Human stem cells and articular cartilage regeneration. [PDF]
, 2012 The regeneration of articular cartilage damaged due to trauma and posttraumatic osteoarthritis is an unmet medical need. Current approaches to regeneration and tissue engineering of articular cartilage include the use of chondrocytes, stem cells ...
Inui, Atsuyuki +2 more
core +4 more sources
Study on the damage mechanism of articular cartilage based on the fluid–solid coupled particle model
Advances in Mechanical Engineering, 2015 Articular cartilage damage is the primary cause of osteoarthritis. Very little literature work focuses on the microstructural damage mechanism of articular cartilage.
Jun Hong, T Matthew Evans, Peter L Mente
doaj +1 more source
Journal of Orthopaedic Surgery and Research, 2008 Introduction The collagen structure in the superficial zone of articular cartilage is critical to the tissue's durability. Early osteoarthritis is often characterized with fissures on the articular surface.
Zheng Ming H, Kirk Thomas B, Wu Jian P
doaj +1 more source
Scientific Reports, 2021 Articular cartilage is built by chondrocytes which become less active with age. This declining function of the chondrocytes, together with the avascular nature of the cartilage, impedes the spontaneous healing of chondral injuries.
Alexandre Dufour +10 more
doaj +1 more source
Physiological incongruity of the humero-ulnar joint [PDF]
, 1993 Investigations into the distribution of subchondral bone density in the human elbow have suggested that the geometry of the trochlear notch deviates from a perfect fit with the trochlea, and that the load is transmitted ventrally and dorsally rather than
Eckstein, Felix +5 more
core +1 more source
Application of an acoustofluidic perfusion bioreactor for cartilage tissue engineering [PDF]
, 2014 Cartilage grafts generated using conventional static tissue engineering strategies are characterised by low cell viability, suboptimal hyaline cartilage formation and, critically, inferior mechanical competency, which limit their application for ...
Li, Siwei +7 more
core +6 more sources
Regulation of growth plate and articular chondrocyte differentiation : implications for longitudinal bone growth and articular cartilage formation [PDF]
, 2014 Overall height and body proportions in humans are determined primarily by bone growth. Linear bone growth occurs at the growth plate, a thin layer of cartilage at the ends of long bones between the epiphysis and metaphysis.
Chau, Michael
core +1 more source
Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9 [PDF]
, 2007 Objective. Human osteoarthritis (OA) is characterized by a pathologic shift in articular cartilage homeostasis toward the progressive loss of extracellular matrix (ECM).
Cucchiarini, Magali +5 more
core +2 more sources
Differential gene expression associated with postnatal equine articular cartilage maturation
BMC Musculoskeletal Disorders, 2008 Background Articular cartilage undergoes an important maturation process from neonate to adult that is reflected by alterations in matrix protein organization and increased heterogeneity of chondrocyte morphology.
Stromberg Arnold J +3 more
doaj +1 more source
Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures [PDF]
, 2013 The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise.
Blitterswijk, C.A. van +4 more
core +3 more sources