Results 61 to 70 of about 63,940 (276)

Health Worker Factors Associated with Prescribing of Artemisinin Combination Therapy for Uncomplicated Malaria in Rural Tanzania. [PDF]

, 2013
Improving malaria case management is partially dependent on health worker compliance with clinical guidelines. This study assessed health worker factors associated with correct anti-malarial prescribing practices at two sites in rural Tanzania.
Abdulla, Salim, Amuri, Mbaraka, de Savigny, Don, Kajungu, Dan, Khatib, Rashid A, Masanja, Irene M, Njozi, Mustafa, Selemani, Majige   +7 more
core   +4 more sources

The Protective Effects of Shengmai Formula Against Myocardial Injury Induced by Ultrafine Particulate Matter Exposure and Myocardial Ischemia are Mediated by the PI3K/AKT/p38 MAPK/Nrf2 Pathway

Frontiers in Pharmacology, 2021
Background and Purpose: Ultrafine particulate matter (UFPM) induces oxidative stress (OS) and is considered to be a risk factor of myocardial ischemia (MI). Shengmai formula (SMF) is a traditional Chinese medicine with antioxidant properties and has been
Lina Chen, Lina Chen, Yuan Guo, Yuan Guo, Shuiqing Qu, Shuiqing Qu, Kai Li, Kai Li, Ting Yang, Ting Yang, Yuanmin Yang, Yuanmin Yang, Zhongyuan Zheng, Zhongyuan Zheng, Hui Liu, Hui Liu, Xi Wang, Xi Wang, Shuoqiu Deng, Shuoqiu Deng, Yu Zhang, Yu Zhang, Xiaoxin Zhu, Xiaoxin Zhu, Yujie Li, Yujie Li   +25 more
doaj   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

From Plant to Yeast—Advances in Biosynthesis of Artemisinin

Molecules, 2022
Malaria is a life-threatening disease. Artemisinin-based combination therapy (ACT) is the preferred choice for malaria treatment recommended by the World Health Organization.
Le Zhao, Yunhao Zhu, Haoyu Jia, Yongguang Han, Xiaoke Zheng, Min Wang, Weisheng Feng   +6 more
doaj   +1 more source

Artemisinin: From Chinese Herbal Medicine to Modern Chemotherapy [PDF]

, 2019
Malaria is a disease that has blighted humankind since early times. The first antimalarial treatment available to Europeans was the dried bark of the cinchona tree from Peru. The main problem in its use was adulteration by other material.
Butler, Anthony
core   +1 more source

Saleability of Anti-malarials in Private Drug Shops in Muheza, Tanzania: A Baseline study in an era of assumed Artemisinin Ccombination Therapy (ACT). [PDF]

, 2011
Artemether-lumefantrine (ALu) replaced sulphadoxine-pymimethamine (SP) as the official first-line anti-malarial in Tanzania in November 2006. So far, artemisinin combination therapy (ACT) is contra-indicated during pregnancy by the national malaria ...
AM Rønn, B Wasunna, C Goodman, C Goodman, DS Tarimo, DS Tarimo, FM Ringsted, Frank M Ringsted, Ib C Bygbjerg, Isolide S Massawe, J Eriksen, M Alifrangis, M Alifrangis, Martha M Lemnge, Ministry of Health and Social Welfare URoT, MM Lemnge, MS Alilio, S Alba, S Alba, SE Nsimba, SE Nsimba, SE Nsimba, United Republic of Tanzania, VR Kamat, WE Harrington, World Health Organization, Z Premji   +26 more
core   +4 more sources

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Review of pyronaridine anti-malarial properties and product characteristics. [PDF]

, 2012
Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J, Borghini-Fuhrer, Isabelle, Craft, J Carl, Croft, Simon L, Duparc, Stephan, Fleckenstein, Lawrence, Rim, Han-Jong, Shin, Chang-Sik   +7 more
core   +2 more sources

STING deficiency promotes motor recovery in mice following brachial plexus root avulsion

Animal Models and Experimental Medicine, EarlyView.
STING deficiency can increase the body weight, promote motor recovery, decrease MN death, inhibit pyroptosis and neuroinflammation, increase remyelination, and reduce the atrophy of the biceps brachii in mice with BPRA. Abstract Background Brachial plexus root avulsion (BPRA), a well‐known form of peripheral nerve injury, results in motor function loss
Yu Peng, Ying Zhang, Shenhui Yang, Lu He, Shuangxi Chen   +4 more
wiley   +1 more source

Fu-zi decoction attenuate rheumatoid arthritis in vivo and in vitro by modulating RANK/RANKL signaling pathway

Frontiers in Pharmacology
BackgroundFu-zi decoction (FZD) has a long history of application for treating Rheumatoid arthritis (RA) as a classic formulation. However, its underlying mechanisms have not been fully elucidated.
Zhenzhen Pan, Zhenzhen Pan, Fangchan Li, Yujie Xu, Huimin Ye, Jiahui Liu, Zhenhua Wang, Changsheng Deng, Jianping Song, Manxue Mei, Changqing Li   +10 more
doaj   +1 more source