Results 151 to 160 of about 1,983,941 (246)

Activation of aryl hydrocarbon receptor (AhR) in Alzheimer's disease: role of tryptophan metabolites generated by gut host-microbiota. [PDF]

J Mol Med (Berl), 2023
Salminen A.
europepmc   +1 more source

Activation of the dioxin/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism

, 2006
International audienceEnvironmental chemicals such as dioxin adversely affect immune, neurological and reproductive functions and have been implicated in cancer development.
Koehle, C., Diry, M., Coumoul, Xavier, Barouki, R., Tomkiewicz, C., Transy, C., Bock, K. Walter   +6 more
core   +1 more source

Oolong Tea Extracts Alleviated Dextran Sulfate Solidum‐Induced Ulcerative Colitis Associated With Gut Microbiota–SCFAs–IL‐22 Axis

Food Frontiers, Volume 7, Issue 6, November 2026.
OTE attenuated the dextran sulfate sodium (DSS)–induced colitis by preserving intestinal barrier integrity, reducing oxidative stress and regulating inflammatory cytokines associated with gut microbiota–SCFAs–IL‐22 axis. ABSTRACT This study was conducted to investigate the protective effect of oolong tea extracts (OTEs) on colitis and explore its ...
Wenwen Fang, Hao Xu, Bo Tang, Liangliang Zhao, Sha Liu, Kuofei Wang, Hongzhe Zeng, Shuai Wen, Jian‐an Huang, Zhonghua Liu   +9 more
wiley   +1 more source

Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation. [PDF]

Int J Mol Sci, 2023
Nguyen PT, Nakamura Y, Tran NQV, Ishimaru K, Nguyen TA, Kobayashi Y, Watanabe-Saito F, Okuda T, Nakano N, Nakao A.   +9 more
europepmc   +1 more source

Toxicol Lett [PDF]

The objective of this study was to explore the role of the aryl hydrocarbon receptor (AhR) in ambient particulate matter (PM)-mediated activation of dendritic cells (DCs) and Th17-immune responses in vitro.

core  

Mechanistic Insights Into How Acupuncture Modulates Host Immunity via the Gut Microbiota‐Macrophage Axis

Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.
Electroacupuncture at specific acupoints (e.g., ST36, ST25) activates somato‑vagal neural circuits via PROKR2‑expressing sensory fibers. This top‑down signal restructures the gut microenvironment by enriching beneficial symbionts (e.g., Akkermansia muciniphila) and strengthening the intestinal barrier.
Tao Yang, Mei Li, Xiaowen Wu
wiley   +1 more source

Braking the system: the aryl hydrocarbon receptor controls monocytes in homeostasis

The Journal of Clinical Investigation
The aryl hydrocarbon receptor (AhR) is increasingly recognized as a physiologic modulator of the immune response, a function that extends beyond its established role as a sensor for environmental xenobiotics. In a recent report published in the JCI, Cros
Jessica E. Kenison, Francisco J. Quintana   +1 more
doaj   +1 more source

Smokeless Tobacco‐Associated Nitrosamines Impact on Aryl Hydrocarbon Receptor: In Silico and In Vitro Study

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Schematic representation of STE (smokeless tobacco extract) impact on AhR and AhR‐related genes. TSNAs present in STE induce AhR that results in to AhR conformational changes and translocation to the nucleus. Inside the nucleus, AhR heterodimerizes with Arnt and binds to XRE region of genome.
Mohammad Sajid, Ved Vrat Verma, Varun Rawat, Sonal Srivastava, Pragya Sharma, Mausumi Bharadwaj   +5 more
wiley   +1 more source

The nuclear entry of the aryl hydrocarbon receptor (AHR) relies on the first nuclear localization signal and can be negatively regulated through IMPα/β specific inhibitors. [PDF]

Sci Rep, 2023
Haidar R, Shabo R, Moeser M, Luch A, Kugler J.   +4 more
europepmc   +1 more source

Practical Considerations for the Design, Conduct, and Reporting of Clinical Pharmacokinetic Drug–Drug Interaction Studies in Drug Development

The Journal of Clinical Pharmacology, Volume 66, Issue 11, November 2026.
Abstract Clinical pharmacokinetic drug–drug interaction (PK‐DDI) studies are frequently required in drug development when metabolizing enzymes and transporters determine pharmacokinetics. Drugs can be victims, perpetrators, or victims and perpetrators, of PK‐DDIs, so the clinical consequences of these interactions, particularly the risks of severe ...
Thomas M. Polasek, John O. Miners
wiley   +1 more source