Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases [PDF]
Biomedicines, 2022 The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is important for xenobiotic metabolism and binds to various endogenous and exogenous ligands present in the skin. AhR is known to be associated with diseases in various organs;
Han-Bi Kim +6 more
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Role of aryl hydrocarbon receptors in infection and inflammation [PDF]
Frontiers in ImmunologyThe aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by various ligands, including pollutants, microorganisms, and metabolic substances.
Linglan Xu +7 more
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Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs). [PDF]
PLoS ONE, 2017 The aryl hydrocarbon receptor (AHR) is a basic helix-loop-helix transcription factor conserved across phyla from flies to humans. Activated by a number of endogenous ligands and environmental toxins, studies on AHR function and gene regulation have ...
Wade W Sugden +3 more
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Emerging Roles of Aryl Hydrocarbon Receptors in the Altered Clearance of Drugs during Chronic Kidney Disease [PDF]
Toxins, 2019 Chronic kidney disease (CKD) is a major public health problem, since 300,000,000 people in the world display a glomerular filtration rate (GFR) below 60 mL/min/1.73m2. Patients with CKD have high rates of complications and comorbidities.
Tacy Santana Machado +2 more
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Aryl hydrocarbon receptors in osteoclast lineage cells are a negative regulator of bone mass. [PDF]
PLoS ONE, 2015 Aryl hydrocarbon receptors (AhRs) play a critical role in various pathological and physiological processes. Although recent research has identified AhRs as a key contributor to bone metabolism following studies in systemic AhR knockout (KO) or transgenic
Tai-yong Yu, Wei-jun Pang, Gong-she Yang
doaj +2 more sources
AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish. [PDF]
PLoS ONE, 2012 The aryl hydrocarbon receptor (AHR) is well known for mediating the toxic effects of TCDD and has been a subject of intense research for over 30 years.
Britton C Goodale +5 more
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Recombinant aryl hydrocarbon receptors for bioassay of aryl hydrocarbon receptor ligands in transgenic tobacco plants [PDF]
Plant Biotechnology Journal, 2009 SummaryDioxin residues widely contaminate soil and agricultural products at low concentrations and may accumulate in organisms at the top of food chains owing to their physicochemical properties. In this study, we have developed novel, dioxin‐inducible, reporter gene expression systems regulated by recombinant aryl hydrocarbon receptors (AhRs).
Susumu, Kodama +4 more
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Endocrine Disruptors and Breast Cancer: A Comprehensive Review [PDF]
BiomedicinesBreast cancer is one of the most prevalent malignancies affecting women worldwide. Among environmental risk factors, increasing attention has been given to endocrine-disrupting chemicals (EDCs), which can interfere with hormonal signaling pathways ...
Luiza Czaczkowska +2 more
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The Pharmacological Evidences for the Involvement of AhR and GPR35 Receptors in Kynurenic Acid-Mediated Cytokine and Chemokine Secretion by THP-1-Derived Macrophages [PDF]
MoleculesKynurenic acid (KYNA), a tryptophan metabolite, possesses immunomodulatory properties, although the molecular mechanism of this action has not yet been resolved.
Katarzyna Sawa-Wejksza +2 more
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Clinical Value of Serum Mitochondria-Inhibiting Substances in Assessing Renal Hazards: A Community-Based Prospective Study in Korea [PDF]
Endocrinology and Metabolism, 2021 Background Mitochondrial dysfunction is strongly associated with several kidney diseases. However, no studies have evaluated the potential renal hazards of serum mitochondria-inhibiting substance (MIS) and aryl hydrocarbon receptor ligand (AhRL) levels ...
Hoon Sung Choi +5 more
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