Results 31 to 40 of about 2,312 (140)

Viral RNA load and histological changes in tissues following experimental infection with an arterivirus of possums (wobbly possum disease virus)

Virology, 2018
Tissues from Australian brushtail possums (Trichosurus vulpecula) that had been experimentally infected with wobbly possum disease (WPD) virus (WPDV) were examined to elucidate pathogenesis of WPDV infection. Mononuclear inflammatory cell infiltrates were present in livers, kidneys, salivary glands and brains of WPD-affected possums.
Julia Giles, Matthew Perrott, Wendi Roe, Kshitiz Shrestha, Danielle Aberdein, Patrick Morel, Magdalena Dunowska   +6 more
openaire   +2 more sources

Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles [PDF]

, 2013
Coronaviruses (CoV), like other positive-stranded RNA viruses, redirect and rearrange host cell membranes for use as part of the viral genome replication and transcription machinery.
Baliji, Barretto, Beachboard, Centers for Disease Control and Prevention, Chan, Clementz, Cornillez-Ty, Cottam, de Groot, den Boon, den Boon, Drosten, Gadlage, Giansanti, Gosert, Hagemeijer, Hagemeijer, Hagemeijer, Harcourt, Imbert, Kanjanahaluethai, Kanjanahaluethai, Knoops, Ksiazek, Miller, Netherton, Neuman, Oostra, Oostra, Pasternak, Pedersen, Perlman, Posthuma, Poutanen, Prentice, Prentice, Reggiori, Salonen, Sawicki, Schmidt, Snijder, Snijder, Snijder, Sparks, Stertz, Suhy, Ulasli, Ulferts, van den Worm, Zaki, Ziebuhr   +50 more
core   +1 more source

Myristoylation of the arterivirus E protein: the fatty acid modification is not essential for membrane association but contributes significantly to virus infectivity

Journal of General Virology, 2009
The envelope of equine arteritis virus (EAV) contains two glycoprotein complexes (GP2b/GP3/GP4 and GP5/M) and the small, non-glycosylated E protein. As E is essential for the production of infectious progeny but dispensable for assembly and release of virus-like particles, it probably mediates virus entry into cells, putatively in concert with the GP2b/
Bastian, Thaa, Aleksander, Kabatek, Jessika C, Zevenhoven-Dobbe, Eric J, Snijder, Andreas, Herrmann, Michael, Veit   +5 more
openaire   +2 more sources

Apoptosis in the lungs of pigs infected with porcine reproductive and respiratory syndrome virus and associations with the production of apoptogenic cytokines [PDF]

, 2003
International audienceApoptosis was studied in the lungs of pigs during an infection with a European strain of porcine reproductive and respiratory syndrome virus (PRRSV) and it was examined if cytokines were involved in the induction of apoptosis ...
Labarque, Geoffrey, Nauwynck, Hans, Pensaert, Maurice, Van Gucht, Steven, Van Reeth, Kristien   +4 more
core   +3 more sources

Transcriptome Analysis Reveals Dynamic Gene Expression Profiles in Porcine Alveolar Macrophages in Response to the Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important swine pathogens and causes reproductive failure in sows and respiratory disease in growing pigs. PRRSV mainly infects porcine alveolar macrophages (PAMs), leading to the subversion of innate and adaptive immunity of pigs.
Nanfang Zeng, Cong Wang, Siyu Liu, Qi Miao, Lei Zhou, Xinna Ge, Jun Han, Xin Guo, Hanchun Yang, Yanjin Zhang   +9 more
wiley   +1 more source

Porcine Reproductive and Respiratory Syndrome Virus Induces IL‐1β Production Depending on TLR4/MyD88 Pathway and NLRP3 Inflammasome in Primary Porcine Alveolar Macrophages

Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been devastating the swine industry worldwide since the late 1980s. Previous studies have reported that PRRSV infection induced the production of IL‐1β. However, the cellular sensors and signaling pathways involved in this process have not been elucidated yet.
Jing Bi, Shuang Song, Liurong Fang, Dang Wang, Huiyuan Jing, Li Gao, Yidong Cai, Rui Luo, Huanchun Chen, Shaobo Xiao, Vera L. Petricevich   +10 more
wiley   +1 more source

Comparison of Host Immune Responses to Homologous and Heterologous Type II Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Challenge in Vaccinated and Unvaccinated Pigs

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Porcine reproductive and respiratory syndrome (PRRS) is a high‐consequence animal disease with current vaccines providing limited protection from infection due to the high degree of genetic variation of field PRRS virus. Therefore, understanding host immune responses elicited by different PRRSV strains will facilitate the development of more effective ...
X. Li, A. Galliher-Beckley, L. Pappan, B. Trible, M. Kerrigan, A. Beck, R. Hesse, F. Blecha, J. C. Nietfeld, R. R. Rowland, J. Shi, Denis Archambault   +11 more
wiley   +1 more source

Equine Arteritis Virus Does Not Induce Interferon Production in Equine Endothelial Cells: Identification of Nonstructural Protein 1 as a Main Interferon Antagonist

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
The objective of this study was to investigate the effect of equine arteritis virus (EAV) on type I interferon (IFN) production. Equine endothelial cells (EECs) were infected with the virulent Bucyrus strain (VBS) of EAV and expression of IFN‐β was measured at mRNA and protein levels by quantitative real‐time RT‐PCR and IFN bioassay using vesicular ...
Yun Young Go, Yanhua Li, Zhenhai Chen, Mingyuan Han, Dongwan Yoo, Ying Fang, Udeni B. R. Balasuriya, Denis Archambault   +7 more
wiley   +1 more source

The Effects of the Context‐Dependent Codon Usage Bias on the Structure of the nsp1α of Porcine Reproductive and Respiratory Syndrome Virus

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
The information about the crystal structure of porcine reproductive and respiratory syndrome virus (PRRSV) leader protease nsp1α is available to analyze the roles of tRNA abundance of pigs and codon usage of the nsp1α gene in the formation of this protease.
Yao-zhong Ding, Ya-nan You, Dong-jie Sun, Hao-tai Chen, Yong-lu Wang, Hui-yun Chang, Li Pan, Yu-zhen Fang, Zhong-wang Zhang, Peng Zhou, Jian-liang Lv, Xin-sheng Liu, Jun-jun Shao, Fu-rong Zhao, Tong Lin, Laszlo Stipkovits, Zygmunt Pejsak, Yong-guang Zhang, Jie Zhang, Hongwei Wang   +19 more
wiley   +1 more source

Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses [PDF]

, 2014
Studies have found that a cluster of duplicated gene loci encoding the interferon-inducible transmembrane proteins (IFITMs) family have antiviral activity against several viruses, including influenza A virus. The gene family has 5 and 7 members in humans
Harhay, Gregory P., Jiang, Zhihua, Lager, Kelly M., Miller, Laura C., Sang, Yongming   +4 more
core   +1 more source