Aryl hydrocarbon receptors in osteoclast lineage cells are a negative regulator of bone mass. [PDF]
PLoS ONE, 2015 Aryl hydrocarbon receptors (AhRs) play a critical role in various pathological and physiological processes. Although recent research has identified AhRs as a key contributor to bone metabolism following studies in systemic AhR knockout (KO) or transgenic
Tai-yong Yu, Wei-jun Pang, Gong-she Yang
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AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish. [PDF]
PLoS ONE, 2012 The aryl hydrocarbon receptor (AHR) is well known for mediating the toxic effects of TCDD and has been a subject of intense research for over 30 years.
Britton C Goodale +5 more
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A Review of the Functional Roles of the Zebrafish Aryl Hydrocarbon Receptors. [PDF]
Toxicol Sci, 2020 Over the last two decades, the zebrafish (Danio rerio) has emerged as a stellar model for unraveling molecular signaling events mediated by the Aryl Hydrocarbon Receptor (AHR), an important ligand-activated receptor found in all eumetazoan animals ...
Shankar P +3 more
europepmc +2 more sources
Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases [PDF]
Biomedicines, 2022 The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is important for xenobiotic metabolism and binds to various endogenous and exogenous ligands present in the skin. AhR is known to be associated with diseases in various organs;
Han-Bi Kim +6 more
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Antioxidants for Healthy Skin: The Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor-Erythroid 2-Related Factor-2. [PDF]
Nutrients, 2017 Skin is the outermost part of the body and is, thus, inevitably exposed to UV rays and environmental pollutants. Oxidative stress by these hazardous factors accelerates skin aging and induces skin inflammation and carcinogenesis.
Furue M +7 more
europepmc +2 more sources
Role of aryl hydrocarbon receptors in infection and inflammation [PDF]
Frontiers in ImmunologyThe aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by various ligands, including pollutants, microorganisms, and metabolic substances.
Linglan Xu +7 more
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Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs). [PDF]
PLoS ONE, 2017 The aryl hydrocarbon receptor (AHR) is a basic helix-loop-helix transcription factor conserved across phyla from flies to humans. Activated by a number of endogenous ligands and environmental toxins, studies on AHR function and gene regulation have ...
Wade W Sugden +3 more
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IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation
Frontiers in Immunology, 2021 The immunoregulatory enzyme, indoleamine 2,3-dioxygenase (IDO1) and the PD-1/PD-L1 axis are potent mechanisms that impede effective anti-tumor immunity in ovarian cancer.
Adaobi Amobi-McCloud +18 more
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Emerging Roles of Aryl Hydrocarbon Receptors in the Altered Clearance of Drugs during Chronic Kidney Disease [PDF]
Toxins, 2019 Chronic kidney disease (CKD) is a major public health problem, since 300,000,000 people in the world display a glomerular filtration rate (GFR) below 60 mL/min/1.73m2. Patients with CKD have high rates of complications and comorbidities.
Tacy Santana Machado +2 more
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Estrogen receptor and aryl hydrocarbon receptor signaling pathways [PDF]
Nuclear Receptor Signaling, 2006 Estrogen receptors (ERs) and the aryl hydrocarbon receptor (AhR) are ligand activated transcription factors and members of the nuclear receptor and bHLH-PAS superfamilies, respectively. AhR is involved in xenobiotic metabolism and in mediating the toxic effects of dioxin-like compounds.
Matthews, Jason, Gustafsson, Jan-Åke
openaire +3 more sources