Results 111 to 120 of about 36,412 (300)
Environmental Ligands of the Aryl Hydrocarbon Receptor and Their Effects in Models of Adult Liver Progenitor Cells [PDF]
Jan Vondráček, Miroslav Machala
openalex +1 more source
Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam +12 more
wiley +1 more source
Prioritising research on endocrine disruption in the marine environment: a global perspective
ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto +23 more
wiley +1 more source
Expression analysis of aryl hydrocarbon receptor repressor (AHRR) gene in gallbladder cancer
Puneet Kumar +7 more
openalex +1 more source
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou +6 more
wiley +1 more source
Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera +5 more
wiley +1 more source

