Results 1 to 10 of about 8,416 (212)

Artemisinins [PDF]

Postgraduate Medical Journal, 2005
Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of ...
Haynes, RK, Krishna, S, Woodrow, CJ
core   +7 more sources

Artemisinins inhibit oral candidiasis caused by Candida albicans through the repression on its hyphal development [PDF]

International Journal of Oral Science, 2023
Candida albicans is the most abundant fungal species in oral cavity. As a smart opportunistic pathogen, it increases the virulence by switching its forms from yeasts to hyphae and becomes the major pathogenic agent for oral candidiasis.
Xiaoyue Liang, Ding Chen, Jiannan Wang, Binyou Liao, Jiawei Shen, Xingchen Ye, Zheng Wang, Chengguang Zhu, Lichen Gou, Xinxuan Zhou, Lei Cheng, Biao Ren, Xuedong Zhou   +12 more
doaj   +2 more sources

ER Stress Induced by Artemisinin and Its Derivatives Determines the Susceptibility to Their Synergistic Apoptotic Killing With TRAIL [PDF]

Cancer Medicine
Aim Artemisinins are a class of antimalarial drugs that are lately being researched for their antitumor activity. We previously reported that artesunate, an artemisinin derivative, can induce ferroptosis and enhance TRAIL (Tumor necrosis factor‐Related ...
Snigdha Bhowmick, Yong J. Lee
doaj   +2 more sources

The contrasting effects of two antimalarial drugs on insulin secretion [PDF]

Cellular and Molecular Life Sciences
Quinolines and artemisinins are the two most important antimalarial drugs worldwide. In addition to antimalarial effects, quinine has been extensively documented to directly stimulate insulin secretion, potentially causing hypoglycemia in malaria ...
Jing Lu, Fengran Xiong, Qianrui Zhang, Ruxuan Zhao, Chenyang Zhang, Gang Wei, Jinkui Yang   +6 more
doaj   +2 more sources

Profiling of the anti-malarial drug candidate SC83288 against artemisinins in Plasmodium falciparum [PDF]

Malaria Journal, 2018
Background The increased resistance of the human malaria parasite Plasmodium falciparum to currently employed drugs creates an urgent call for novel anti-malarial drugs.
Maëlle Duffey, Cecilia P. Sanchez, Michael Lanzer   +2 more
doaj   +3 more sources

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections [PDF]

Malaria Journal, 2012
Background Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins. Methods Plasmodium falciparum
Pillai Dylan R, Lau Rachel, Khairnar Krishna, Lepore Rosalba, Via Allegra, Staines Henry M, Krishna Sanjeev   +6 more
doaj   +2 more sources

Artemisinin-resistant malaria. [PDF]

Clin Microbiol Rev
SUMMARY The artemisinin antimalarials are the cornerstone of current malaria treatment. The development of artemisinin resistance in Plasmodium falciparum poses a major threat to malaria control and elimination.
White NJ, Chotivanich K.
europepmc   +4 more sources

Treatment Failure and Post-Artesunate Delayed Haemolysis in a Returned Traveller From Uganda With Partially Drug-Resistant Severe Plasmodium falciparum Malaria. [PDF]

Med J Aust
ABSTRACT A man aged in his 40s, recently returned from Uganda, was hospitalised with Plasmodium falciparum malaria, with hyperparasitaemia of ~1.5 × 106 parasites/μL (26%). He received intravenous artesunate followed by artemether–lumefantrine. However, parasite clearance was delayed, and despite a negative blood film following treatment, the patient ...
Travis J, McCarthy K, Chapman P, Huang L, Tan A, Cheng Q, Barber BE.   +6 more
europepmc   +2 more sources

Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background [PDF]

Nature Communications
The emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment.
Sourav Nayak, Thomas J. Peto, Michal Kucharski, Rupam Tripura, James J. Callery, Duong Tien Quang Huy, Mathieu Gendrot, Dysoley Lek, Ho Dang Trung Nghia, Rob W. van der Pluijm, Nguyen Dong, Le Thanh Long, Ranitha Vongpromek, Huy Rekol, Nguyen Hoang Chau, Olivo Miotto, Mavuto Mukaka, Mehul Dhorda, Lorenz von Seidlein, Mallika Imwong, Xavier Roca, Nicholas P. J. Day, Nicholas J. White, Arjen M. Dondorp, Zbynek Bozdech   +24 more
doaj   +2 more sources

Molecular Markers of Antimalarial Drug Resistance in Plasmodium falciparum From Kumasi, Ghana, 2023. [PDF]

Trop Med Int Health
ABSTRACT Objectives Artemisinin partial resistance has emerged in East Africa and is feared to spread across the continent, potentially compromising artemisinin‐based combination treatment. Molecular markers can serve as early warning signals for the development of specific drug resistance.
Kegya AD, Oppong E, Darko E, Boateng KA, Phillips RO, Heinemann M, Ramharter M, Igiraneza C, Ndoli JM, Mockenhaupt FP, van Loon W.   +10 more
europepmc   +2 more sources