Results 181 to 190 of about 7,439 (222)
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Org. Biomol. Chem., 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Teija, Niittymäki, Harri, Lönnberg
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Teija, Niittymäki, Harri, Lönnberg
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Combinatorial Library of Artificial Ribonucleases
Nucleosides and Nucleotides, 1999Abstract Conjugates of lanthanide complexes and oligonucleotides have been shown to bind and to cleave complementary RNA. Modified oligonucleotide building blocks are required to ensure stability of the oligonucleotide against cellular nucleases. For an efficient cleavage, an accessible site on the structured mRNA is required. For the identification of
Dieter Hüsken +3 more
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Synthesis and Characterization of Artificial Ribonucleases
Nucleosides and Nucleotides, 1999Abstract RNA cleaving molecules were synthesized by conjugating components of ribonucleases A and T1 catalytic centers (imidazole, aliphatic amino and/or carboxy residues) to intercalating and cationic structures. The artificial ribonucleases were shown cleave RNA at Py-Pu sites in single-stranded regions.
N. S. Zhdan +6 more
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Design and Synthesis of Metal-Free Artificial Ribonucleases
Protein & Peptide Letters, 2007The present review is aimed at giving a general overview of our results in the field of designing and synthesizing simple peptide-like molecules that mimic structural and functional aspects of natural ribonucleases, as well as designing oligonucleotide-based artificial ribonucleases.
Ludmila S, Koroleva +3 more
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Molecular Design of Artificial Ribonucleases Using Electrostatic Interaction
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Ekaterina A, Burakova +1 more
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The Sequence-Specific Cleavage of RNA by Artificial Chemical Ribonucleases
Antisense and Nucleic Acid Drug Development, 1997Based on work spanning 50 years, several groups have recently achieved the specific cleavage of RNA by attaching RNA-cleaving chemical moieties to antisense oligonucleotides. Such artificial chemical ribonucleases have potential as a possible next generation of antisense compounds and also as probes for structural and functional investigations of RNA ...
R, Häner, J, Hall
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Journal of Inorganic Biochemistry, 2022
Artificial ribonucleases, also known as synthetic ribozymes, were synthesized with an internal, stereochemically-pure, abasic threoninol backbone-residue to which the RNA transesterification catalyst copper (II) terpyridine was covalently linked.
William C, Putnam, James K, Bashkin
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Artificial ribonucleases, also known as synthetic ribozymes, were synthesized with an internal, stereochemically-pure, abasic threoninol backbone-residue to which the RNA transesterification catalyst copper (II) terpyridine was covalently linked.
William C, Putnam, James K, Bashkin
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SPEED LIMITS FOR ARTIFICIAL RIBONUCLEASES
Comments on Inorganic Chemistry, 2008There are four major catalytic roles for natural and artificial nucleases that catalyze the hydrolytic cleavage of RNA. For metal ion complexes that act as artificial nucleases, the most important role is the stabilization of the phosphorane-like transition state.
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An RNA sequence determines the speed of its cleavage by artificial ribonucleases
Russian Journal of Bioorganic Chemistry, 2010Phosphodiester bonds in RNA situated between similar nucleotides but in different sequences (context) were split under the action of artificial and natural ribonucleases with different speeds, and the reason for this phenomenon has not yet been fully revealed.
N V, Tamkovich +3 more
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Allosterically Controlled Ribozymes as Artificial Ribonucleases
2004Ribozymes are catalytic RNAs. Representative ribozymes that exist in nature include hammerhead, hairpin, hepatitis delta virus (HDV) and Neurospora VS ribozymes; group I and II introns; the RNA subunit of RNase P; and ribosomal RNA (Birikh et al. 1997; Doudna 1998; Zhou and Taira 1998; Walter and Burke 1998; Carola and Eckstein 1999; Gesteland et al ...
M. Iyo +3 more
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