Results 211 to 220 of about 538,570 (408)

Rapid and Noninvasive Early Detection of Lung Cancer by Integration of Machine Learning and Salivary Metabolic Fingerprints Using MS LOC Platform: A Large‐Scale Multicenter Study

open access: yesAdvanced Science, EarlyView.
Salivary metabolic signatures associated with lung cancer are systematically characterized through a self‐developed high‐throughput mass spectrometry Lab‐on‐a‐Chip platform. Utilizing these metabolic fingerprints, SalivaMLD, an integrated machine‐learning‐driven classification model is developed and demonstrates superior performance in detecting lung ...
Shuang Lin   +17 more
wiley   +1 more source

A General Strategy for C(sp3)─H Bond Etherification via Quinoline Derivative‐Mediated Electrolysis

open access: yesAdvanced Science, EarlyView.
A quinoline‐based mediator is introduced for the electrochemical etherification of C(sp3)─H bonds, enabling the process with minimal dependence on substrate electronic properties. The reaction demonstrates compatibility with various C─H bonds, including tertiary benzylic C─H bonds and unactivated C(sp3)─H bonds.
Yousen Xu   +4 more
wiley   +1 more source

Catalyst‐Free Direct Hydrocarbonation of Terminal Alkynes Toward E‐Alkene Substituted Stabilized Sulfoxonium Ylides

open access: yesAdvanced Science, EarlyView.
The authors introduce a high‐throughput synthesis using amide‐sulfoxonium ylides as new nucleophilic reagents, enabling a catalyst‐ and base‐free hydrocarbonation of terminal alkynes under mild conditions, resulting in various E‐alkene substituted (hetero)amide‐sulfoxonium ylides with excellent regio‐ and stereoselectivity. The late‐stage modifications
Haiting Wu   +6 more
wiley   +1 more source

Asymmetric paired oxidative and reductive catalysis enables enantioselective alkylarylation of olefins with C(sp3)−H bonds

open access: yesNature Communications
Enantioselective transformations of hydrocarbons to three-dimensional chiral molecules remain a significant challenge in synthetic chemistry.
Long Zou   +3 more
doaj   +1 more source

Lysozyme-catalysed hydrolysis of some β-aryl di-N-acetylchitobiosides [PDF]

open access: green, 1967
Gordon Lowe   +3 more
openalex   +1 more source

Aryl hydrocarbon receptor and intestinal immunity

open access: yesMucosal Immunology, 2018
B. Lamas, J. Natividad, H. Sokol
semanticscholar   +1 more source

Palladium‐Catalyzed Dual Csp2─Csp3 Bond Formation: A Versatile Platform for the Synthesis of Benzo‐Fused Heterocycles

open access: yesAdvanced Science, EarlyView.
Pd(II)/Cu(I) co‐catalyzed dual Csp2─Csp3 bonds construction from unactivated alkenes and arylsulfonyl chlorides to access benzo‐fused heterocycles with high efficiency and chemoselectivity. Abstract Transition‐metal‐catalyzed transformations offer a powerful approach to rapidly synthesize complex benzo‐fused heterocycles, crucial for drug and material ...
Jiahui Huang   +9 more
wiley   +1 more source

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