Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases [PDF]
Biomedicines, 2022 The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is important for xenobiotic metabolism and binds to various endogenous and exogenous ligands present in the skin. AhR is known to be associated with diseases in various organs;
Han-Bi Kim +6 more
doaj +4 more sources
Role of aryl hydrocarbon receptors in infection and inflammation [PDF]
Frontiers in ImmunologyThe aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by various ligands, including pollutants, microorganisms, and metabolic substances.
Linglan Xu +7 more
doaj +2 more sources
Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs). [PDF]
PLoS ONE, 2017 The aryl hydrocarbon receptor (AHR) is a basic helix-loop-helix transcription factor conserved across phyla from flies to humans. Activated by a number of endogenous ligands and environmental toxins, studies on AHR function and gene regulation have ...
Wade W Sugden +3 more
doaj +2 more sources
Regulation of host immune responses by Lactobacillus through aryl hydrocarbon receptors
Medicine in Microecology, 2023 The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that serves as a key environmental sensor and mechanistic regulator of both the epithelial barrier and systemic immunity. Exogenous ligands (aromatic compounds such as dioxins)
Zhipeng Huang, Liwei Xie, Liping Huang
doaj +3 more sources
Emerging Roles of Aryl Hydrocarbon Receptors in the Altered Clearance of Drugs during Chronic Kidney Disease [PDF]
Toxins, 2019 Chronic kidney disease (CKD) is a major public health problem, since 300,000,000 people in the world display a glomerular filtration rate (GFR) below 60 mL/min/1.73m2. Patients with CKD have high rates of complications and comorbidities.
Tacy Santana Machado +2 more
doaj +2 more sources
Aryl hydrocarbon receptors in osteoclast lineage cells are a negative regulator of bone mass. [PDF]
PLoS ONE, 2015 Aryl hydrocarbon receptors (AhRs) play a critical role in various pathological and physiological processes. Although recent research has identified AhRs as a key contributor to bone metabolism following studies in systemic AhR knockout (KO) or transgenic
Tai-yong Yu, Wei-jun Pang, Gong-she Yang
doaj +2 more sources
AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish. [PDF]
PLoS ONE, 2012 The aryl hydrocarbon receptor (AHR) is well known for mediating the toxic effects of TCDD and has been a subject of intense research for over 30 years.
Britton C Goodale +5 more
doaj +2 more sources
The potential of aryl hydrocarbon receptor as receptors for metabolic changes in tumors
Frontiers in OncologyCancer cells can alter their metabolism to meet energy and molecular requirements due to unfavorable environments with oxygen and nutritional deficiencies. Therefore, metabolic reprogramming is common in a tumor microenvironment (TME).
Zhiying Wang +4 more
doaj +3 more sources
Thrombin-Induced Microglia Activation Modulated through Aryl Hydrocarbon Receptors [PDF]
International Journal of Molecular Sciences, 2023 Meei-Ling Sheu +2 more
exaly +2 more sources
Endocrine Disruptors and Breast Cancer: A Comprehensive Review [PDF]
BiomedicinesBreast cancer is one of the most prevalent malignancies affecting women worldwide. Among environmental risk factors, increasing attention has been given to endocrine-disrupting chemicals (EDCs), which can interfere with hormonal signaling pathways ...
Luiza Czaczkowska +2 more
doaj +2 more sources