Results 141 to 150 of about 1,983,941 (246)

Aryl hydrocarbon receptor and mitochondrial homeostasis: from CYP1A1-dependent ROS to mitophagy

Frontiers in Cell Death
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor originally characterized as a xenosensor that mediates cellular responses to environmental pollutants, including polycyclic aromatic hydrocarbons.
Guillermo Elizondo
doaj   +1 more source

Reframing the Gut–Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases

Annals of Neurology, Volume 100, Issue 5, Page 915-930, November 2026.
Gut wall physiology in multiple sclerosis (MS) and autoimmune neurologic diseases remains underexplored but may span gut barrier dysfunction, enteric glial targeting, mucosal immune dysregulation, and autoimmune targets within the enteric nervous system (ENS).
Federico Montini, Sean J. Pittock, Laura Cacciaguerra, Howard L. Weiner, Luke A. Schwerdtfeger   +4 more
wiley   +1 more source

The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases? [PDF]

Int J Mol Sci, 2022
Shivanna B, Chu C, Moorthy B.
europepmc   +1 more source

Conditional expression of a constitutively active aryl hydrocarbon receptor in MCF-7 human breast cancer cells

, 2002
In addition to inducing transcription of a battery of target genes encoding drug-metabolizing enzymes, the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to induce antiestrogenic responses.
Hassepass, I, McGuire, J, Walter, Bock K, Köhle, C, Bock-Hennig, BS, Poellinger, L,   +5 more
core   +1 more source

Aryl hydrocarbon receptor (AHR) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1368-1378, November 2026.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

The landscape of biased agonism in aryl hydrocarbon receptor signaling: current clues and future directions

Frontiers in Pharmacology
Our understanding of the aryl hydrocarbon receptor (AhR) signaling pathway has significantly advanced since its initial discovery, revealing roles in both toxicology and normal physiological processes like immunity and organ development.
Zdeněk Dvořák, Jakub Přikryl
doaj   +1 more source

A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors

, 2002
Published online before print July 9, 2002The dioxin/aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor regulating transcription of a battery of genes encoding xenobiotic metabolizing enzymes.
Gradin, K., Pettersson, S., Annika Hanberg, Whitelaw, M., Poellinger, L., Sven Pettersson, Lorenz Poellinger, Patrik Andersson, Hanberg, A., Rubio, C., Katarina Gradin, Andersson, P., Jacqueline McGuire, Murray L. Whitelaw, Carlos Rubio, McGuire, J., McGuire, J, Whitelaw, ML, Poellinger, L,, Hanberg, A, Andersson, P, Rubio, C,, Gradin, K, Pettersson, S,   +23 more
core   +1 more source

Aryl hydrocarbon receptor (AHR) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

The microbiome and brain metastasis in non‐small cell lung cancer: A graded appraisal and a framework for prevention‐oriented research

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This Review proposes a microbiome–premetastatic brain niche axis connecting gut, lung, and intratumoral microbes with metabolites, blood–brain barrier remodeling, neuroimmune priming, and brain metastasis in NSCLC. It integrates current evidence while distinguishing established mechanisms from associations and hypotheses requiring prospective and ...
Long Liang, Fangjuan Hu, Xiaofeng Wang, Chunhan Tang, Chun Wang, Gefei Jiang, Chungang Zhao, Yin Zhang, Churong Li   +8 more
wiley   +1 more source