Results 61 to 70 of about 30,074 (243)

Artesunate Decreases β-Catenin Expression, Cell Proliferation and Apoptosis Resistance in the MG-63 Human Osteosarcoma Cell Line

Cellular Physiology and Biochemistry, 2017
Background: This study aims to determine the effects of artesunate on proliferation, apoptosis and β-catenin expression in the human osteosarcoma cell line MG-63.
Peng Chen, Wan-Li Gu, Ming-Zhi Gong, Jun Wang, Dong-Qing Li   +4 more
doaj   +1 more source

Rocaglates as dual-targeting agents for experimental cerebral malaria [PDF]

, 2018
Cerebral malaria (CM) is a severe and rapidly progressing complication of infection by Plasmodium parasites that is associated with high rates of mortality and morbidity.
Ayi, Kodjo, Brown, Lauren E., Cencic, Regina, Crandall, Ian, Gros, Philippe, Kain, Kevin C., Kennedy, James M., Langlais, David, Moradin, Neda, Pelletier, Jerry, Porco, John A., Schmeing, Martin, Tarry, Michael J.   +12 more
core   +1 more source

GDF15 Is Elevated in Eating Disorders and Is Involved in the Gut‐Brain Axis via Ghrelin

European Eating Disorders Review, Volume 34, Issue 1, Page 151-162, January 2026.
ABSTRACT Objective GDF15 induces anorexia and visceral discomfort, regulating appetite, food intake and potentially metabolic responses. However, its role in eating disorders remains unexplored. Method A total of 145 participants were recruited (60 patients with anorexia nervosa, 20 with bulimia nervosa, 13 with binge eating disorder, 52 participants ...
Livio Tarchi, Giulia Brancolini, Sara Giachetti, Gaia Maiolini, Emanuele Cassioli, Eleonora Rossi, Gianluca Villa, Rachele Garella, Roberta Squecco, Paolo Rovero, Paolo Comeglio, Valdo Ricca, Francesco De Logu, Romina Nassini, Giovanni Castellini   +14 more
wiley   +1 more source

Comparative study of efficacy of artesunate plus cotrimoxazole and artesunate plus chloroquine in the treatment of malaria in Nigerian children: a preliminary report [PDF]

Journal of Vector Borne Diseases, 2010
Background & objectives: The study was undertaken to evaluate the efficacy of cotrimoxazole plusartesunate and to compare the efficacy of this combination with that of artesunate plus chloroquinein the treatment of acute uncomplicated falciparum malaria ...
F.A. Fehintola, S.T. Balogun
doaj  

Hematological and biochemical effects of sub-chronic artesunate exposure in rats

Toxicology Reports, 2015
Artesunate is a potent and rapidly acting blood schizontocide used to treat chloroquine resistant malaria. Artesunate has been reported to cause embryo, reduced reproductive capacity, hepatotoxicity, neurotoxicity and hematological abnormalities ...
Papiya Bigoniya, Taranginee Sahu, Vikalp Tiwari   +2 more
doaj   +1 more source

Artesunate Alleviates Paclitaxel-Induced Neuropathic Pain in Mice by Decreasing Metabotropic Glutamate Receptor 5 Activity and Neuroinflammation in Primary Sensory Neurons

Frontiers in Molecular Neuroscience, 2022
Experimental studies on the pathogenetic process of paclitaxel-induced neuropathic pain (PINP) have been initially carried out, but PINP still has no effective therapy. Recently reported studies have highlighted the involvement of glutamate receptors and
Yize Li, Jiamin Kang, Ying Xu, Nan Li, Yang Jiao, Chenxu Wang, Chunyan Wang, Guolin Wang, Yonghao Yu, Jingjing Yuan, Linlin Zhang   +10 more
doaj   +1 more source

Artemisinin resistance in Plasmodium falciparum malaria. [PDF]

, 2009
BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
An, Sen Sam, Ariey, Frederic, Chotivanich, Kesinee, Das, Debashish, Day, Nicholas PJ, Dondorp, Arjen M, Hanpithakpong, Warunee, Herdman, Trent, Imwong, Mallika, Lee, Sue J, Lim, Pharath, Lindegardh, Niklas, Lwin, Khin Maung, Nosten, François, Phyo, Aung Phae, Ringwald, Pascal, Silamut, Kamolrat, Singhasivanon, Pratap, Socheat, Duong, Tarning, Joel, White, Nicholas J, Yeung, Shunmay, Yi, Poravuth   +22 more
core   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India

Malaria Journal, 2020
Background Parenteral artesunate is the treatment of choice for severe malaria. It is safe, efficacious and well tolerated anti-malarial. However, delayed haemolysis has been reported in travellers, non-immune individuals and in African children. Methods
Deepali Savargaonkar, Manoj Kumar Das, Amar Verma, Jeevan K. Mitra, C. P. Yadav, Bina Srivastava, Anupkumar R. Anvikar, Neena Valecha   +7 more
doaj   +1 more source

Declining Burden of Plasmodium vivax in a Population in Northwestern Thailand from 1995 to 2016 before Comprehensive Primaquine Prescription for Radical Cure. [PDF]

, 2020
All Plasmodium cases have declined over the last decade in northwestern Thailand along the Myanmar border. During this time, Plasmodium vivax has replaced Plasmodium falciparum as the dominant species. The decline in P.
Carrara, Verena I, Charunwatthana, Prakaykaew, Chu, Cindy S, McGready, Rose, Nosten, François, Parker, Daniel M, Proux, Stéphane   +6 more
core