Results 51 to 60 of about 63,940 (276)

Plant Cellular and Molecular Biotechnology: Following Mariotti's Steps [PDF]

, 2019
This review is dedicated to the memory of Prof. Domenico Mariotti, who significantly contributed to establishing the Italian research community in Agricultural Genetics and carried out the first experiments of Agrobacterium-mediated plant genetic ...
Caretto, Sofia, Frugis, Giovanna, Giannino, Donato, Iannelli, Maria Adelaide, Mauro, Maria Luisa, Mele, Giovanni, Nicolodi, Chiara, Paolis, Angelo De, Rugini, Eddo, Silvestri, Cristian, Sparvoli, Francesca, Testone, Giulio   +11 more
core   +1 more source

Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics

Acta Pharmaceutica Sinica B, 2021
Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treatment of fibrosis.
David Dolivo, Pamela Weathers, Tanja Dominko   +2 more
openaire   +3 more sources

Making artemisinin☆

Phytochemistry, 2008
The possibilities for the production of the antimalarial artemisinin by biological and chemical means are explored. These include native biosynthesis, genetic modification of Artemisia annua and other plants, engineering of microbes, total and partial chemical synthesis and combinations of the above.
openaire   +3 more sources

Magnetic Nanoparticle-Based Ligand Replacement Strategy for Chemical Luminescence Determination of Cholesterol

Frontiers in Chemistry, 2020
Determination of serum cholesterol (Chol) is important for disease diagnosis, and has attracted great attention during the last few decades. Herein, a new magnetic nanoparticle-based ligand replacement strategy has been presented for chemical ...
Yalan Wu, Danfeng Peng, Zhiwen Qi, Jing Zhao, Wenyi Huang, Ying Zhang, Changhui Liu, Tao Deng, Fang Liu   +8 more
doaj   +1 more source

Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA

Military Medical Research, 2022
Background Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indispensable role, however, its ...
Peng Gao, Yan-Qing Liu, Wei Xiao, Fei Xia, Jia-Yun Chen, Li-Wei Gu, Fan Yang, Liu-Hai Zheng, Jun-Zhe Zhang, Qian Zhang, Zhi-Jie Li, Yu-Qing Meng, Yong-Ping Zhu, Huan Tang, Qiao-Li Shi, Qiu-Yan Guo, Ying Zhang, Cheng-Chao Xu, Ling-Yun Dai, Ji-Gang Wang   +19 more
doaj   +1 more source

Mass Drug Administration With Artemisinin-Piperaquine for the Elimination of Residual Foci of Malaria in São Tomé Island

Frontiers in Medicine, 2021
Background: Mass drug administration with artemisinin-piperaquine (AP-MDA) is being considered for elimination of residual foci of malaria in Democratic Republic of São Tomé and Principe.Methods: Three monthly rounds of AP-MDA were implemented from July ...
Mingqiang Li, Fei Tuo, Ruixiang Tan, Hongying Zhang, Shaoqin Zheng, Qi Wang, Qin Xu, Xinbing Yu, Fangli Lu, Zhibing Wu, Jun Huang, Herodes Sacramento Rampao, Carlos Alberto Bandeira D'almeida, Hong Yan, Jianping Song, Wenfeng Guo, Changsheng Deng   +16 more
doaj   +1 more source

Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract – possible synergistic and resistance mechanisms [PDF]

Artemisia annua hot water infusion (tea) has been used in in vitro experiments against P. falciparum malaria parasites to test potency relative to equivalent pure artemisinin.
A Belkaid, A De Donno, A Nemeikaitė-Čėnienė, ABS Sidhu, Alexander P. Gorka, Alexei A. Lapkin, AR Bilia, AV Pandey, B Tepe, B Zhang, BC Elford, CW Jefford, CW Wright, D Cao, E Hsu, E Hsu, EG Yordi, F Van der Kooy, FH Jansen, G Noratto, Gabriele Pradel, Guy C. Barker, H Wagner, H Wagner, H Wagner, HJ Woerdenbag, İ Gülçin, J Golenser, J Mouton, J Suberu, J Wang, J-G Xu, John O. Suberu, K Liu, K Rath, L Cui, L Vivas, L-H Wang, Lauren Jacobs, M Friedman, M Petersen, M Willcox, M Willcox, MC Berenbaum, N Acton, N Erkan, N Klonis, Neil Sullivan, P Miketova, Paul D. Roepe, PG Bray, PJ Weathers, PJ Weina, PK Agrawal, PM De Magalhaes, PM O’Neill, PT Lansbury, QL Fivelman, R Feng, RK Haynes, RK Haynes, RT Eastman, S De Ridder, T Carbonara, TN Bennett, U Eckstein-Ludwig, W Li, XC Ding, Z Bozdech   +68 more
core   +1 more source

Detection of persistent Plasmodium spp. infections in Ugandan children after artemether-lumefantrine treatment [PDF]

, 2014
During a longitudinal study investigating the dynamics of malaria in Ugandan lakeshore communities, a consistently high malaria prevalence was observed in young children despite regular treatment.
AARON ATUHAIRE, COLIN J. SUTHERLAND, Dinko, Felger, Fogg, GERALD MWESIGWA, J. RUSSELL STOTHARD, JOSÉ C. SOUSA-FIGUEIREDO, JUMA NABONGE, Katz, MARTHA BETSON, MOSES ADRIKO, MOSES ARINAITWE, NARCIS B. KABATEREINE   +13 more
core   +5 more sources

Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery

Journal of Experimental & Clinical Cancer Research, 2023
Background There are few effective medications for treating colorectal cancer and liver metastases (CRLM). The interactions among glycolysis, epithelial-mesenchymal transition (EMT), and immune microenvironment contribute to the progression of CRLM.
Li Long, Wei Xiong, Fenwang Lin, Jiazhen Hou, Guihua Chen, Taoxing Peng, Yihao He, Rui Wang, Qin Xu, Yongzhuo Huang   +9 more
doaj   +1 more source

Metabolite Profiling of Dihydroartemisinin in Blood of Plasmodium-Infected and Healthy Mice Using UPLC-Q-TOF-MSE

Frontiers in Pharmacology, 2021
Dihydroartemisinin (DHA) and its’ derivatives have been employed as the most powerful first-line drugs for malarial treatment for several decades. The metabolism of DHA has not been studied clearly.
Yifan Zhao, Yifan Zhao, Peng Sun, Peng Sun, Yue Ma, Yue Ma, Xiaoqiang Chang, Xiaoqiang Chang, Xingyu Chen, Xingyu Chen, Xin Ji, Xin Ji, Yue Bai, Yue Bai, Dong Zhang, Dong Zhang, Lan Yang, Lan Yang   +17 more
doaj   +1 more source