Results 41 to 50 of about 30,074 (243)

Prevention of plant crown gall tumor development by the anti-malarial artesunate of Artemisia annua

Journal für Kulturpflanzen, 2009
The antimalarial drug artesunate, a sesquiterpene trioxane lactone derivative of artemisinin from Artemisia annua L., is known for its extraordinary inhibitory effects on plasmodia and trematodes and also for suppressing the proliferation of human tumor ...
Cornelia I. Ullrich, Monika von Eitzen-Ritter, Annemarie Jockel, Thomas Efferth   +3 more
doaj   +1 more source

Artesunate Inhibits the Development of Esophageal Cancer by Targeting HK1 to Reduce Glycolysis Levels in Areas With Zinc Deficiency

Frontiers in Oncology, 2022
Esophageal cancer (EC) threatens many lives in China, especially in areas with high incidences of EC. Our previous studies proved that zinc deficiency (ZD) promotes the cell cycle, thus promoting the progression of EC in areas with a high incidence of EC.
Jing Jin, Dongli Guo, Yingying Wang, Wenpeng Jiao, Daojuan Li, Yutong He   +5 more
doaj   +1 more source

Protectiveness of Artesunate Given Prior Ischemic Cerebral Infarction Is Mediated by Increased Autophagy

Frontiers in Neurology, 2018
Background: Ischemic cerebral infarction is a severe clinical condition that can cause serious mortality. Artesunate, an anti-malarial drug that is widely used in cancer treatment, is known to facilitate accelerated cell apoptosis.
Ming Shao, Yue Shen, Hongjing Sun, Delong Meng, Wei Huo, Xu Qi   +5 more
doaj   +1 more source

Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights

Advanced NanoBiomed Research, EarlyView.
This review explores how surface‐coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications, emphasizing how surface chemistry governs biocompatibility, targeting, and controlled release.
Hossein Daneshgar, Sepideh Ahmadi, Nikzad Abbariki, Navid Rabiee, Sidi A. Bencherif   +4 more
wiley   +1 more source

Pyronaridine–artesunate and artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a randomized controlled non-inferiority trial

Malaria Journal, 2018
Background Pyronaridine–artesunate is a novel artemisinin-based combination therapy. The efficacy and safety of pyronaridine–artesunate were compared with artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in ...
Johanna M. Roth, Patrick Sawa, Nicodemus Makio, George Omweri, Victor Osoti, Selpha Okach, Felix Choy, Henk D. F. H. Schallig, Pètra Mens   +8 more
doaj   +1 more source

Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants.

, 2009
Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective ...
Cairns, Matthew, Gosling, Roly, Gesase, Samwel, Mosha, Jacklin, Greenwood, Brian, Chandramohan, Daniel   +5 more
core   +1 more source

The usefulness of rapid diagnostic tests in the new context of low malaria transmission in zanzibar. [PDF]

, 2013
BACKGROUND\ud \ud We assessed if histidine-rich-protein-2 (HRP2) based rapid diagnostic test (RDT) remains an efficient tool for Plasmodium falciparum case detection among fever patients in Zanzibar and if primary health care workers continue to adhere ...
A Bhattarai, A Manjurano, A Martensson, Abdullah S. Ali, Anders Björkman, Andreas Mårtensson, Berit Aydin-Schmidt, Bryan Greenhouse, Delér Shakely, E Nicastri, G Holmgren, H Reyburn, J Baker, J Baker, J Chinkhumba, K Baltzell, KB Beshir, Kimberly A. Baltzell, Kristina Elfving, LC Okell, Lorenz von Seidlein, Max Petzold, MI Msellem, MI Veiga, ML McMorrow, ML McMorrow, MS Hsiang, Mwinyi I. Msellem, OA Koita, P Gillet, P Gillet, Rahila Omar, S Dahlstrom, S Thiam, SE Shokoples, TA Abeku, Ulrika Morris, Xu Weiping, Z Bisoffi   +38 more
core   +4 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Potential P-Glycoprotein-Mediated Drug-Drug Interactions of Antimalarial Agents in Caco-2 cells [PDF]

, 2012
Antimalarials are widely used in African and Southeast Asian countries, where they are combined with other drugs for the treatment of concurrent ailments.
Horie, Toshiharu, Oga, Enoche, Shitara, Yoshihisa, Shuichi, Sekine   +3 more
core   +1 more source

Theranostic nanoplatform for high‐performance dual‐modal magnetic resonance imaging‐guided therapy of orthotopic hepatocellular carcinoma

BMEMat, EarlyView.
This article introduces a biomimetic Mn‐doped polydopamine nanoplatform (HAMM NPs) coated with cancer cell membranes. It enables targeted hepatocellular carcinoma theranostics via T1/T2 dual‐mode magnetic resonance imaging and tumor microenvironment‐triggered sonodynamic therapy/chemodynamic therapy, achieving potent antitumor efficacy in subcutaneous ...
Jiayin Lin, Wenbo Chen, Xiuqi Hou, Kai Wang, Fan Liu, Ruling Zhang, Zhong Cao, Jian Zheng   +7 more
wiley   +1 more source