Results 41 to 50 of about 74,638 (327)

Artemisinin Derivatives Inhibit Non-small Cell Lung Cancer Cells Through Induction of ROS-dependent Apoptosis/Ferroptosis

Journal of Cancer, 2021
Non-small cell lung cancer (NSCLC) is one of the major cancer-related causes of morbidity and mortality worldwide. Despite the progress in lung cancer treatment, there is still an urgent need to discover novel therapeutic agents for NSCLC.
Qiuting Zhang, Huimei Yi, Hui Yao, Lu Lu, Guangchun He, Mi Wu, Chanjuan Zheng, Ying Li, Sisi Chen, Lewei Li, Hongyuan Yu, Guifei Li, Xiaojun Tao, Shujun Fu, Xiyun Deng   +14 more
semanticscholar   +1 more source

Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials. [PDF]

, 2008
BACKGROUND: Artemisinin combination therapies (ACT), which are increasingly being introduced for treatment of Plasmodium falciparum malaria, are more effective against sexual stage parasites (gametocytes) than previous first-line antimalarials and ...
Bousema, Teun, Drakeley, Chris J, Ghani, Azra C, Okell, Lucy C, Sutherland, Colin J   +4 more
core   +3 more sources

AaWRKY9 contributes to light- and jasmonate-mediated to regulate the biosynthesis of artemisinin in Artemisia annua.

New Phytologist, 2021
Artemisinin, isolated from Artemisia annua L., is recommended as the preferred drug to fight malaria. Previous research showed that JA mediated promotion of artemisinin accumulation was dependent on light.
Xueqing Fu, B. Peng, D. Hassani, Lihui Xie, Hang Liu, Yongpeng Li, Tiantian Chen, Pin Liu, Yueli Tang, Ling Li, Jing-ya Zhao, Xiaofen Sun, K. Tang   +12 more
semanticscholar   +1 more source

Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria [PDF]

, 2009
With the availability of new preventive and curative interventions, global malaria control has been strengthened significantly in recent years. Drugs effective in reducing malaria gametocytaemia might contribute to local elimination and possible long ...
Coulibaly, Boubacar, Klose, Christina, Mansmann, Ulrich, Meissner, Peter E., Mockenhaupt, Frank P., Müller, Olaf, Schirmer, R. Heiner, Zoungrana, Augustin   +7 more
core   +1 more source

Spread of artemisinin resistance in Plasmodium falciparum malaria.

New England Journal of Medicine, 2014
BACKGROUND Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria.
E. Ashley, M. Dhorda, R. Fairhurst, C. Amaratunga, P. Lim, Seila Suon, Sokunthea Sreng, Jennifer M. Anderson, Sivanna Mao, Baramey Sam, Chantha Sopha, Char Meng Chuor, C. Nguon, S. Sovannaroth, S. Pukrittayakamee, P. Jittamala, K. Chotivanich, K. Chutasmit, C. Suchatsoonthorn, R. Runcharoen, T. Hien, Nguyen T Thuy-Nhien, N. V. Thanh, N. Phu, Y. Htut, K. Han, K. H. Aye, O. Mokuolu, Rasaq R Olaosebikan, O. Folaranmi, M. Mayxay, Maniphone Khanthavong, B. Hongvanthong, P. Newton, M. Onyamboko, C. Fanello, A. Tshefu, N. Mishra, N. Valecha, A. Phyo, F. Nosten, P. Yi, R. Tripura, S. Borrmann, M. Bashraheil, J. Peshu, M. A. Faiz, A. Ghose, M. Hossain, Rasheda Samad, M. R. Rahman, M. Hasan, Akhterul Islam, Olivo Miotto, R. Amato, B. MacInnis, J. Stalker, D. Kwiatkowski, Zbynek Bozdech, Atthanee Jeeyapant, P. Cheah, Tharisara Sakulthaew, Jeremy Chalk, B. Intharabut, K. Silamut, Sue J Lee, Benchawan Vihokhern, Chanon Kunasol, M. Imwong, J. Tarning, W. J. Taylor, S. Yeung, C. Woodrow, J. Flegg, D. Das, Jeffery L. Smith, M. Venkatesan, C. Plowe, K. Stepniewska, P. Guérin, A. Dondorp, N. Day, N. White   +82 more
semanticscholar   +1 more source

MEPicides: Potent antimalarial prodrugs targeting isoprenoid biosynthesis [PDF]

, 2017
The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol
Brothers, Robert C, Dowd, Cynthia S, Edwards, Rachel L, Hruz, Paul W, Kraft, Thomas E, Maron, Maxim I, Odom John, Audrey R, Tsang, Patricia S, Wang, Xu, Williamson, Kim C, Ziniel, Peter D   +10 more
core   +2 more sources

Transcriptome and Lipid Metabolomics-Based Discovery: Glycyrrhizic Acid Alleviates Tripterygium Glycoside Tablet-Induced Acute Liver Injury by Regulating the Activities of CYP and the Metabolism of Phosphoglycerides

Frontiers in Pharmacology, 2022
Background: Glycyrrhizic acid (GA) has been reported to be liver protective; however, the characters and underlying mechanisms of GA against tripterygium glycoside tablet (TGT)-induced acute liver injury remain unelucidated.Hypothesis/Purpose: We assumed
Qiaoli Shi, Qixin Wang, Jiayun Chen, Fei Xia, Chong Qiu, Min Li, Minghong Zhao, Minghong Zhao, Qian Zhang, Piao Luo, Tianming Lu, Ying Zhang, Liting Xu, Xueling He, Tianyu Zhong, Tianyu Zhong, Na Lin, Qiuyan Guo   +17 more
doaj   +1 more source

Artemisinin: current status

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994
The compounds derived from the Chinese medicinal plant qinghao (Artemisia annua) are the most rapidly acting of all antimalarial drugs. They are effective when given parenterally, orally or by suppository. No serious adverse effect has yet been reported in humans.
Nicholas J. White, Nicholas J. White, Nicholas J. White   +2 more
openaire   +3 more sources

Artemisinin and multidrug-resistant Plasmodium falciparum – a threat for malaria control and elimination

Current Opinion in Infectious Diseases, 2021
Purpose of review Artemisinin-based combination therapies (ACTs) are globally the first-line treatment for uncomplicated falciparum malaria and new compounds will not be available within the next few years.
M. Dhorda, C. Amaratunga, A. Dondorp
semanticscholar   +1 more source

Jasmonate‐ and abscisic acid‐activated AaGSW1‐AaTCP15/AaORA transcriptional cascade promotes artemisinin biosynthesis in Artemisia annua

Plant Biotechnology Journal, 2021
Summary Artemisinin, a sesquiterpene lactone widely used in malaria treatment, was discovered in the medicinal plant Artemisia annua. The biosynthesis of artemisinin is efficiently regulated by jasmonate (JA) and abscisic acid (ABA) via regulatory ...
Ya-Nan Ma, Dongbei Xu, Xin Yan, Zhangkuanyu Wu, Sadaf-Ilyas Kayani, Qian Shen, Xueqing Fu, Lihui Xie, Xiaolong Hao, D. Hassani, Ling Li, Hang Liu, Q. Pan, Zongyou Lv, Pin Liu, Xiaofen Sun, K. Tang   +16 more
semanticscholar   +1 more source