Results 1 to 10 of about 15,257 (261)

Artemisinins [PDF]

Postgraduate Medical Journal, 2005
Abstract Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of clinically important resistance.
Woodrow, CJ, Haynes, RK, Krishna, S.
openaire   +7 more sources

Artemisinins inhibit oral candidiasis caused by Candida albicans through the repression on its hyphal development [PDF]

International Journal of Oral Science, 2023
Candida albicans is the most abundant fungal species in oral cavity. As a smart opportunistic pathogen, it increases the virulence by switching its forms from yeasts to hyphae and becomes the major pathogenic agent for oral candidiasis.
Xiaoyue Liang, Ding Chen, Jiannan Wang, Binyou Liao, Jiawei Shen, Xingchen Ye, Zheng Wang, Chengguang Zhu, Lichen Gou, Xinxuan Zhou, Lei Cheng, Biao Ren, Xuedong Zhou   +12 more
doaj   +2 more sources

ER Stress Induced by Artemisinin and Its Derivatives Determines the Susceptibility to Their Synergistic Apoptotic Killing With TRAIL [PDF]

Cancer Medicine
Aim Artemisinins are a class of antimalarial drugs that are lately being researched for their antitumor activity. We previously reported that artesunate, an artemisinin derivative, can induce ferroptosis and enhance TRAIL (Tumor necrosis factor‐Related ...
Snigdha Bhowmick, Yong J. Lee
doaj   +2 more sources

The contrasting effects of two antimalarial drugs on insulin secretion [PDF]

Cellular and Molecular Life Sciences
Quinolines and artemisinins are the two most important antimalarial drugs worldwide. In addition to antimalarial effects, quinine has been extensively documented to directly stimulate insulin secretion, potentially causing hypoglycemia in malaria ...
Jing Lu, Fengran Xiong, Qianrui Zhang, Ruxuan Zhao, Chenyang Zhang, Gang Wei, Jinkui Yang   +6 more
doaj   +2 more sources

Artemisinin-resistant malaria. [PDF]

Clin Microbiol Rev
SUMMARY The artemisinin antimalarials are the cornerstone of current malaria treatment. The development of artemisinin resistance in Plasmodium falciparum poses a major threat to malaria control and elimination.
White NJ, Chotivanich K.
europepmc   +4 more sources

Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background [PDF]

Nature Communications
The emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment.
Sourav Nayak, Thomas J. Peto, Michal Kucharski, Rupam Tripura, James J. Callery, Duong Tien Quang Huy, Mathieu Gendrot, Dysoley Lek, Ho Dang Trung Nghia, Rob W. van der Pluijm, Nguyen Dong, Le Thanh Long, Ranitha Vongpromek, Huy Rekol, Nguyen Hoang Chau, Olivo Miotto, Mavuto Mukaka, Mehul Dhorda, Lorenz von Seidlein, Mallika Imwong, Xavier Roca, Nicholas P. J. Day, Nicholas J. White, Arjen M. Dondorp, Zbynek Bozdech   +24 more
doaj   +2 more sources

Repurposing of anti-malarial drugs for the treatment of tuberculosis: realistic strategy or fanciful dead end? [PDF]

Malaria Journal
Background Drug repurposing offers a strategic alternative to the development of novel compounds, leveraging the known safety and pharmacokinetic profiles of medications, such as linezolid and levofloxacin for tuberculosis (TB).
Thomas Hanscheid, Claire Ruiz del Portal Luyten, Sabine M. Hermans, Martin P. Grobusch   +3 more
doaj   +2 more sources

Artemisinin [PDF]

Chemie in unserer Zeit, 2014
AbstractArtemisinin ist der modernste Wirkstoff gegen Malaria, eine Infektionskrankheit, die den Menschen durch seine gesamte Entwicklungsgeschichte begleitete. Experimentelle Hinweise auf antike Malaria‐Epidemien gelangen durch Vervielfältigung von DNA‐Fragmenten des Erregers mit Hilfe der Polymerasekettenreaktion und dem Abgleich mit dem inzwischen ...
Paul May, Simon Cotton
  +7 more sources

The Antagonizing Role of Heme in the Antimalarial Function of Artemisinin: Elevating Intracellular Free Heme Negatively Impacts Artemisinin Activity in Plasmodium falciparum

Molecules, 2022
The rich source of heme within malarial parasites has been considered to underly the action specificity of artemisinin. We reasoned that increasing intraparasitic free heme levels might further sensitize the parasites to artemisinin.
Pan Zhu, Bing Zhou
doaj   +1 more source

Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics

Acta Pharmaceutica Sinica B, 2021
Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treatment of fibrosis.
David Dolivo, Pamela Weathers, Tanja Dominko   +2 more
openaire   +3 more sources