Results 31 to 40 of about 74,638 (327)

Combined Transcriptome and Proteome Profiling for Role of pfEMP1 in Antimalarial Mechanism of Action of Dihydroartemisinin

Microbiology Spectrum, 2021
Malaria parasites induce morphological and biochemical changes in the membranes of parasite-infected red blood cells (iRBCs) for propagation. Artemisinin combination therapies are the first-line antiplasmodials in countries of endemicity.
Lina Chen, Zhongyuan Zheng, Hui Liu, Xi Wang, Shuiqing Qu, Yuanmin Yang, Shuoqiu Deng, Yu Zhang, Liu Tuo, Yongdan Zhao, Yujie Li   +10 more
doaj   +1 more source

Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NF-κB Signaling

International Journal of Molecular Sciences, 2022
The abnormal immune response is an early change in the pathogenesis of Alzheimer’s disease (AD). Microglial activation is a crucial regulator of the immune response, which contributes to progressive neuronal injury by releasing neurotoxic products ...
Xia Zhao, X. Huang, Chao Yang, Yizhou Jiang, Wenshu Zhou, Wenhua Zheng   +5 more
semanticscholar   +1 more source

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

Nature Communications, 2021
The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium falciparum K13, has compromised antimalarial efficacy and threatens the global malaria elimination campaign.
Sachel Mok, Barbara H. Stokes, Nina F. Gnädig, Leila S Ross, Tomas Yeo, C. Amaratunga, Erik L. Allman, L. Solyakov, A. Bottrill, Jaishree Tripathi, R. Fairhurst, M. Llinás, Zbynek Bozdech, A. Tobin, D. Fidock   +14 more
semanticscholar   +1 more source

Combined chemical transformation and biological transformation of artemisinin: A facile approach to diverse artemisinin derivatives

Frontiers in Chemistry, 2023
Introduction: Artemisinin (1) is a milestone compound in malaria treatment, and it exhibits a broad scope of bioactivities. Herein, sequential chemo-reduction and biotransformation of artemisinin were undertaken to obtain a series of artemisinin ...
Xinna Gao, Xinna Gao, Yue Bai, Peng Sun, Huimin Gao, Lan Yang, Dong Zhang, Yifan Zhao, Yue Ma   +8 more
doaj   +1 more source

Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms [PDF]

, 2012
BACKGROUND AND PURPOSE Widespread resistance to antimalarial drugs requires combination therapies with increasing risk of pharmacokinetic drugdrug interactions.
Alexander, Arnold, Asimus, Auerbach, Auerbach, Baes, Berman, Blättler, Burk, Burk, di Masi, Dring, Elsherbiny, Faucette, Gautam, Giao, Grace, Halgren, Hesse, Hoffart, Honda, Huey, Hustert, Jyrkkärinne, Kawamoto, Kerb, Khoo, Krey, Kyle, Lee, Maglich, Moore, Morris, Navaratnam, Nussler, Pan, Pissios, Ross, Sanner, Simonsson, Skinner-Adams, Svensson, Svärd, Wang, Ward, White, WHO, WHO, Windshügel, Wolbold, Xu, Zhang   +51 more
core   +1 more source

Neurotoxicity of Artemisinin Derivatives [PDF]

Clinical Infectious Diseases, 2006
tion to a recent letter published in this journal by Toovey [ 1 ] regarding the alleged neurotoxicity of the artemisinin derivatives. The letter was in response to a reply by Newton et al. [2] to a case reported by Franco-Paredes et al. [3]. This letter makes reference to our congress presentation [4], but Toovey has changed the title of our abstract ...
Adjei, George Obeng, Goka, Bamenla Q, Kurtzhals, Jørgen   +2 more
openaire   +4 more sources

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. [PDF]

, 2012
BACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
Khairnar, K, Krishna, S, Lau, R, Lepore, R, Pillai, DR, Staines, HM, Via, A   +6 more
core   +1 more source

Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver Injury via PKM2 Regulated Oxidative Stress

Metabolites, 2022
Tripterygium glycoside tablet (TGT), as a common clinical drug, can easily cause liver damage due to the narrow therapeutic window. Glycyrrhizic acid (GA) has a hepatoprotective effect, but the characteristics and mechanism of GA’s impact on TGT-induced ...
Qixin Wang, Yuwen Huang, Yu Li, Luyun Zhang, Huan Tang, Junzhe Zhang, Guangqing Cheng, Minghong Zhao, Tianming Lu, Qian Zhang, Piao Luo, Yinhua Zhu, Fei Xia, Ying Zhang, Dandan Liu, Chen Wang, Haiyan Li, Chong Qiu, Jigang Wang, Qiuyan Guo   +19 more
doaj   +1 more source

Development of artesunate intelligent prodrug liposomes based on mitochondrial targeting strategy

Journal of Nanobiotechnology, 2022
Breast cancer is the leading cause of cancer-related deaths in women and remains a formidable therapeutic challenge. Mitochondria participate in a myriad of essential cellular processes, such as metabolism, and are becoming an ideal target for cancer ...
Liwei Gu, Jiaxing Zhang, Dandan Liu, Jiayun Chen, Shuzhi Liu, Qing Peng, Ya Tian, Maobo Du, Junzhe Zhang, Wei Xiao, Shuo Shen, Jigang Wang   +11 more
doaj   +1 more source

GB1a Ameliorates Ulcerative Colitis via Regulation of the NF-κB and Nrf2 Signaling Pathways in an Experimental Model

Frontiers in Medicine, 2021
Ulcerative colitis (UC) is an inflammatory bowel disease. The intake of African Garcinia Kola nuts has been reported as a therapy for diarrhea and dysentery in the African population.
Yuanyuan Yu, Congmin Zheng, Xu Lu, Changsheng Deng, Changsheng Deng, Qin Xu, Qin Xu, Wenfeng Guo, Wenfeng Guo, Qingye Wu, Qi Wang, Changhui Liu, Xinan Huang, Xinan Huang, Jianping Song, Jianping Song   +15 more
doaj   +1 more source