Results 121 to 130 of about 1,983,941 (246)

The role of Aryl Hydrocarbon Receptor (AhR) signaling pathway in oral squamous cell carcinoma (OSCC): preliminary results. [PDF]

, 2018
OBJECTIVES: A large number of experimental and clinical studies suggest that the origin of oral squamous cell carcinoma (OSCC) is linked to environmental carcinogenesis (tobacco, alcohol).
Xu, Cui, Ferreira, Leticia, Ramos-Junior, Erivan, Morandini, Ana Carolina, Lee, Renee   +4 more
core  

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

The potential of aryl hydrocarbon receptor as receptors for metabolic changes in tumors

Frontiers in Oncology
Cancer cells can alter their metabolism to meet energy and molecular requirements due to unfavorable environments with oxygen and nutritional deficiencies. Therefore, metabolic reprogramming is common in a tumor microenvironment (TME).
Zhiying Wang, Yuanqi Zhang, Zhihong Liao, Mingzhang Huang, Xiaorong Shui   +4 more
doaj   +1 more source

Aryl-hydrocarbon receptor binding and the incidence of type 2 diabetes : the brazilian longitudinal study of adult health (ELSABrasil) [PDF]

, 2020
Persistent organic pollutants (POPs) may cause diabetes, in part through aryl hydrocarbon receptor (AhR) binding. Ensuing mitochondrial dysfunction is postulated to mediate this effect. We aim to investigate the association of POPs with incident diabetes
Bracco, Paula Andreghetto, Castilhos, Cristina D., Youngmi, Kim Pak, Sora, Kang, Hong, Kyu Lee, Suyeol, Im, Duncan, Bruce Bartholow, Schmidt, Maria Inês, Vigo, Álvaro   +8 more
core  

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production

, 2014
The aryl hydrocarbon receptor (AHR) binds to environmental toxicants including synthetic halogenated aromatic hydrocarbons and is involved in a diverse array of biological processes.
Schlezinger, J, Lowe, MM, Patel, G, McCune, Joseph, Louie, A, Franks, DG, Mold, JE, Kanwar, B, Huang, Y, Pollastri, MP, Wang, C   +10 more
core  

The aryl hydrocarbon receptor in inflammatory bowel disease: linking the environment to disease pathogenesis

, 2012
The aryl hydrocarbon receptor (AhR), a transcription factor activated by a large number of environmental agents, modulates the activity of immune and nonimmune cells in the gut, and may represent an important link between the environment and the immune ...
PALLONE, FRANCESCO, Monteleone, I, MONTELEONE, GIOVANNI, Macdonald, T, Monteleone, G, MONTELEONE, IVAN, Pallone, F   +6 more
core   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Refining Genetic Instruments for Dietary Intake Mendelian Randomization Using Phenome‐Wide Association Studies

Genetic Epidemiology, Volume 50, Issue 8, December 2026.
ABSTRACT Most Mendelian randomization (MR) of dietary intake use the full set of genome‐wide significant (GWS) variants in the instrumental variable (IV), likely biasing causal estimates due to pleiotropy. To characterize the common methods to handle pleiotropy in dietary intake MR, we conducted a scoping review of the literature on dietary intake MR ...
Kristen J. Sutton, Julie E. Gervis, Moomal Jatoi, Liang‐Dar Hwang, Audrey E. Hendricks, Debashis Ghosh, Kenneth E. Westerman, Joanne B. Cole   +7 more
wiley   +1 more source

Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy. [PDF]

J Immunother Cancer, 2023
Kober C, Roewe J, Schmees N, Roese L, Roehn U, Bader B, Stoeckigt D, Prinz F, Gorjánácz M, Roider HG, Olesch C, Leder G, Irlbacher H, Lesche R, Lefranc J, Oezcan-Wahlbrink M, Batra AS, Elmadany N, Carretero R, Sahm K, Oezen I, Cichon F, Baumann D, Sadik A, Opitz CA, Weinmann H, Hartung IV, Kreft B, Offringa R, Platten M, Gutcher I.   +30 more
europepmc   +1 more source