Dose-Dependent Effects of Heat Shock Cognate 70 on Viability and Apoptosis-Related Gene Expression in In Vitro-Produced Bovine Embryos. [PDF]
Vet SciGarza-Arredondo AJ +7 more
europepmc +1 more source
An Update on Viral Conjunctivitis Treatment Strategies: A Narrative Literature Review. [PDF]
MicroorganismsShunmugam M +3 more
europepmc +1 more source
Beyond Cultures: The Evolving Role of Molecular Diagnostics, Synovial Biomarkers and Artificial Intelligence in the Diagnosis of Prosthetic Joint Infections. [PDF]
J Clin MedMaritati M +7 more
europepmc +1 more source
Antiviral Research, 2016 Artificial ribonucleases (aRNases) are small compounds catalysing RNA cleavage. Recently we demonstrated that aRNases readily inactivate various viruses in vitro. Here, for three series of aRNases (1,4-diazabicyclo [2.2.2]octane-based and peptide-like compounds) we show that apart from ribonuclease activity the aRNases display chaotropic-like and ...
Lyudmila S Koroleva +2 more
exaly +5 more sources
An Artificial Imine Reductase based on the Ribonuclease S Scaffold
ChemCatChem, 2014 AbstractDative anchoring of a piano‐stool complex within ribonuclease S resulted in an artificial imine reductase. The catalytic performance was modulated upon variation of the coordinating amino acid residues in the S‐peptide. Binding of Cp*Ir (Cp*=C5Me5) to the native active site resulted in good conversions and moderate enantiomeric excess values ...
Valentin Kohler +2 more
exaly +3 more sources
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A METHOD FOR SYNTHESIS OF AN ARTIFICIAL RIBONUCLEASE
Nucleosides, Nucleotides and Nucleic Acids, 20015-Amino-2,9-dimethyl-1,10-phenanthroline-oligonucleotide conjugates have been synthesized. A 2'-O-methyl octaribonucleotide carrying a 2'-aminoethoxymethyl linker in a central position was produced. Reaction of the aminoneocuproine phenyl carbamate with the fully deprotected oligonucleotide in aqueous solution gave virtually quantitative conversion ...
Roger Strömberg
exaly +3 more sources
ChemInform Abstract: A Method for Synthesis of an Artificial Ribonuclease
ChemInform, 2001 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hans Aastroem, Roger Stroemberg
openaire +2 more sources
SYNTHESIS AND CHARACTERIZATION OF POLYAMINE-BASED BIOMIMETIC CATALYSTS AS ARTIFICIAL RIBONUCLEASE
Nucleosides, Nucleotides and Nucleic Acids, 2001Several polyamine derivatives (I-V) conjugated with or without an intercalative moiety were prepared as ribonuclease mimics. Although no DNA-cleaving activity was observed for all compounds tested, mimics I, III, and V bearing an intercalative moiety along with the primary amine and/or imidazole moieties exhibited potent RNA-cleaving activity at near ...
Hiroaki Sawai, K Shinozuka
exaly +3 more sources
Characterization of an artificial dimer of ribonuclease H using 1H NMR spectroscopy
Journal of Biomolecular NMR, 1996The protein fusion technique was applied in the synthesis of an artificial dimer of ribonuclease H (305 residues). 1H NMR spectroscopy was used to analyze the structure of this dimer. Spectral profiles and pKa values of the histidine residues obtained using 1H NMR indicate that the dimer retains the secondary and tertiary structures of the intact ...
Daiwen Yang +2 more
exaly +3 more sources