Results 1 to 10 of about 39,938 (310)
Does the aryl hydrocarbon receptor regulate pluripotency? [PDF]
Current Opinion in Toxicology, 2017 Recent evidence from embryonic stem cells suggests that the aryl hydrocarbon receptor (AHR) plays a central role in the regulation of pluripotency, a short-lived property of cells in the early blastula inner cell mass (ICM). Four key observations support this conclusion.
Chia-I, Ko, Alvaro, Puga
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Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context [PDF]
, 2012 The aryl hydrocarbon receptor (AhR) mediates the induction of a variety of xenobiotic metabolism genes. Activation of the AhR occurs through binding to a group of structurally diverse compounds, most notably dioxins, which are exogenous ligands ...
BALBONI, GIANFRANCO +10 more
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Gastroenterologìa, 2015 Aryl hydrocarbon receptor (AhR) — transcription factor activated by a large number of environmental agents, and may play a role in the pathogenesis of inflammatory bowel diseases in humans and mouse models.
O.S. Zherebiatiev, O.M. Kamyshnyi
doaj +1 more source
Dopamine is an aryl hydrocarbon receptor agonist
Biochemical Journal, 2020 Tryptophan metabolites exhibit aryl hydrocarbon receptor (AhR) agonist activity and recent studies show that the phenylalanine metabolites serotonin and carbidopa, a drug used in treating Parkinson's disease, activated the AhR. In this study, we identified the neuroactive hormone dopamine as an inducer of drug-metabolizing enzymes CYP1A1, CYP1B1, and ...
Hyejin Park +8 more
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Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation
Cell Reports, 2020 Summary: Tim-1, a phosphatidylserine receptor expressed on B cells, induces interleukin 10 (IL-10) production by sensing apoptotic cells. Here we show that mice with B cell-specific Tim-1 deletion develop tissue inflammation in multiple organs including ...
Sheng Xiao +15 more
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Environmental pollutants-dependent molecular pathways and carcinogenesis [PDF]
BioDiscovery, 2019 Exposure to environmental pollutants can modulate many biological and molecular processes such as gene expression, gene repair mechanisms, hormone production and function and inflammation, resulting in adverse effects on human health including the ...
Myriam El Helou +3 more
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Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics [PDF]
, 2012 Background Animals have developed extensive mechanisms of response to xenobiotic chemical attacks. Although recent genome surveys have suggested a broad conservation of the chemical defensome across metazoans, global gene expression responses to ...
Yadetie, Fekadu +11 more
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Using nuclear receptor activity to stratify hepatocarcinogens. [PDF]
PLoS ONE, 2011 BackgroundNuclear receptors (NR) are a superfamily of ligand-activated transcription factors that control a range of cellular processes. Persistent stimulation of some NR is a non-genotoxic mechanism of rodent liver cancer with unclear relevance to ...
Imran Shah +7 more
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Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]
, 2001 It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co-repressors,
Indarto, Dono, Izawa, Masao
core
Role of dendritic cells in the induction of regulatory T cells [PDF]
, 2011 Dendritic cells (DCs) play a key role in initiating immune responses and maintaining immune tolerance. In addition to playing a role in thymic selection, DCs play an active role in tolerance under steady state conditions through several mechanisms which ...
Rahul Kushwah, Jim Hu
core +3 more sources