Results 61 to 70 of about 14,154 (238)

Value of 2‐Dimensional Shear‐Wave Elastography in Assessing Tibial Nerve Stiffness in Diabetic Peripheral Neuropathy

Journal of Ultrasound in Medicine, EarlyView.
Objectives The morphological alterations of the tibial nerve in patients with diabetes mellitus, both with and without diabetic peripheral neuropathy (DPN), are challenging to differentiate using B‐mode ultrasound. In this study, we assessed the stiffness changes of the tibial nerve by 2‐dimensional shear‐wave elastography (2D‐SWE). Methods We gathered
Jiafan Li, Shaozhi Cai, Yuxia Zhai, Ruoting Zheng, Junbin Du   +4 more
wiley   +1 more source

Effect of Plectranthus Amboinicus Extract on BUN and Creatinine Levels and Cellular Response Proinflammatory Factors TNF-α and IL-1β on Gout Arthritis Patients [PDF]

, 2014
The purpose of this research was to develop anti-cytokine-based treatment using extract of Plectranthus amboinicus applied to gout arthritis (GA) patients. The research was quasi experimental, with a pretest-posttest randomized control group design.
Martini, S. (Santi), Muniroh, L. (Lailatul), Nindya, T. S. (Triska), Solfaine, R. (Rondius)   +3 more
core   +2 more sources

Long‐term remission in gout: Challenges and future opportunities

Rheumatology &Autoimmunity, EarlyView.
Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley   +1 more source

TREM‐1 Blockade Inhibits Inflammasome Activation and Pyroptosis: Novel Insights on the Role of TREM‐1 and Syk in Monosodium Urate Crystal‐Induced Inflammation

Immunology, EarlyView.
Schematic overview of the roles triggering receptor expressed on myeloid cells‐1 (TREM‐1) plays in monosodium urate (MSU) crystal‐induced inflammasome activation and IL‐1β secretion in gout arthritis. The present study provides novel data suggesting that blockade of TREM‐1 by LP17 attenuates MSU‐crystal‐induced inflammation through inhibition of ...
Yair Molad, Irina Lagovsky, Vitaly Kliminski   +2 more
wiley   +1 more source

Suppressing chondrocyte cuproptosis by syringaresinol-4-O-β-d-glucoside alleviates gouty arthritis

Frontiers in Pharmacology
BackgroundGouty arthritis is a rheumatic disease characterized by synovial inflammation and cartilage damage. Current therapeutic options for gouty arthritis, such as colchicine, primarily relieve the symptoms, which makes treatment challenging.MethodsWe
Shaotian Fu, Han Du, Xiao Ling, Hanyi Wang, Jianan Chen, Hang Zhang, Wugui Chen, Chengzhao Liu, Hailong Ma, Chengshou Lin, Peixiang Ma, An Qin   +11 more
doaj   +1 more source

Association of glucagon‐like peptide‐1 receptor agonist use with clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
This TriNetX (US, 2016–2023) study compared clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes treated with GLP‐1 receptor agonists vs DPP4 inhibitors. ABSTRACT Objectives To evaluate whether glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are associated with improved survival and renal outcomes in patients with ...
Yu‐Ting Yu, Ying Chun Lee, Yu‐Wei Fang, Wen‐Hui Hsieh, Ming‐Hsien Tsai   +4 more
wiley   +1 more source

Hubungan Status Gizi Dengan Gout Arthritis Pada Lanjut Usia Di Puskesmas Wawonasa Manado [PDF]

, 2015
:Gout Arthritis is a disease that occurs due to a chronic increase in uric acid concentration I in plasma. Gout is a buildup of uric acid in the body and abnormalities in purine metabolism.
Bidjuni, H. (Hendro), Hamel, R. (Rivelino), Lumunon, O. J. (Oktavina)   +2 more
core  

Mid‐Term Tibial Tunnel Enlargement and Graft Maturation After ACL Reconstruction: A 5‐Year Follow‐Up Linking Morphological Dynamics to Knee Function

Orthopaedic Surgery, EarlyView.
Tibial tunnel diameter increased within 2 years after single‐bundle ACL reconstruction, then slightly decreased by 5 years but remained above baseline. Moderate site‐specific correlations were observed between tunnel enlargement at the tibial tunnel exit, graft maturation at 2 years, and anterior stability at 5 years without long‐term functional ...
Wenbo Tang, Feng Gao, Tao Li, Xiaohan Zhang, Bingying Zhang, Jingyi Sun, Feng Qu, Mingze Liu, Jingbin Zhou   +8 more
wiley   +1 more source

Biomimetic Integrated Nanozyme for Flare and Recurrence of Gouty Arthritis

Asian Journal of Pharmaceutical Sciences
Flare and multiple recurrences pose significant challenges in gouty arthritis. Traditional treatments provide temporary relief from inflammation but fail to promptly alleviate patient pain or effectively prevent subsequent recurrences.
Rui Wang, Tongyao Liu, Xinhong Li, Enhao Lu, Yiting Chen, Kuankuan Luo, Tao Wang, Xueli Huang, Zhiwen Zhang, Shilin Du, Xianyi Sha   +10 more
doaj   +1 more source

Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout. [PDF]

, 2019
ObjectiveLesinurad (LESU) is a selective urate reabsorption inhibitor approved at 200 mg daily for use with a xanthine oxidase inhibitor (XOI) to treat hyperuricaemia in gout patients failing to achieve target serum urate on XOI. The aim of the study was
Baumgartner, Scott, Goldfarb, David S, Jalal, Diana, Pillinger, Michael, Saag, Kenneth G, Schechter, Bruce M, Terkeltaub, Robert, Valiyil, Ritu, White, William B   +8 more
core   +1 more source