatives of artemisinin, the main component of first-line treatments for malaria.
B. Balikagala, Naoyuki Fukuda, Mie Ikeda, Osbert T. Katuro, Shin-Ichiro Tachibana, M. Yamauchi, Walter Opio, Sakurako Emoto, D. A. Anywar, E. Kimura, N. Palacpac, E. Odongo-Aginya, M. Ogwang, T. Horii, Toshihiro Mita   +14 more
semanticscholar   +1 more source

Artemisinin attenuated ischemic stroke induced cell apoptosis through activation of ERK1/2/CREB/BCL-2 signaling pathway in vitro and in vivo

International Journal on Biological Sciences, 2022
Ischemic stroke is characterized by the presence of both brain ischemic and reperfusion-induced injuries in the brain, leading to neuronal dysfunction and death.
Tang-Ming Peng, Shuai Li, Linlin Liu, Chaoxian Yang, Mohd Farhan, Ligang Chen, Q. Su, Wenhua Zheng   +7 more
semanticscholar   +1 more source

Efficacy and Safety of Artemisinin-Piperaquine for the Treatment of Uncomplicated Malaria: A Systematic Review

Frontiers in Pharmacology, 2020
ObjectiveThe World Health Organization recommends artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated malaria to improve the therapeutic efficacy and limit the choice of drug-resistant parasites.
Qi Wang, Yuanyuan Zou, Ziyi Pan, Hongying Zhang, Changsheng Deng, Yueming Yuan, Yueming Yuan, Jiawen Guo, Jiawen Guo, Yexiao Tang, Nadia Julie, Wanting Wu, Guoming Li, Mingqiang Li, Ruixiang Tan, Xinan Huang, Wenfeng Guo, Changqing Li, Qin Xu, Jianping Song   +19 more
doaj   +1 more source

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

Communications Biology, 2022
The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions.
Lei Zhu, Rob W. van der Pluijm, M. Kucharski, Sourav Nayak, Jaishree Tripathi, N. White, Nicholas P J Day, A. Faiz, A. Phyo, C. Amaratunga, D. Lek, E. Ashley, F. Nosten, F. Smithuis, H. Ginsburg, L. von Seidlein, Khin Lin, M. Imwong, K. Chotivanich, M. Mayxay, M. Dhorda, Hoang Chau Nguyen, Thuy-Nhien Nguyen, Olivo Miotto, P. Newton, P. Jittamala, R. Tripura, S. Pukrittayakamee, T. Peto, T. Hien, A. Dondorp, Zbynek Bozdech   +31 more
semanticscholar   +1 more source