Results 21 to 30 of about 74,638 (327)

Proceedings of Chemistry, Pharmacology, Pharmacokinetics and Synthesis of Biflavonoids

Molecules, 2021
Biflavonoids, composed of two monoflavonoid residues, occur naturally in angiosperms, bryophytes, ferns, and gymnosperms. More than 592 biflavonoids have been structurally elucidated, and they can be classified into two groups of C-C and C-linear ...
Xinqian He, Fan Yang, Xin’an Huang
doaj   +1 more source

AaMYB108 is the core factor integrating light and jasmonic acid signaling to regulate artemisinin biosynthesis in Artemisia annua.

New Phytologist, 2022
Artemisinin, a sesquiterpene compound synthesized and stored in the glandular trichome of Artemisia annua leaves, has been used to treat malaria. Previous studies have shown that both light and jasmonic acid can promote the biosynthesis of artemisinin ...
Hang Liu, Ling Li, Xueqing Fu, Yongpeng Li, Tiantian Chen, Wei Qin, Xin Yan, Zhangkuanyu Wu, Lihui Xie, Sadaf-llyas Kayani, D. Hassani, Xiaofen Sun, K. Tang   +12 more
semanticscholar   +1 more source

Safety and Efficacy of Adjunctive Therapy With Artesunate in the Treatment of Severe Malaria: A Systematic Review and Meta-Analysis

Frontiers in Pharmacology, 2020
Objective: The purpose of this meta-analysis of longitudinal studies is to determine the safety and efficacy of artesunate combined with other forms of adjunctive therapies for severe malaria.Methods: Following the PRISMA guidelines, we searched multiple
Yuanyuan Zou, Fei Tuo, Zhiqi Zhang, Jiawen Guo, Yueming Yuan, Yueming Yuan, Hongying Zhang, Zhiyong Xu, Ziyi Pan, Yexiao Tang, Changsheng Deng, Nadia Julie, Wanting Wu, Wenfeng Guo, Changqing Li, Xinan Huang, Qin Xu, Jianping Song, Qi Wang   +18 more
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Surveillance of the Efficacy of Artemisinin–Piperaquine in the Treatment of Uncomplicated Plasmodium falciparum Malaria Among Children Under 5 Years of Age in Est-Mono District, Togo, in 2017

Frontiers in Pharmacology, 2020
BackgroundMalaria is a major public health concern in Togo. The Est-Mono district of Togo has a population of 150,000. Accordingly, the Guangzhou University of Chinese Medicine, China and the Ministry of Health and Social Security, Togo launched a ...
Qi Wang, Zhenyan Zhang, Weisheng Yu, Chenguang Lu, Guoming Li, Ziyi Pan, Hongying Zhang, Wanting Wu, Tinah Atcha Oubou, Yueming Yuan, Yueming Yuan, Jiawen Guo, Jiawen Guo, Yuan Liang, Xinan Huang, Wenfeng Guo, Changqing Li, `Nadia Julie, Qin Xu, Logte Sanwogou, Jianping Song, Changsheng Deng   +21 more
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Preventing antimalarial drug resistance with triple artemisinin-based combination therapies

medRxiv, 2022
Background. Increasing levels of artemisinin and partner drug resistance threaten malaria control and elimination globally. Triple artemisinin-based combination therapies (TACTs) which combine artemisinin derivatives with two partner drugs are ...
Tran Dang Nguyen, B. Gao, C. Amaratunga, M. Dhorda, T. N. Tran, N. White, A. Dondorp, M. F. Boni, R. Águas   +8 more
semanticscholar   +1 more source

Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

Research, 2023
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after ...
Chong Qiu, Fei Xia, Junzhe Zhang, Qiaoli Shi, Yuqing Meng, Chen Wang, Huanhuan Pang, Liwei Gu, Chengchao Xu, Qiuyan Guo, Jigang Wang   +10 more
doaj   +1 more source

Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia–reperfusion

Journal of Neuroinflammation, 2021
Background Celastrol (cel) was one of the earliest isolated and identified chemical constituents of Tripterygium wilfordii Hook. f. Based on a cel probe (cel-p) that maintained the bioactivity of the parent compound, the targets of cel in cerebral ...
Dan-Dan Liu, Piao Luo, Liwei Gu, Qian Zhang, Peng Gao, Yongping Zhu, Xiao Chen, Qiuyan Guo, Junzhe Zhang, Nan Ma, Jigang Wang   +10 more
doaj   +1 more source

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

Science, 2020
An artemisinin resistance mechanism Species of the malaria parasite Plasmodium live in red blood cells and possess a highly conserved gene called kelch13.
Jakob Birnbaum, Sarah Scharf, S. Schmidt, Ernst Jonscher, W. Hoeijmakers, Sven Flemming, C. G. Toenhake, Marius Schmitt, Ricarda Sabitzki, B. Bergmann, Ulrike Fröhlke, P. Mesén-Ramírez, Alexandra Blancke Soares, Hendrik Herrmann, R. Bártfai, T. Spielmann   +15 more
semanticscholar   +1 more source

Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani [PDF]

, 2020
A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm.
Amado, Patrícia, Cabral, Lília, Cojean, Sandrine, Cristiano, Maria De Lurdes, Loiseau, Philippe M., Pomel, Sébastien   +5 more
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Artemisinin resistance and malaria elimination: Where are we now?

Frontiers in Pharmacology, 2022
The emergence of artemisinin resistance is a major obstacle to the global malaria eradication/elimination programs. Artemisinin is a very fast-acting antimalarial drug and is the most important drug in the treatment of severe and uncomplicated malaria ...
B. Hanboonkunupakarn, J. Tarning, S. Pukrittayakamee, K. Chotivanich   +3 more
semanticscholar   +1 more source