Results 21 to 30 of about 41,853 (158)

Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms [PDF]

, 2020
The phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its orally bioavailable prodrug, methyl-Varespladib (LY333013) inhibit PLA2 activity of a wide variety of snake venoms.
Bruno Lomonte, Williams, David J., Lewin, Matthew R., Matthew R. Lewin, José María Gutiérrez, Lomonte, Bruno, Gutiérrez, José María, David. J. Williams   +7 more
core   +1 more source

Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors [PDF]

, 2013
Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects
Wunder, C., Peigneur, S., Silke Kauferstein, Melaun, Christian, Annette Nicke, Nicke, Annette, Dietrich Mebs, Christian Melaun, Peigneur, Steve, Kauferstein, S., Kauferstein, Silke, Wunder, Cora, Kendel, Y., Mebs, D., Kurz, A., Steve Peigneur, Tytgat, Jan, Melaun, C., Kendel, Yvonne, Kurz, Alexander, Mebs, Dietrich, Yvonne Kendel, Jan Tytgat, Cora Wunder, Alexander Kurz, Nicke, A., Tytgat, J.   +26 more
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Bothrops atrox and Bothrops lanceolatus Venoms In Vitro Investigation: Composition, Procoagulant Effects, Co-Factor Dependency, and Correction Using Antivenoms

, 2023
Bothrops venoms are rich in enzymes acting on platelets and coagulation. This action is dependent on two major co-factors, i.e., calcium and phospholipids, while antivenoms variably neutralize venom-related coagulopathy effects.
Rabah Gahoual, Anne-Laure Dupart, Sébastien Larréché, Virginie Siguret, Georges Jourdi, Pascale Gaussem, Jean-Philippe Chippaux, Aurore Bousquet, Christilla Bachelot-Loza, Lucie Chevillard, Bruno Mégarbane   +10 more
core   +1 more source

Suramin inhibits the early effects of PLA(2) neurotoxins at mouse neuromuscular junctions: a twitch tension study [PDF]

, 2011
Several phospholipase A(2) (PLA(2)) neurotoxins from snake venoms can affect acetylcholine release at the neuromuscular junction. In isolated nerve-muscle preparations three distinct phases have been described for this phenomenon: An initial transient ...
Fathi, Behrooz, Rowan, Edward G, Harvey, Alan L   +2 more
core   +3 more sources

Differences between Two Groups of Burmese Vipers (Viperidae: Azemiops) in the Proteomic Profiles, Immunoreactivity and Biochemical Functions of Their Venoms

, 2022
Two recently revised Azemiops snakes with apparent differences in their external appearances and skeletal morphologies but unclear genetic boundaries have been proposed. Some researchers have refrained from using the newly proposed taxonomy because these
Gao, Jian-Fang, Zhao, Hong-Yan, Wen, Lin, Hong-Yan Zhao, Jian-Fang Gao, Zheng, Si-Rui, Lin Wen, Ji, Xiang, Yan Sun, Sun, Yan, Si-Rui Zheng, Xiang Ji   +11 more
core   +1 more source

Venom of the giant ant Dinoponera quadriceps attenuates inflammatory pain in mouse cutaneous wound healing model

Acta Scientiarum: Biological Sciences, 2020
Arthropod venoms are potential sources of bioactive substances, providing tools for the validation of popular use and new drugs design. Ants belonging to the genus Dinoponera are used in the folk medicine to treat inflammatory conditions.
Ana Maria Sampaio Assreuy, Beatriz Lima Adjafre, Évilla Rayanne Oliveira Sousa, Ana Paula Negreiros Nunes Alves, Alana de Freitas Pires, Yves Quinet, Mário Rogério Lima Mota   +6 more
doaj   +1 more source

Epidemiological aspects of centipede (Scolopendromorphae: Chilopoda) bites registered in Greater S. Paulo, SP, Brazil Aspectos epidemiológicos de acidentes de lacraias (Scolopendromorphae: Chilopoda) em região urbana de São Paulo, Brasil

Revista de Saúde Pública, 1998
INTRODUCTION: The lack of basic knowledge on venomous arthropods and the benignity of the clinical manifestations contribute to the centipede bite victims' not being taken to a treatment reference center, leading to underestimation of the number of cases
Irene Knysak, Rosana Martins, Carlos R. Bertim   +2 more
doaj   +1 more source

Screening Snake Venoms for Toxicity to Tetrahymena Pyriformis Revealed Anti-Protozoan Activity of Cobra Cytotoxins

, 2020
Snake venoms possess lethal activities against different organisms, ranging from bacteria to higher vertebrates. Several venoms were shown to be active against protozoa, however, data about the anti-protozoan activity of cobra and viper venoms are very ...
Vladislav Starkov, Elena Kruykova, Victor Tsetlin, Elena Cheremnykh, Olga Kuleshina, Yuri Utkin, Alexey Osipov, Leonid Kozlov, Rustam Ziganshin, Tatyana Andreeva   +9 more
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AaeAP1 and AaeAP2: Novel Antimicrobial Peptides from the Venom of the Scorpion, Androctonus aeneas: Structural Characterisation, Molecular Cloning of Biosynthetic Precursor-Encoding cDNAs and Engineering of Analogues with Enhanced Antimicrobial and Anticancer Activities

Toxins, 2015
The main functions of the abundant polypeptide toxins present in scorpion venoms are the debilitation of arthropod prey or defence against predators.
Qiang Du, Xiaojuan Hou, Lei Wang, Yingqi Zhang, Xinping Xi, Hui Wang, Mei Zhou, Jinao Duan, Minjie Wei, Tianbao Chen, Chris Shaw   +10 more
doaj   +1 more source

Snake C-Type Lectins Potentially Contribute to the Prey Immobilization in Protobothrops mucrosquamatus and Trimeresurus stejnegeri Venoms

, 2020
Snake venoms contain components selected to immobilize prey. The venoms from Elapidae mainly contain neurotoxins, which are critical for rapid prey paralysis, while the venoms from Viperidae and Colubridae may contain fewer neurotoxins but are likely to ...
Hao Li, James Mwangi, Qiumin Lu, Chengbo Long, Chuanbin Shen, Ming Liu, Jiameng Li, Ren Lai, Huiwen Tian, Runjia Xu   +9 more
core   +1 more source