Results 61 to 70 of about 62,998 (285)

Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase

Advanced Science, EarlyView.
Overview of Sructure, Multienzyme‐mimicking Activity and Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase. Abstract Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis.
Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu   +9 more
wiley   +1 more source

Fu-zi decoction attenuate rheumatoid arthritis in vivo and in vitro by modulating RANK/RANKL signaling pathway

Frontiers in Pharmacology
BackgroundFu-zi decoction (FZD) has a long history of application for treating Rheumatoid arthritis (RA) as a classic formulation. However, its underlying mechanisms have not been fully elucidated.
Zhenzhen Pan, Zhenzhen Pan, Fangchan Li, Yujie Xu, Huimin Ye, Jiahui Liu, Zhenhua Wang, Changsheng Deng, Jianping Song, Manxue Mei, Changqing Li   +10 more
doaj   +1 more source

Research advancements and evaluation of multifactor‐induced murine models for gastric cancer

Animal Models and Experimental Medicine, EarlyView.
Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang, Liang Zhang, Weixu Feng, Wanfeng Liu, Xiangyang Xue, Shiyu Feng   +5 more
wiley   +1 more source

Access to Artemisinin-Based Anti-Malarial Treatment and its Related Factors in Rural Tanzania. [PDF]

, 2013
Artemisinin-based combination treatment (ACT) has been widely adopted as one of the main malaria control strategies. However, its promise to save thousands of lives in sub-Saharan Africa depends on how effective the use of ACT is within the routine ...
A Bhattarai, Anonymous, Anonymous, B Greenwood, BP Mmbando, D de Savigny, D Schellenberg, Dan Kajungu, Don de Savigny, DS Tarimo, E Rutta, EA Okiro, Gumi A Mrisho, H Reyburn, IM Masanja, Irene Kuepfer, Irene M Masanja, JA Schellenberg, JR Armstrong Schellenberg, JR Schellenberg, JR Schellenberg, KI Barnes, KP Paaijmans, M Otten, M Tanner, M Tanner, M Tipke, Majige Selemani, Mbaraka Amuri, MM Nyunt, Mustafa H Njozi, MW Hetzel, NC Kakwani, P Gething, P Smithson, P Tugwell, PL Alonso, PMI, R Feachem, R Khatib, Rashid A Khatib, S Abdulla, S Alba, S Alba, S McCombie, Salim M Abdulla, TR Leahy, V D'Acremont, V D’Acremont, W Deressa, W Prudhomme O’Meara, WHO   +51 more
core   +4 more sources

STING deficiency promotes motor recovery in mice following brachial plexus root avulsion

Animal Models and Experimental Medicine, EarlyView.
STING deficiency can increase the body weight, promote motor recovery, decrease MN death, inhibit pyroptosis and neuroinflammation, increase remyelination, and reduce the atrophy of the biceps brachii in mice with BPRA. Abstract Background Brachial plexus root avulsion (BPRA), a well‐known form of peripheral nerve injury, results in motor function loss
Yu Peng, Ying Zhang, Shenhui Yang, Lu He, Shuangxi Chen   +4 more
wiley   +1 more source

Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea [PDF]

, 2023
Selam Mihreteab, Lucien Platon, Araia Berhane, Barbara H. Stokes, Marian Warsame, Pascal Campagne, Alexis Criscuolo, Laurence Ma, Nathalie Petiot, Cécile Doderer-Lang, Eric Legrand, Kurt E. Ward, A Kassahun, Pascal Ringwald, David A. Fidock, Didier Ménard   +15 more
openalex   +1 more source

The spread of antimalarial drug resistance: A mathematical model with practical implications for ACT drug policies [PDF]

, 2008
Most malaria-endemic countries are implementing a change in antimalarial drug policy to artemisinin combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Arjen Dondorp, Ian Hastings, Nicholas Day, Nicholas White, Shunmay Yeung, Wirichada Pongtavornpinyo   +5 more
core   +1 more source

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children. [PDF]

, 2008
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy.
A Yeka, B Greenhouse, CH Sibley, E Depoortere, Eleanor Turyakira, Elizabeth A Ashley, F Grandesso, Francesco Checchi, Grant Dorsey, H Bukirwa, Hasifa Bukirwa, I van den Broek, I Zongo, I Zongo, Ingrid van den Broek, Issaka Zongo, Jean-Paul Guthmann, JP Guthmann, JP Guthmann, JP Guthmann, K Mugittu, K Mugittu, K Stepniewska, K Stepniewska, Loretxu Pinoges, M Bonnet, Michel van Herp, N Bakyaita, NJ White, Pedro Pablo Palma Urruta, Piero Olliaro, PO Olliaro, RN Price, S Hamour, SG Staedke, Suna Balkan, TD Swarthout, Walter R Taylor, WJ Collins, World Health Organization, World Health Organization, World Health Organization, World Health Organization, World Health Organization   +43 more
core   +5 more sources

Process development priorities for scaling up direct microbial conversion of sugars into value‐added biochemicals

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract The study identified process development priorities toward the feasible production of five value‐added biochemicals in a sugarcane biorefinery based on achievable bioconversion performances. Multiple process scenarios using A‐molasses as feedstock were simulated in Aspen Plus® via direct microbial conversions.
Manasseh K. Sikazwe, Jeanne Louw, Johann F. Görgens   +2 more
wiley   +1 more source

Reproductive and Developmental Toxicity Assessment of Human Umbilical Cord Mesenchymal Stem Cells in Rats

Frontiers in Cell and Developmental Biology, 2022
Objective: Human umbilical cord mesenchymal stem cells (hUC-MSCs) have shown very attractive potential in clinical applications for the treatment of various diseases. However, the data about the reproductive and developmental toxicity of hUC-MSCs remains
Xiaobo Li, Xiaobo Li, Qijing Huang, Xiangxiang Zhang, Changfeng Xie, Muyun Liu, Yueming Yuan, Yueming Yuan, Jianjia Feng, Haoyu Xing, Li Ru, Li Ru, Zheng Yuan, Zhiyong Xu, YaoXiang Yang, Yan Long, Chengfeng Xing, Jianping Song, Jianping Song, Xiang Hu, Qin Xu, Qin Xu   +21 more
doaj   +1 more source