Results 11 to 20 of about 457,350 (333)

Mesenchymal Stem Cells for Treating Articular Cartilage Defects and Osteoarthritis

Cell Transplantation, 2015
Articular cartilage damage and osteoarthritis are the most common joint diseases. Joints are prone to damage caused by sports injuries or aging, and such damage regularly progresses to more serious joint disorders, including osteoarthritis, which is a ...
Yu Wang, Mei Yuan, Quan-Yi Guo, Shi-Bi Lu, Jiang Peng   +4 more
doaj   +2 more sources

Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect

Nature Communications, 2023
Induced pluripotent stem cells (iPSCs) are a promising resource for allogeneic cartilage transplantation to treat articular cartilage defects that do not heal spontaneously and often progress to debilitating conditions, such as osteoarthritis.
Kengo Abe, A. Yamashita, Miho Morioka, N. Horike, Yoshiaki Takei, Saeko Koyamatsu, K. Okita, Shuichi Matsuda, N. Tsumaki   +8 more
semanticscholar   +1 more source

SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Cartilage is essential in vertebrate development and adulthood. Cartilage growth plates ensure skeletal growth until closing at puberty, and articular cartilage ensures lifelong structural and functional integrity of joints.
A. Haseeb, R. Kc, M. Angelozzi, Charles de Charleroy, Danielle Rux, R. Tower, L. Yao, Renata Pellegrino da Silva, M. Pacifici, L. Qin, V. Lefebvre   +10 more
semanticscholar   +1 more source

Strategies for Articular Cartilage Repair and Regeneration

Frontiers in Bioengineering and Biotechnology, 2021
Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis.
Yanxi Liu, Karan M. Shah, Jian Luo
semanticscholar   +1 more source

Ultrafast, tough, and adhesive hydrogel based on hybrid photocrosslinking for articular cartilage repair in water-filled arthroscopy

Science Advances, 2021
A photocrosslinking hydrogel technique facilitates articular cartilage repair in minimally invasive surgery.
Yujie Hua, Huitang Xia, Litao Jia, Jinzhong Zhao, Dandan Zhao, Xiaoyu Yan, Yiqing Zhang, Shengjian Tang, Guangdong Zhou, Linyong Zhu, Qiuning Lin   +10 more
semanticscholar   +1 more source

Mechanical stress determines the configuration of TGFβ activation in articular cartilage

Nature Communications, 2021
Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered the development of disease-modifying therapy. The functional relationship between subchondral bone (SB) and articular cartilage (AC) is unclear.
G. Zhen, Qiaoyue Guo, YuSheng Li, Chuanlong Wu, Shouan Zhu, Ruomei Wang, X. Guo, Byoung Choul Kim, Jessie Huang, Y. Hu, Yang Dan, M. Wan, T. Ha, S. An, Xu Cao   +14 more
semanticscholar   +1 more source

Main and Minor Types of Collagens in the Articular Cartilage: The Role of Collagens in Repair Tissue Evaluation in Chondral Defects

International Journal of Molecular Sciences, 2021
Several collagen subtypes have been identified in hyaline articular cartilage. The main and most abundant collagens are type II, IX and XI collagens.
Lourdes Alcaide-Ruggiero, V. Molina-Hernández, M. Granados, J. M. Domínguez   +3 more
semanticscholar   +1 more source

Clinical Application Status of Articular Cartilage Regeneration Techniques: Tissue-Engineered Cartilage Brings New Hope

Stem Cells International, 2020
Hyaline articular cartilage lacks blood vessels, lymphatics, and nerves and is characterised by limited self-repair ability following injury. Traditional techniques of articular cartilage repair and regeneration all have certain limitations.
Shuangpeng Jiang, Weimin Guo, Guangzhao Tian, Xujiang Luo, Liqing Peng, Shuyun Liu, X. Sui, Q. Guo, Xu Li   +8 more
semanticscholar   +1 more source

FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Osteoarthritis (OA) is the most prevalent joint disease and has reached epidemic proportions in the United States. Currently, there are no effective therapeutic approaches to treat OA. Thus, there is an urgent need to develop mechanistically-
Cuicui Wang, Jie Shen, J. Ying, Ding Xiao, R. O’Keefe   +4 more
semanticscholar   +1 more source

Enhanced Tissue Integration During Cartilage RepairIn VitroCan Be Achieved by Inhibiting Chondrocyte Death at the Wound Edge [PDF]

, 2009
Objective: Experimental wounding of articular cartilage results in cell death at the lesion edge. The objective of this study was to investigate whether inhibition of this cell death results in enhanced integrative cartilage repair.
Archer, Charles W., Burdon, Drew, Duance, Victor C., Gilbert, Sophie J., Gonzalez, Lee G., Khan, Ilyas M., Singhrao, Simarjit Kaur, Thomson, Brian M.   +7 more
core   +1 more source