Results 61 to 70 of about 74,638 (327)

NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination.

, 2010
We characterized vaccine-induced cellular responses to rabies virus in naive adult volunteers. Contrary to current paradigms, we observed potent and prolonged in vitro NK cell cytokine production and degranulation responses after restimulation of PBMCs ...
Behrens, Ron H, Fooks, Anthony R, Horowitz, Amir, Okell, Lucy, Riley, Eleanor M   +4 more
core   +1 more source

Development of an Organoautocatalyzed Double σ‐Bond C(sp2)‐N Transamination Metathesis Reaction

Angewandte Chemie, EarlyView.
Organoautocatalyzed transamination metathesis of cyclic tertiary amines is disclosed as a high‐yielding, scalable reaction that proceeds under mild, catalyst‐free conditions. It operates via a multi‐step domino reaction mechanism, where an in situ‐formed pyrrolidinium salt functions as a HBD organoautocatalyst.
Volker Klein, Florian Schuster, Jonas Amthor, Harald Maid, Prabhakar Bijalwan, Fahmi Himo, Stefano Santoro, Svetlana B. Tsogoeva   +7 more
wiley   +2 more sources

Magnetic Nanoparticle-Based Ligand Replacement Strategy for Chemical Luminescence Determination of Cholesterol

Frontiers in Chemistry, 2020
Determination of serum cholesterol (Chol) is important for disease diagnosis, and has attracted great attention during the last few decades. Herein, a new magnetic nanoparticle-based ligand replacement strategy has been presented for chemical ...
Yalan Wu, Danfeng Peng, Zhiwen Qi, Jing Zhao, Wenyi Huang, Ying Zhang, Changhui Liu, Tao Deng, Fang Liu   +8 more
doaj   +1 more source

The Protective Effects of Shengmai Formula Against Myocardial Injury Induced by Ultrafine Particulate Matter Exposure and Myocardial Ischemia are Mediated by the PI3K/AKT/p38 MAPK/Nrf2 Pathway

Frontiers in Pharmacology, 2021
Background and Purpose: Ultrafine particulate matter (UFPM) induces oxidative stress (OS) and is considered to be a risk factor of myocardial ischemia (MI). Shengmai formula (SMF) is a traditional Chinese medicine with antioxidant properties and has been
Lina Chen, Lina Chen, Yuan Guo, Yuan Guo, Shuiqing Qu, Shuiqing Qu, Kai Li, Kai Li, Ting Yang, Ting Yang, Yuanmin Yang, Yuanmin Yang, Zhongyuan Zheng, Zhongyuan Zheng, Hui Liu, Hui Liu, Xi Wang, Xi Wang, Shuoqiu Deng, Shuoqiu Deng, Yu Zhang, Yu Zhang, Xiaoxin Zhu, Xiaoxin Zhu, Yujie Li, Yujie Li   +25 more
doaj   +1 more source

Making artemisinin☆

Phytochemistry, 2008
The possibilities for the production of the antimalarial artemisinin by biological and chemical means are explored. These include native biosynthesis, genetic modification of Artemisia annua and other plants, engineering of microbes, total and partial chemical synthesis and combinations of the above.
openaire   +3 more sources

Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

eLife, 2020
Antimalarial drug resistance has historically arisen through convergent de novo mutations in Plasmodium falciparum parasite populations in Southeast Asia and South America.
L. Mathieu, H. Cox, A. Early, Sachel Mok, Y. Lazrek, Jeanne-Celeste Paquet, M. Ade, N. Lucchi, Quacy Grant, V. Udhayakumar, Jean S F Alexandre, M. Demar, P. Ringwald, D. Neafsey, D. Fidock, L. Musset   +15 more
semanticscholar   +1 more source

Lead clinical and pre-clinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations [PDF]

, 2014
To achieve malarial elimination we must employ interventions that reduce the exposure of human populations to infectious mosquitoes. To this end, numerous anti-malarial drugs are under assessment in a variety of transmission-blocking assays which fail to
Blagborough, A.M., Brock, P.M., Churcher, T.S., Delves, M.J., Gething, P.W., Ghani, A.C., Leroy, D., Sala, K.A., Sinden, R.E., Upton, L.M.   +9 more
core   +4 more sources

Metabolite Profiling of Dihydroartemisinin in Blood of Plasmodium-Infected and Healthy Mice Using UPLC-Q-TOF-MSE

Frontiers in Pharmacology, 2021
Dihydroartemisinin (DHA) and its’ derivatives have been employed as the most powerful first-line drugs for malarial treatment for several decades. The metabolism of DHA has not been studied clearly.
Yifan Zhao, Yifan Zhao, Peng Sun, Peng Sun, Yue Ma, Yue Ma, Xiaoqiang Chang, Xiaoqiang Chang, Xingyu Chen, Xingyu Chen, Xin Ji, Xin Ji, Yue Bai, Yue Bai, Dong Zhang, Dong Zhang, Lan Yang, Lan Yang   +17 more
doaj   +1 more source

Tackling resistance: Emerging antimalarials and new parasite targets in the era of elimination [version 1; referees: 2 approved] [PDF]

, 2018
Malaria remains a significant contributor to global human mortality, and roughly half the world’s population is at risk for infection with Plasmodium spp. parasites.
Matthews, Emily S, Odom John, Audrey R
core   +2 more sources

A Temporizing Solution to “Artemisinin Resistance” [PDF]

New England Journal of Medicine, 2019
A Temporizing Solution to “Artemisinin Resistance” Three-day therapeutic courses are losing their efficacy against malarial parasites in the Greater Mekong Subregion. But continued rational and strategic use of artemisinin combination treatments is the best, and possibly the only, solution for the foreseeable future.
Chan, X-HS, White, NJ, Hien, TT
openaire   +6 more sources